38 Male UK. Tired Of Being Like The Walking Dead

[Kingpinguin]

Noticed my prolactin is pretty high in range. Someone said that’s a good indicator of estrogen being problematic. Backs up my high shbg - high estrogen theory.

just saw your tests and was just thinking the same. Could be many several reasons for higher prolactin. I actually at one point also tested high shbg, prolactin and cortisol. But back then I did so many several combinations of things that it’s hard to remember what exactly solved it.

anyway what I see stands out the most from the test with ferritin is that all your iron parameters indicate low grade chronic inflammation.
Transferrin was low, blood iron was low, ferritin was high but your saturation normal. This indicstes that you’re body is trying to keep iron away from the blood bound up in ferritin. Its a self defence mechanism of the body to protect itself. What you want to strive for is ferritin Under 150 at least and then rather have high serum iron. That means your iron mobilization is working optimal.
From your ferritin results you might get tricked that you’re iron is high and that you are good but in fact you can likely be iron deficient caused by inflammation. Ferritin reacts to inflammation so it goes up. If you got rid of your inflammation it will likely fall to 100-200 maybe even lower. Your serum iron will go up a bit aswell as your transferrin.
On that test you did you’re body is restricting iron availablility and thats not good.
It can easily be the reason why you feel tired, fatigued and low drive.
Iron availability is extremely important in dopamine synthezis. Like you don’t know. I would call it the most important nutrient for dopamine function and energy. Also theres several studies linking iron to low dopamine and raised prolactin.
Inflammation also raises hepcidin production in the liver. High hepcidin blocks iron absorption in the intestines. Its the main regulator of iron absorption. So chronic inflammation can increase ferritin, lower serum iron and transferrin and lower iron absorption that will eventually lead to true low iron and anemia.
I would try to fix this actually.
You have to figure out whats causing you’re body to act like its inflammed.

 

[Diddleum]

just saw your tests and was just thinking the same. Could be many several reasons for higher prolactin. I actually at one point also tested high shbg, prolactin and cortisol. But back then I did so many several combinations of things that it’s hard to remember what exactly solved it.

anyway what I see stands out the most from the test with ferritin is that all your iron parameters indicate low grade chronic inflammation.
Transferrin was low, blood iron was low, ferritin was high but your saturation normal. This indicstes that you’re body is trying to keep iron away from the blood bound up in ferritin. Its a self defence mechanism of the body to protect itself. What you want to strive for is ferritin Under 150 at least and then rather have high serum iron. That means your iron mobilization is working optimal.
From your ferritin results you might get tricked that you’re iron is high and that you are good but in fact you can likely be iron deficient caused by inflammation. Ferritin reacts to inflammation so it goes up. If you got rid of your inflammation it will likely fall to 100-200 maybe even lower. Your serum iron will go up a bit aswell as your transferrin.
On that test you did you’re body is restricting iron availablility and thats not good.
It can easily be the reason why you feel tired, fatigued and low drive.
Iron availability is extremely important in dopamine synthezis. Like you don’t know. I would call it the most important nutrient for dopamine function and energy. Also theres several studies linking iron to low dopamine and raised prolactin.
Inflammation also raises hepcidin production in the liver. High hepcidin blocks iron absorption in the intestines. Its the main regulator of iron absorption. So chronic inflammation can increase ferritin, lower serum iron and transferrin and lower iron absorption that will eventually lead to true low iron and anemia.
I would try to fix this actually.
You have to figure out whats causing you’re body to act like its inflammed.

Thankyou for your interesting insights. Not sure where to start. I’m fit, healthy weight. Stress free. Tried lots of diets. Guess I could do a strict elimination diet.

 

[Diddleum]

hey Tara, replying on phone so not very good at quoting.

1) I don’t eat much really. You’d all say I don’t eat enough but whenever I do anything to push my metabolism I feel worse. For example eating lots of carbs I feel crappy, caffeine - crappy. However occasionally, eating loads of junk and upping calories makes me feel fabulous for a a day or two. I had a window a few years ago where I felt amazing eating fast food only. Generally eating more worsens my symptoms. Mostly just carbs. I feel well ok on a low carb diet but not really living.

I maintain my weight whatever I eat. I’m muscular despite no exercise. If I eat little I just sleep
More. Weight build seems to maintain.

coffee like food occasionally makes me feel great then turns quickly to hell by the 2/3rd day.

