5α-DHP - Liquid 5α-Dihydroprogesterone For Lab/R&D

[Kitridge30]

How much are you taking and how frequently?

That's pretty interesting, thanks for posting. The HED used were not that high. For intranasal progesterone, the HED was 0.3mg/kg and for subcutaneous was 0.6mg/kg. Both routes increased dopamine to the same extend but the intranasal route did so at half the dose compared to s.c. Also, the effects for s.c. route on dopamine was delayed (i.e. it started about 90min after administration) but achieved higher sustained levels than intranasal.

Hey guys new member here. I have been following this link and have purchased some 5a dhp...i feel like it is only fair and could be beneficial for me to chime in with any results that I experience with it.. I will keep you guys informed. I took 2 drops on the skin in separate doses yesterday. One in the ealy afternoon and one before bed. It Def helps with sleep but wake up pretty groggy. I passed out yesterday afternoon while lying in bed so think I will just do a 5 mg dose this evening and avoid from taking it during the day. I will keep you posted.

 

[ecstatichamster]

Hey guys new member here. I have been following this link and have purchased some 5a dhp...i feel like it is only fair and could be beneficial for me to chime in with any results that I experience with it.. I will keep you guys informed. I took 2 drops on the skin in separate doses yesterday. One in the ealy afternoon and one before bed. It Def helps with sleep but wake up pretty groggy. I passed out yesterday afternoon while lying in bed so think I will just do a 5 mg dose this evening and avoid from taking it during the day. I will keep you posted.

Welcome. And thank you.

 

[Kitridge30]

Yeah tanking estrogen most likely- stuff is strong in terms of lowering E.

Yeah I am on T right now and also aromidex I'm going to take a higher dose 12mg topically this evening for the first time and see what happens. If I get low estrogen effects then I am going to continue with the dhp and lowers aromidex

 

[Kitridge30]

Just like androsterone - potent anti-depressant. The saturated steroids are really where it seems to be at for improving mood. Also, unlike androsterone which gave me a bit of unrestful sleep, 5α-DHP seems to be great to improve sleep. In higher doses (20mg - 30mg daily) I also noticed androgenic effects like harder muscles and leaner body. It also seems to be rather good for memory and cognition. It is not as sedative as progesterone, so it should be useful for studying but I think that effect is individual as one potent human anesthetic agent (pregnanolone) is a metabolite of 5α-DHP.
I think it can also be used for flu protection, given the posts about progesterone being protective from both lethality and infectiveness of viruses.
Is the "Man Flu" a real thing? Science says yes - Cantech Letter

All in all, quite a versatile steroid.

How would I take 5a dhp in water? Just drop some in like half a glass? If topically where is the best place to apply? Would I run it all the way in or kind of let it just sit??

 

[Lookingforhelp]

Just posting in again... Still not doing great in terms of things. I believe I have too low E2 as confirmed by labs and symptoms.

I find a good way to test if E2 is low for me is if Cialis has any effect, currently not.

I wish I could replicate the inital 5a DHP reaction I had. I think the reason it is not being as postitive as before is due to my already low E2.

This question is aimed at @haidut. Do you think that with my low E2 symptoms which have lasted over the last 3 years, I would be better off trying Progesterone? Would it help estrogen sensitivity? I am extremely lean with no body fat. I also feel no pump in my muscles which I also attribute to Low E2 as well as clicking joints.

Thanks again and loveeee this forum!

 

[haidut]

How would I take 5a dhp in water? Just drop some in like half a glass? If topically where is the best place to apply? Would I run it all the way in or kind of let it just sit??

The 5a-DHP is very lipophilic, so it does not mix well with water. Since it is dissolved in tocopherol/oil it probably just form mulsion in water and then you can drink that but it mixes best with fat. Most people rub ointments so they form a think layer on the skin and Peat said he rubs it in until it is almost dry.

 

[haidut]

Just posting in again... Still not doing great in terms of things. I believe I have too low E2 as confirmed by labs and symptoms.

I find a good way to test if E2 is low for me is if Cialis has any effect, currently not.

I wish I could replicate the inital 5a DHP reaction I had. I think the reason it is not being as postitive as before is due to my already low E2.

