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5α-Dihydroprogesterone (5α-DHP) - Pro-hormone And Neurosteroid For R&D

Discussion in 'IdeaLabs' started by haidut, Nov 23, 2016.

  1. Kitridge30

    Kitridge30 Member

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    Hey guys new member here. I have been following this link and have purchased some 5a dhp...i feel like it is only fair and could be beneficial for me to chime in with any results that I experience with it.. I will keep you guys informed. I took 2 drops on the skin in separate doses yesterday. One in the ealy afternoon and one before bed. It Def helps with sleep but wake up pretty groggy. I passed out yesterday afternoon while lying in bed so think I will just do a 5 mg dose this evening and avoid from taking it during the day. I will keep you posted.
     
  2. ecstatichamster

    ecstatichamster Member

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    Welcome. And thank you.
     
  3. Kitridge30

    Kitridge30 Member

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    Yeah I am on T right now and also aromidex I'm going to take a higher dose 12mg topically this evening for the first time and see what happens. If I get low estrogen effects then I am going to continue with the dhp and lowers aromidex
     
  4. Kitridge30

    Kitridge30 Member

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    How would I take 5a dhp in water? Just drop some in like half a glass? If topically where is the best place to apply? Would I run it all the way in or kind of let it just sit??
     
  5. Lookingforhelp

    Lookingforhelp Member

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    Just posting in again... Still not doing great in terms of things. I believe I have too low E2 as confirmed by labs and symptoms.

    I find a good way to test if E2 is low for me is if Cialis has any effect, currently not.

    I wish I could replicate the inital 5a DHP reaction I had. I think the reason it is not being as postitive as before is due to my already low E2.

    This question is aimed at @haidut. Do you think that with my low E2 symptoms which have lasted over the last 3 years, I would be better off trying Progesterone? Would it help estrogen sensitivity? I am extremely lean with no body fat. I also feel no pump in my muscles which I also attribute to Low E2 as well as clicking joints.

    Thanks again and loveeee this forum!
     
  6. OP
    haidut

    haidut Member

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    The 5a-DHP is very lipophilic, so it does not mix well with water. Since it is dissolved in tocopherol/oil it probably just form mulsion in water and then you can drink that but it mixes best with fat. Most people rub ointments so they form a think layer on the skin and Peat said he rubs it in until it is almost dry.
     
  7. OP
    haidut

    haidut Member

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    Regular progesterone would also antagonize estrogen. I would do blood tests for estrogen and prolactin and then decide on what to supplement.
     
  8. Gaga

    Gaga Member

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    @haidut, different situation, rat's serum estradiol is low but fair amount of fat in midsection,chest.
    What would you recommend to use from your products that can kick rat's estrogen out of tissue without tanking serum?
     
  9. Joeyd

    Joeyd Member

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    @haidut any idea why 5adhp is so good at reducing stress response from alcohol and it pretty much neutralises a hang over... Is it the anti Estrogenic effect?
     
  10. OP
    haidut

    haidut Member

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    I suspect it is more of an anti-serotonin effect, especially in the gut. Allopregnanolone, which 5a-DHP raises, is an antagonist of 5-HT3.
    Progesterone, Testosterone, Allopregnanolone Are Serotonin Antagonists

    Ondansetron, another 5-HT3 antagonist, is commonly used off-label for stopping a hangover. There is a "clinic on wheels" in Vegas, staffed with doctors, which gives people electrolytes and ondansetron to stop hangovers.
     
  11. Joeyd

    Joeyd Member

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    Do not stop selling this stuff haidut. I love it
     
  12. OP
    haidut

    haidut Member

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    No worries, we have no intention of stopping it. FDA can ban 11-keto DHT but 5a-DHP is a progestin and should be safe (for now).
     
  13. Black Ops

    Black Ops Member

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    Just wondering how you check what substance are going to be banned by the FDA. A link would be nice :)
     
  14. OP
    haidut

    haidut Member

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    There is no link for that. Let's just say I have my channels :):
     
  15. Joeyd

    Joeyd Member

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    @haidut not sure if you've already answered this but is there an upper limit to daily intake of 5adhp? Is daily too often?

    Rat usually takes 5 drops orally in one dose and sometimes daily but usually 2/3 times a week. Thinking about doing daily
     
  16. OP
    haidut

    haidut Member

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    The studies on breast cancer found increased risk from HED of 30mg+ daily. The studies on estrogen/prolactin inhibition showed biphasic effect and the low dose (HED of about 5mg-6mg) was about as effective as the next effective dose of ~15mg. Allopregnanolone synthesis is also probably suffuciently increased with 6mg - 8mg. So, I do not see a reason to use more than 5mg-8mg daily.
     
  17. Joeyd

    Joeyd Member

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    sorry can you clarify HED
     
  18. OP
    haidut

    haidut Member

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    Human-equivalent dose.
     
  19. Joeyd

    Joeyd Member

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    in this situation where progesterone doesnt convert into allopregnenolone, does it turn into estrogen?
     
  20. Joeyd

    Joeyd Member

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