A Friend Has 550 Triglycerides, What Lowers It Safely?

[ecstatichamster]

Thank you for any insight.

 

[Hans]

Copper helps to lower elevated cholesterol and triglycerides.
But what's his diet like? Elevated tris can be due to excess conversion of carbs to fat or due to excess lipolysis and the liver is re-esterifying the FFAs back to trigs. So aspirin could also be helpful.
Lowering hyperinsulinemia should also help.

 

[Frankdee20]

I have 450 trigs , and 278 cholesterol.... BUMP .... Niacin May help, maybe thyroid, maybe fish oils, avoiding sugar, maybe Chromium, and maybe Bergamot

 

[ecstatichamster]

I wonder if a high carb low fat diet would lower triglycerides due to the Randall Cycle.

 

[Frankdee20]

I wonder if a high carb low fat diet would lower triglycerides due to the Randall Cycle.

Low fat has got to be better than high fat, in general

 

[ecstatichamster]

Dr. Peat wrote:
It’s usually caused by over-eating, especially starches, and general stress.

 

[cihans]

Copper helps to lower elevated cholesterol and triglycerides.
But what's his diet like? Elevated tris can be due to excess conversion of carbs to fat or due to excess lipolysis and the liver is re-esterifying the FFAs back to trigs. So aspirin could also be helpful.
Lowering hyperinsulinemia should also help.

how to lower hyperinsulinemia?

 

[PaRa]

Eating less calories
less sat fat
less total fat

is he high bodyfat?

 

[youngsinatra]

Check for fatty liver via ultrasound and look out for metabolic syndrome biomakers (low HDL, high LDL, high triglycerides, high insulin, hypertension)

Low fat, moderate protein and high carbohydrate diet with fibrous whole food carb sources like whole grains, tubers or legumes and fruits mixed with lean animal protein. (low fat dairy, chicken, lean beef)

 

[haidut]

Thank you for any insight.

Biotin is probably the most reliable and rapid option. Multiple human studies have demonstrated rapid drop in triglycerides using doses of 10mg+ daily. Considering the MS trial used 300mg daily and did not record severe side effects, taking 10mg-20mg daily for 2-3 weeks should be relatively benign.

Biotin supplementation reduces plasma triacylglycerol and VLDL in type 2 diabetic patients and in nondiabetic subjects with hypertriglyceridemia - PubMed

Biotin is a water-soluble vitamin that acts as a prosthetic group of carboxylases. Besides its role as carboxylase prosthetic group, biotin regulates gene expression and has a wide repertoire of effects on systemic processes. The vitamin regulates genes that are critical in the regulation of...

pubmed.ncbi.nlm.nih.gov

Pharmacological concentrations of biotin reduce serum triglycerides and the expression of lipogenic genes - PubMed

Besides its role as a carboxylase prosthetic group, biotin regulates gene expression and has a wide repertoire of effects on systemic processes. Several studies have shown that pharmacological concentrations of biotin reduce hypertriglyceridemia. The molecular mechanisms by which pharmacological...

pubmed.ncbi.nlm.nih.gov

The hypotriglyceridemic effect of biotin supplementation involves increased levels of cGMP and AMPK activation - PubMed

In addition to its role as a carboxylase cofactor, biotin modifies gene expression and has manifold effects on systemic processes. Several studies have shown that biotin supplementation reduces hypertriglyceridemia. We have previously reported that this effect is related to decreased expression...

pubmed.ncbi.nlm.nih.gov

Effects of biotin on lipids and other constituents of plasma of healthy men and women - PubMed

A double-blind study of the effect of biotin supplementation (0.9 mg/day) of self-selected diets on plasma lipids and other plasma constituents was carried out in 40 men and women, age 30 to 60 years, for 71 days. Comparison of percent change from control levels showed significant treatment...

pubmed.ncbi.nlm.nih.gov

Protective effect of supplementation with biotin against high-fructose-induced metabolic syndrome in rats - PubMed

Several reports have demonstrated that pharmacological concentrations of biotin reduce hyperglycemia, hypertriglyceridemia, and hypertension. We hypothesized that biotin could exert a protective effect on some illness-associated metabolic syndrome. To test this hypothesis, male Wistar rats were...

pubmed.ncbi.nlm.nih.gov

 

[ecstatichamster]

Thanks @haidut extremely helpful. I took 100mg of biotin once or twice a day for a few months with no ill effects at all.

 

[yerrag]

It's either there is a lot of lipolysis going on that increases his serum fatty acids, or that he isn't burning enough fatty acids. Either one of those, or both, could be going on.

If he is too low on insulin, there won't be enough insulin to inhibit lipolysis. As insulin inhibits lipolysis. But, since insulin also inhibits glycogenolysis, proteolysis, glucogenesis, and ketogenesis, being low on insulin would also mean he would have high blood sugar, as there is just too much supply of sugar and this leads usually to diabetes.



So, if he doesn't have diabetes, then his high free fatty acid condition would be due to low burning of fatty acids. So he may be low on carnitine.

Carnitine is synthesised in five steps that also involve the essential co-factors vitamin B6, vitamin B12, niacin and folic acid. A deficiency in any of these substances may limit carnitine biosynthesis (

https://www.aminoacid-studies.com/areas-of-use/fat-burning.html).