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A 3rd Opinion - What does this blood test mean?

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My husband had this blood test taken under stressful conditions from a spinal compression fracture, that originally happened from a golf swing. He thought it was just a pulled muscle and went about his business in pain, hoping for it to heal. When it didn't after two months he went to a highly touted back surgeon, who has 5 clinics, and he did 2 x-rays and said his back looked healthy and that there was no cancer. Five weeks later my husband drives himself to the hospital in pain to find that he had two back fractures. A blood test was sent out to Mayo Clinic and was labeled "Smouldering Myeloma" by somebody at the clinic or hospital, I don't know, but the Oncologist at the hospital says he has Myeloma. There has been so many conflicting opinions and dropping the ball with his health, with every twist and turn, this last couple of months, and so much pressure from doctors wanting his business, suggesting a bone marrow transplant, stem cell and gene therapies, before ever meeting him or doing a biopsy. He had a blood test and urine analysis done two weeks earlier at Urgent Care owned by the same hospital with elevated proteins showing up in his urine, which they diagnosed as kidney stones, which was confirmed to be true at the hospital. Can any person on this forum tell anything for certain from his blood test without further testing and a third opinion?
 

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Dolomite

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My husband had this blood test taken under stressful conditions from a spinal compression fracture, that originally happened from a golf swing. He thought it was just a pulled muscle and went about his business in pain, hoping for it to heal. When it didn't after two months he went to a highly touted back surgeon, who has 5 clinics, and he did 2 x-rays and said his back looked healthy and that there was no cancer. Five weeks later my husband drives himself to the hospital in pain to find that he had two back fractures. A blood test was sent out to Mayo Clinic and was labeled "Smouldering Myeloma" by somebody at the clinic or hospital, I don't know, but the Oncologist at the hospital says he has Myeloma. There has been so many conflicting opinions and dropping the ball with his health, with every twist and turn, this last couple of months, and so much pressure from doctors wanting his business, suggesting a bone marrow transplant, stem cell and gene therapies, before ever meeting him or doing a biopsy. He had a blood test and urine analysis done two weeks earlier at Urgent Care owned by the same hospital with elevated proteins showing up in his urine, which they diagnosed as kidney stones, which was confirmed to be true at the hospital. Can any person on this forum tell anything for certain from his blood test without further testing and a third opinion?
I am not a doctor but I used to do serum protein electrophoresis and the results you posted are suggestive of multiple myeloma. I would get a consult with the oncologist to see what options are available. I am sorry to hear he is having so many health problems. I am hoping for the best for both of you.
 

Rinse & rePeat

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I am not a doctor but I used to do serum protein electrophoresis and the results you posted are suggestive of multiple myeloma. I would get a consult with the oncologist to see what options are available. I am sorry to hear he is having so many health problems. I am hoping for the best for both of you.
Thank you Dolomite.
 

Rinse & rePeat

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Maybe something from his tetanus shot triggered the bone marrow.
We have been 100% sure that the tetanus shot set things in motion because a painful knot came up right after getting it and pain has been mounting ever since. I posted his experience on my Tetanus thread.

 

Rinse & rePeat

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Maybe something from his tetanus shot triggered the bone marrow.
This is a very good link that you have posted, with disturbing information....

"Graphene oxide is cytotoxic, genotoxic, and magneticotoxic. The image below shows the liposome capsid containing graphene oxide in the Pfizer “vaccine.” The liposome delivers the graphene oxide to specific organs, glands and tissues, namely: the ovaries and testes; bone marrow; heart; and, brain."

"Dr. Young’s paper concludes, these Covid injections “are NOT vaccines but nanotechnological drugs working as a genetic therapy … All these so-called “vaccines” are patented and therefore their actual content is kept secret even to the buyers, who, of course, are using taxpayers’ money. So, consumers (taxpayers) have no information about what they are receiving in their bodies by inoculation.”
 

Rinse & rePeat

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So I wrote to two times to Ray Peat about my husband's desperate health crisis and he answered my second e-mail from this morning. Can someone please put this into layman's terms, or blonde girl terms so I can quickly get on this?

Hello Mr. Peat!

Maybe my first e-mail to you was too long. My husband has myeloma and we are not going to do the usual cancer treatments. Do you have any recommendations as to what we can do to slow the progression, besides aspirin. Also is progesterone and pregnenolone good for his cancer?

