?A Melatonin Alternative Drug

[Lokzo]

View: https://www.youtube.com/watch?v=rG3Qlf24W4E

 

[Peeno]

Melatonin is great it shifts the balance from estrogen to progesterone. Co-administering Melatonin With an Estradiol-Progesterone Menopausal Hormone Therapy Represses Mammary Cancer Development in a Mouse Model of HER2-Positive Breast Cancer

"Since melatonin down-regulates uterine estrogen receptors (ER) and increases uterine progesterone receptor (PR) expression (54), it has the potential to augment progesterone effects while diminishing estrogen stimulation of the uterus, despite a lower progesterone dose."

I take it and it can rally lower estrogenic symptoms and increase efficacy of progesterone. It is my favourite supplement, not just for sleep but the anti estrogenic pro progesterone action.

 

[dabdabdab]

But this guy has a different opinion, he says melatonin is a stress hormone

The Melatonin Scam: Are You Sabotaging Your Sleep with This Popular Pill? - Butter Believer

Want an easy way to start a highly-profitable, $200 million-per-year health fad? Tell the insomnia industry that your “all-natural” supplement is the cure-all secret to sleep problems, and buy your own “research” to support your claims! Yep, I’m referring to the absurdity of the “melatonin...

butterbeliever.com

 

[Grapelander]

Afabazole works great.
Stimulation of sigma receptors with afobazole blocks activation of microglia and reduces toxicity caused by amyloid-β25-35
On the Mechanism of the Cardioprotective Action of σ 1 Receptor Agonist Anxiolytic Fabomotizole Hydrochloride (Afobazole)
Antidiabetic Activity of Afobazole in Wistar Rats
Sigma-1 Receptor

Afobazole increases the bioenergy potential of brain cells and has a neuroprotective effect, protecting neurons. Sedation is very weak and is felt only when the dosage is 40-50 times higher than normal.

After taking the drug is rapidly absorbed from the gastrointestinal tract. The average retention time in the body is 1.6 hours. Metabolized mainly in the liver. The drug has low toxicity.

The positive effect of the drug is expressed in the following improvements:
The disappearance of anxiety, fear, concern
Improved sleep (in the absence of daytime sleepiness)
Relieving nervous tension, psychological discomfort
Reduced vegetative disorders (dry mouth, sweating, dizziness)
Improvement memory and attention

Afobazole has the greatest effect on individuals with asthenic type of nervous system. These patients are characterized by suspiciousness, vulnerability, lack of self-confidence, emotional lability and a tendency to stress reactions.

Afobazole is used for the following indications:
Adaptation
General anxiety disorder
Insomnia
Neurasthenia
Neurocirculatory dystonia
Premenstrual stress syndrome
Withdrawal when treating nicotine addiction
Alcohol withdrawal syndrome

Also, Afobazole is often used to relieve anxiety, fear and depression associated with somatic diseases:
Asthma
Arrhythmia
Hypertension
Coronary heart disease
Oncological diseases

 

[dabdabdab]

Afabazole works great.
Stimulation of sigma receptors with afobazole blocks activation of microglia and reduces toxicity caused by amyloid-β25-35
On the Mechanism of the Cardioprotective Action of σ 1 Receptor Agonist Anxiolytic Fabomotizole Hydrochloride (Afobazole)
Antidiabetic Activity of Afobazole in Wistar Rats
Sigma-1 Receptor

Afobazole increases the bioenergy potential of brain cells and has a neuroprotective effect, protecting neurons. Sedation is very weak and is felt only when the dosage is 40-50 times higher than normal.

After taking the drug is rapidly absorbed from the gastrointestinal tract. The average retention time in the body is 1.6 hours. Metabolized mainly in the liver. The drug has low toxicity.

The positive effect of the drug is expressed in the following improvements:
The disappearance of anxiety, fear, concern
Improved sleep (in the absence of daytime sleepiness)
Relieving nervous tension, psychological discomfort
Reduced vegetative disorders (dry mouth, sweating, dizziness)
Improvement memory and attention

Afobazole has the greatest effect on individuals with asthenic type of nervous system. These patients are characterized by suspiciousness, vulnerability, lack of self-confidence, emotional lability and a tendency to stress reactions.

Afobazole is used for the following indications:
Adaptation
General anxiety disorder
Insomnia
Neurasthenia
Neurocirculatory dystonia
Premenstrual stress syndrome
Withdrawal when treating nicotine addiction
Alcohol withdrawal syndrome

Also, Afobazole is often used to relieve anxiety, fear and depression associated with somatic diseases:
Asthma
Arrhythmia
Hypertension
Coronary heart disease
Oncological diseases

Thank you do much for posting this

 

[David PS]

A weighted blanket increases pre-sleep salivary concentrations of melatonin in young, healthy adults​

Summary​

Weighted blankets have emerged as a potential non-pharmacological intervention to ease conditions such as insomnia and anxiety. Despite a lack of experimental evidence, these alleged effects are frequently attributed to a reduced activity of the endogenous stress systems and an increased release of hormones such as oxytocin and melatonin. Thus, the aim of the present in-laboratory crossover study (26 young and healthy participants, including 15 men and 11 women) was to investigate if using a weighted blanket (~12% of body weight) at bedtime resulted in higher salivary concentrations of melatonin and oxytocin compared with a light blanket (~2.4% of body weight). We also examined possible differences in salivary concentrations of the stress hormone cortisol, salivary alpha-amylase activity (as an indicative metric of sympathetic nervous system activity), subjective sleepiness, and sleep duration. When using a weighted blanket, the 1 hour increase of salivary melatonin from baseline (i.e., 22:00) to lights off (i.e., 23:00) was about 32% higher (p = 0.011). No other significant differences were found between the blanket conditions, including subjective sleepiness and total sleep duration. Our study is the first to suggest that using a weighted blanket may result in a more significant release of melatonin at bedtime. Future studies should investigate whether the stimulatory effect on melatonin secretion is observed on a nightly basis when frequently using a weighted blanket over weeks to months. It remains to be determined whether the observed increase in melatonin may be therapeutically relevant for the previously described effects of the weighted blanket on insomnia and anxiety.