This question is aimed at @haidut. Do you think that with my low E2 symptoms which have lasted over the last 3 years, I would be better off trying Progesterone? Would it help estrogen sensitivity? I am extremely lean with no body fat. I also feel no pump in my muscles which I also attribute to Low E2 as well as clicking joints.

Thanks again and loveeee this forum!

Regular progesterone would also antagonize estrogen. I would do blood tests for estrogen and prolactin and then decide on what to supplement.

 

[Gaga]

@haidut, different situation, rat's serum estradiol is low but fair amount of fat in midsection,chest.
What would you recommend to use from your products that can kick rat's estrogen out of tissue without tanking serum?

 

[ddjd]

@haidut any idea why 5adhp is so good at reducing stress response from alcohol and it pretty much neutralises a hang over... Is it the anti Estrogenic effect?

 

[haidut]

@haidut any idea why 5adhp is so good at reducing stress response from alcohol and it pretty much neutralises a hang over... Is it the anti Estrogenic effect?

I suspect it is more of an anti-serotonin effect, especially in the gut. Allopregnanolone, which 5a-DHP raises, is an antagonist of 5-HT3.
Progesterone, Testosterone, Allopregnanolone Are Serotonin Antagonists

Ondansetron, another 5-HT3 antagonist, is commonly used off-label for stopping a hangover. There is a "clinic on wheels" in Vegas, staffed with doctors, which gives people electrolytes and ondansetron to stop hangovers.

 

[ddjd]

I suspect it is more of an anti-serotonin effect, especially in the gut. Allopregnanolone, which 5a-DHP raises, is an antagonist of 5-HT3.
Progesterone, Testosterone, Allopregnanolone Are Serotonin Antagonists

Ondansetron, another 5-HT3 antagonist, is commonly used off-label for stopping a hangover. There is a "clinic on wheels" in Vegas, staffed with doctors, which gives people electrolytes and ondansetron to stop hangovers.

Do not stop selling this stuff haidut. I love it

 

[haidut]

Do not stop selling this stuff haidut. I love it.

No worries, we have no intention of stopping it. FDA can ban 11-keto DHT but 5a-DHP is a progestin and should be safe (for now).

 

[Black Ops]

Just wondering how you check what substance are going to be banned by the FDA. A link would be nice :)

 

[haidut]

Just wondering how you check what substance are going to be banned by the FDA. A link would be nice :)

There is no link for that. Let's just say I have my channels

 

[ddjd]

@haidut not sure if you've already answered this but is there an upper limit to daily intake of 5adhp? Is daily too often?

Rat usually takes 5 drops orally in one dose and sometimes daily but usually 2/3 times a week. Thinking about doing daily

 

[haidut]

@haidut not sure if you've already answered this but is there an upper limit to daily intake of 5adhp? Is daily too often?

Rat usually takes 5 drops orally in one dose and sometimes daily but usually 2/3 times a week. Thinking about doing daily

The studies on breast cancer found increased risk from HED of 30mg+ daily. The studies on estrogen/prolactin inhibition showed biphasic effect and the low dose (HED of about 5mg-6mg) was about as effective as the next effective dose of ~15mg. Allopregnanolone synthesis is also probably suffuciently increased with 6mg - 8mg. So, I do not see a reason to use more than 5mg-8mg daily.

 

[ddjd]

The studies on breast cancer found increased risk from HED of 30mg+ daily. The studies on estrogen/prolactin inhibition showed biphasic effect and the low dose (HED of about 5mg-6mg) was about as effective as the next effective dose of ~15mg. Allopregnanolone synthesis is also probably suffuciently increased with 6mg - 8mg. So, I do not see a reason to use more than 5mg-8mg daily.

sorry can you clarify HED

 

[haidut]

sorry can you clarify HED

Human-equivalent dose.

 

[ddjd]

However, in people who are under stress, have neurological damage, have endured treatment with finsateride, or are simply loaded with PUFA the enzyme 5-AR is downregulated both in levels and in activity. As such, simply supplementing with progesterone may not have the desired effects of raising allopregnanolone. This may be one of the reasons why progesterone seems to lose effectiveness as an anti-depressant in older people - i.e. they have much lower expression and activity of 5-AR compared to younger people.

in this situation where progesterone doesnt convert into allopregnenolone, does it turn into estrogen?

 

[ddjd]

is this an accurate summary of the pathways

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