"I didn’t get the first one, or the attached blood test results. Did they measure his TSH, vitamin D, prolactin, blood clotting rate, TNFalpha? Carbon dioxide, in the form of gas or baking soda, helps to strengthen bones, without the side effects of commonly used drugs. The drug acetazolamide which is used for altitude sickness, sleep apnea, and epilepsy, increases the amount of CO2 in the body, and favors bone integrity and reduces pain.

Blood (2017) 130 (Supplement 1): 4376.
Myeloma: Biology and Pathophysiology, excluding Therapy: Poster III| December 7, 2017
Targeting of the Hypoxia-Induced Acid Microenvironment of Multiple Myeloma Cells Increases Hypoxia-Mediated Apoptosis
Gilberto Gastelum, MS, Jeffery Kraut, MD, Aleksandra Poteshkina, BS,Edgar Artiga, MS, Geraldine Weckstein, Patrick Frost, PhD
Abstract
Multiple myeloma (MM) is an incurable disease in which malignant plasma cells engraft within the bone marrow (BM). It is postulated that components of the BM microenvironment provide pro-survival and pro-growth signals to MM cells thereby facilitating their survival and proliferation. Because the BM is known to be hypoxic, we hypothesized that low pO2 activates an adaptive response mediated by hypoxia inducible transcriptional factors (HIFs) that protect MM cells from hypoxia-mediated apoptosis. We recently showed that targeting HIF activity with a polyamide compound (HIF-PA) that targets the hypoxic response element and blocks the ability of HIF to bind to its cognate DNA sequence both inhibits HIF-mediated gene expression and makes MM cells in culture MM xenografts engrafted in the BM of NOG mice sensitive to hypoxia-mediated killing in vitro and. In other tumors, hypoxia leads to acidification of the microenvironment that is a critical factor in their survival and spread. To examine if this is also the case for MM, we exposed a panel of cell lines to severe hypoxia (down to 0.2%) for 48 hrs. This produced a marked acidification of the microenvironment (decrease in pH from ~7.4 to ~6.4) as well as increase in the expression of carbonic anhydrase IX (CA9), a HIF-dependent enzyme important to pH regulation. Moreover, while MM cells are usually resistant to hypoxia-mediated apoptosis, exposure of 8226 MM cells to a specific CA9 inhibitor (acetazolamide) or Na+/H+ transporter inhibitor (amiloride) increased hypoxia-mediated apoptosis by 3-4 fold. Tumor cells are able to sense changes in pO2 levels through the activity of the Pryol-Hydroxylase (PHD1-3) sensing pathways. In particular, PHD3 is a known tumor suppressor gene that is frequently silenced in MM cells (including 8226), and confers resistance to hypoxia by constitutively activating HIF2a. We exogenously re-expressed PHD3 in MM cells and this concomitantly downregulated HIF2a expression in an oxygen-dependent manner and sensitized these cells to hypoxia-mediated apoptosis. Apoptosis was further increased with an acid pH. In addition, HIF-PA treatment of cells cultured under hypoxic and acidic pH (6.8) conditions showed a synergistic increase in apoptosis compared to control cells which was dependent on the PHD3 expression. Re-expression of PHD3 also resulted in an increased sensitivity to both acetazolamide and amiloride, suggesting that inhibiting HIF2a expression is critical for sensitizing MM cells to a low pH. Finally, exposure of MM cells to a low pO2 and acidic pH (6.8) significantly enhanced MM migration as detected with the transwell migration assay; whereas the movement of the MM cells was almost totally inhibited (>80%) by treatment with low concentrations of acetazolamide. The results of these studies support our hypothesis that hypoxic conditions within the BM results in MM-mediated acidification of the tumor microenvironment that facilitates the survival and migration of malignant myeloma cells. Targeting the pathways that lead to acidification of the microenvironment might be a novel and effective primary or ancillary strategy for the treatment of MM.

