- Jun 12, 2013
This leads him to a controversial conclusion: that the saturated fat in butter, cheese and meats does not contribute to the clogging of arteries — and in fact is beneficial in moderate amounts in the context of a healthy diet (lots of fruits, vegetables, whole grains and other fresh, unprocessed foods).
He cannot remember the last time he ate anything deep-fried. He has never used margarine, and instead scrambles eggs in butter every morning. He calls eggs one of nature’s most perfect foods, something he has been preaching since the 1970s, when the consumption of cholesterol-laden eggs was thought to be a one-way ticket to heart disease.
“Eggs have all of the nine amino acids you need to build cells, plus important vitamins and minerals,” he said. “It’s crazy to just eat egg whites. Not a good practice at all.”
Fred Kummerow said:Levels of oxysterols and OxLDL increase primarily as a result of three diet or lifestyle factors:
the consumption of oxysterols from commercially fried foods such as fried chicken, fish, and french fries; oxidation of cholesterol in vivo driven by consumption of excess polyunsaturated fatty acids from vegetable oils; and cigarette smoking. Along with the consumption of trans fatty acids from partially hydrogenated vegetable oil, these diet and lifestyle factors likely underlie the persistent national burden of heart disease.
For Kummerow, the increase in sphingomyelin was a prime suspect in the blocked and calcified arteries of the cardiac patients. He had already found that the arteries of the newborn human placenta contained only about 10 percent sphingomyelin and 50 percent phosphatidylcholine (FOSS-fuh-tih-dul-COH-lean), another important phospholipid component of cell membranes.
"But when we looked at the arteries of people who had had bypass operations, we found up to 40 percent sphingomyelin and about 27 percent phosphatidylcholine," Kummerow said. "It took us many more years to discover that when you added large amounts of oxysterols to the cells, then the phosphatidylcholine changed to sphingomyelin."
Further evidence supported sphingomyelin's starring role in atherosclerosis. When Kummerow and his colleagues compared the blocked and unblocked arteries of patients needing second bypass operations, they found that the arteries with blockages contained twice as much sphingomyelin as the unblocked arteries. The calcium content of the blocked arteries (6,345 parts per million) was also much higher than that of the unblocked arteries (182 ppm).
Other studies had demonstrated a link between increases in sphingomyelin and the deposit of calcium in the coronary arteries. The mechanism by which this occurred was unclear, however. Kummerow's team searched the literature and found a 1967 study that showed that in the presence of certain salts (in the blood, for example), lipids like sphingomyelin develop a negative charge. This explains the attraction of the positively charged calcium to the arterial wall when high amounts of sphingomyelin are present, Kummerow said.
"So there was a negative charge on the wall of this artery, and it attracted calcium from the blood until it calcified the whole artery," he said.
Mittir said:....It puzzles me how so called experts in
lipid did not see the danger of PUFA but people like Ray Peat and Fred Kummerow
recognized this early. RP mentioned that he took more courses in
biochemistry than biology in graduate school. Dr Kummerow has PhD
in biochemistry. Then we have Harvard lipid scholar Dr Mozaffarian M.D.
with Ph.D in epidemiology.
Mittir said:RP mentioned that he saw abundance of research showing
toxicity of PUFA while he was writing his dissertation....He talked about agricultural
studies showing lower metabolism in PUFA fed animals.
RP mentioned that Broda Barnes got his M.D. after he got his Ph.D.
aguilaroja said:Certainly, it's likely that there is more time for reflection during graduate research work than exhaustive medical duties.
Mittir said:I believe something happens to the brains of medical students.
Mittir said:RP mentioned that Broda Barnes got his M.D.
after he got his Ph.D.That is why he is different than regular M.D.
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