Aust N Z J Med. 1983 Apr;13(2):163-7.
Multiple myeloma with renal failure. A case for intensive treatment
D C Harris, L S Ibels, R B Ravich, J P Isbister, J V Wells
A series of nine consecutive patients with multiple myeloma and renal failure is presented. All patients were treated with urinary alkalinisation with sodium bicarbonate and/or acetazolamide, diuresis with saline, mannitol and/or furosemide, pulse melphalan and prednisone and, where indicated, allopurinol and aluminium hydroxide. A substantial and sustained improvement in renal function has been achieved in all nine patients. Of five patients with a urea more than 25 mmol/L at presentation, the median survival to date is 64 weeks. Of these patients only one has died --not from renal failure but pneumonia, eighteen months after presentation. The others are alive and well. The results confirm the effectiveness of these measures in both improving renal function and prolonging survival, and suggest a more optimistic prognosis for patients with multiple myeloma and renal failure."-Ray Peat
 

Birdie

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He's saying to be sure certain tests are done. Then you can let him know the results.
Sounds like he will look at the tests you already sent, if you re-send them.

Then, for now, treatment suggestions to include: Baking soda & acetazolamide

He says the baking soda can be given in two ways, either use the powder (dissolved in liquid) or a gas form (not sure how). Maybe do a DuckDuckGo search for carbon dioxide treatment.

The first Abstract is showing how acetazolamide can work in MM (Multiple Myeloma).
The seconds about urinary alkalinisation with sodium bicarbonate (baking soda).
 

Rinse & rePeat

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He's saying to be sure certain tests are done. Then you can let him know the results.
Sounds like he will look at the tests you already sent, if you re-send them.

Then, for now, treatment suggestions to include: Baking soda & acetazolamide

He says the baking soda can be given in two ways, either use the powder (dissolved in liquid) or a gas form (not sure how). Maybe do a DuckDuckGo search for carbon dioxide treatment.

The first Abstract is showing how acetazolamide can work in MM (Multiple Myeloma).
The seconds about urinary alkalinisation with sodium bicarbonate (baking soda).
Thanks Birdie! Can you tell me if it best to give on an empty stomach or with food and how much for now, until clarify with him? I don't deal with doctors so I am trying to figure out where I am gonna find that acetazolamide.
 

yerrag

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He says the baking soda can be given in two ways, either use the powder (dissolved in liquid) or a gas form (not sure how).
Peat said this actually: Carbon dioxide, in the form of gas or baking soda, helps to strengthen bones... in his reply.

In the form of gas, I can think of it being done two ways, as carbogen breathing, and with a CO2 bath. I've used carbogen breathing, using a device I bought from www.carbogenetics.com 4 years ago: Carbogen Generator – Carbogenetics. I don't know if Steve still sells it, but his website is still up. I was discussing carbogen with @Blossom in another thread, and she will start a thread on it. If only carbogen is available and sold with its own tank and adapter.

I found it very helpful when I used it recently, when I was very sick with fever and was having frequent cramps unlike any I've ever had. I used it when I tested my acid base balance and found I was in a very acidic state, and since CO2 is the body's primary substance to regulate pH, its value cannot be overstated. I used this method to determine my state:


If breathing carbogen isn't possible, then taking baking soda or magnesium bicarbonate would be helpful.

Ray has favored using acetazolamide, but I've never found his rationale well-explained to convince me it's the approach I would take. No one in the forum has been able to break it down either. Someone has said that AZT keeps the carbon dioxide within the cell, so that it can maintain its acid state, in order to maintain the integrity of its structure.

In a diseased state where metabolism isn't optimal, and mitochondrial CO2 production is wanting, wouldn't carbonic anhydrase inhibitors such as AZT keep bicarbonate from being converted to CO2 and thus keep the cell from getting more CO2? After all, CA enzyme is what the body uses to convert an acid, carbonic acid, to CO2, and to bicarbonate, a base, when the body senses acidic imbalance, and vice versa as well, where bicarbonate is converted back to CO2 and to carbonic acid, when the imbalance us on the alkaline side. I really don't know. Perhaps this is a discussion that @haidut @Jam @Hans @ecstatichamster @tankasnowgod @Mauritio @LLight @ @Wilfrid would be able to explain in layman's language without having to post another hard to read study to back up Peat's thoughts. Peat doesn't elaborate on the mechanism often and this is one instance where it's about Peat saying so where Ray has been vague by way of explanation of the mechanism. Perhaps I am wrong on my idea about how the CA enzymes in our body works as well and my premise is all wrong.
 
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Kayaker

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In the form of gas, I can think of it being done two ways, as carbogen breathing, and with a CO2 bath. I've used carbogen breathing, using a device I bought from www.carbogentics.com 4 years ago: Carbogen Generator – Carbogenetics. I don't know if Steve still sells it, but his website is still up. I was discussing carbogen with @Blossom in another thread, and she will start a thread on it. If only carbogen is available and sold with its own tank and adapter.
I'd be concerned about the acidic carbon dioxide dissolving the plastic parts and inhaling them.
 

Blossom

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I was discussing carbogen with @Blossom in another thread, and she will start a thread on it.
Yes, I will devote some time to it this weekend. Sorry it’s taking so long- work is getting in the way. :(
 

yerrag

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Yes, I will devote some time to it this weekend. Sorry it’s taking so long- work is getting in the way. :(
Sorry Blossom. I only wanted to share with you that you were right in wanting to start a thread on it. It's much easier to hop on board a thread than start one. I find that I have to let it percolate for a while myself when I start one.
 

Birdie

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Thanks Birdie! Can you tell me if it best to give on an empty stomach or with food and how much for now, until clarify with him? I don't deal with doctors so I am trying to figure out where I am gonna find that acetazolamide.
I was really tired but wanted to say something before I went to sleep. So, like somebody suggested, if he can do a bath, I've put baking soda in that with aspirin tablets and epsom salts. I would put in as much baking soda as you can get to dissolve. (I mean to have the idea of really using it, like a cup or something.)

About 20 or 30 aspirins is what I use. And a cup of Magnesium sulfate (epsom salts.)

Also, I've dissolved a teaspoon of baking soda in a glass of water. And it is good in orange juice. I don't know how much would be good to take orally. Maybe Ray could suggest if you ask.

Then, bag breathing will give him carbon dioxide too. The suggestions by yerrag sounds good. And looks like @Blossom will help with ideas soon.

The acetazolamide might come from Mexico or India. Somebody here might know. I've never looked into it.

*** I don't think it matters with food or not.
 

Rinse & rePeat

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I was really tired but wanted to say something before I went to sleep. So, like somebody suggested, if he can do a bath, I've put baking soda in that with aspirin tablets and epsom salts. I would put in as much baking soda as you can get to dissolve. (I mean to have the idea of really using it, like a cup or something.)

About 20 or 30 aspirins is what I use. And a cup of Magnesium sulfate (epsom salts.)

Also, I've dissolved a teaspoon of baking soda in a glass of water. And it is good in orange juice. I don't know how much would be good to take orally. Maybe Ray could suggest if you ask.

Then, bag breathing will give him carbon dioxide too. The suggestions by yerrag sounds good. And looks like @Blossom will help with ideas soon.

The acetazolamide might come from Mexico or India. Somebody here might know. I've never looked into it.

*** I don't think it matters with food or not.
Thank you Birdie for getting in this thread to help me. He can't sit or stand without assistance, as he can't balance, because of those locked psoas muscles. I will certainly take the oj baking soda advice straight away! I just gave a half teaspoon in water last night on an empty stomach. Bag breathing is good with the baking soda? I did find a very qualified board certified physical therapist who said he would msle an exception for house call to check him put snd see what he could do. The doctor also homeopathic and focuses on pain management. Hopefully he will have access to the acetazolamide. Here are his qualifications!

MEET DR JAMES, PT, DPT, DIACH, CFMP (PHYSICAL THERAPIST, CLASSICAL HOMEOPATH, AND CERTIFIED FUNCTIONAL MEDICINE PRACTITIONER)

......has been practicing Physical Therapy since 1998. He has extensive training and experience in Manual Therapy, Exercise Therapy, and Vestibular (Balance) Rehabilitation. Dr. James is a Board-Certified Clinical Specialist in Orthopedic Physical Therapy, and he is certified in Vithoulkas Classical Homeopathy. He is also a Certified Functional Medicine Practitioner. Dr. James graduated from the College of Physiotherapy, Madras Medical College, with a Bachelors in Physiotherapy. He graduated from Loma Linda University with Masters and Doctorate degrees in Physical Therapy. He graduated from the American Medical College of Homeopathy in association with the International Academy of Classical Homeopathy. He graduated from Functional Medicine University.
 
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Pina

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It wasn't me who gave you that advice it was birdie. Sorry to hear your husband is still in such poor health. I find when using sodium bicarbonate it's good to have ph strips to check the urine ph. As you know I too had tetanus vaccine and I've not been the same since. I started using curcumin recently so I will let you know if that helps.


 

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