2). Eating starch makes me feel much worse than sugar. I’ve tried loads of sugar in my milk. Temps go up but I feel crap. Currently focusing on milk and meat and enough sugar. I figure if I work in liver maybe I’ll be able to push sugar. Like my metabolism has something limiting it when I eat loads.

3). Quote possible my light recreational drugs use has done some damage. Also roaccutane and ssri use 10 years ago. I’ve had same symptoms for most my adult life however.

4) breathing is nasal. I’ve done the whole butyeko thing and my worst symptoms is when my breath is short and my control pause is like 10-15. It varies and sometimes its better like 20-30 seconds. Strictly nasal.

I’ve tried lots of diets with little success. Including just meat and fruit. Never really found any success. Don’t think I’m intolerant.

It’s dark cold and winter in uk atm. Not getting much sun. I spent two months walking cycling in California last year though and felt like I was dead the whole time. Can’t correlate sunshine with feeling good.

I get these small windows of bliss and happiness very few and far between which keeps me going. I’ve never been able to work it out. Got years of journals.

have meditated - done yoga, been very very fit , counselling, cbt, hypnotherapy, etc etc

What makes you say my ferritin is high? At 218 it’s smack in middle of range?

 

[Kingpinguin]

What makes you say my ferritin is high? At 218 it’s smack in middle of range?

Middle is not always optimal.
Most people hover around 50-200. Some people do great on 50-100.
Some people feel better on 100-150.
But mostly over 150 is defo starting to get too much ferritin.
But theres more analysis to make to get the full picture.
Ferritin can either be on the high side because of being iron overloaded or because of of chronic inflammation since like i said previously its a response the body has to inflammation.
And looking at your other iron parameters I get the indication you are not iron heavy but more a case of inflammatory high ferritin actually restricting the iron you have.

have you ever tried supplementing with copper? Its very important for iron merabolism, utilization and absorption. Its also integral for the bodies antioxidant system as super oxide dismutase enzyme needs plenty of it to function properly. And low SOD can cause chronic inflammation. Its also pro dopaminergic in the brain. Many studies show that low copper has ties to parkinsonism due to causing iron dysregulation specifically in the substantia nigra. The most iron dense region of the brain also the most dopaminergic brain region aswell.

proper iron metabolism is key to health as a dysregulation resulting either in too much iron causes oxidative damage and too low iron causes equally as much oxidative damage and makes mitochondria dysfunctional. Iron in the right amount used properly by the body believe it or not actually has antioxidant properties working to restore the oxidative/antioxidative balance. This is key for mitochondria and ATP synthesis since cells cant function without oxidation. But too much oxidation is also bad.

If you have previously used zinc without ever supplementing copper before there tends to be quite often the case that you can be copper depleted. Thats really bad. I know you told me you used zinc extensivly in large and low doses. Zinc and copper has an antagonistic effect on each other. Zinc more so than copper has on zinc. Many people report fatigue and lowered libido from zinc. Its common and its usually just a case of becoming severly copper depleted.

So a suggestion I have is that you should try a copper supplement. 2-4mg per day.

magnesium you probably tried it but I would use it again. Its very important to help with transferrin which is the enzyme that escorts iron around the body to where it’s needed. Magnesium helps the transferrin to pick up iron and it also increases the amount of iron transferrin can absorb. Win win. Its also a strong anti inflammatory and is calming to the immune system and greatly reduces the toxic burden a bad iron homeostasis can have on the body.

You said you use vitamin D so wont recommend that but its also good to take for chronic inflammation, and it also lowers hepcidin which would allow for better iron absorption. It likely does this because the body feels it can handle iron more safely with the vitamin D. Vitamin D also lowers CRP which tends to be higher when ferritin is high due to inflammation.

Vitamin A in the form of retinol I’d slso recommend it. 10 000 IU daily. You need it for the body to utilize both iron and copper. Retinol activates the livers production of an enzyme caller ceruloplasmin/ferroxidase. This enzyme is heavily copper dependent. More than 90% of yours body copper is in ceruloplasmin. So zinc supplementation can cause low ceruloplasmin. Ceruloplasmins job is just as important as transferrins job. It converts oxidized iron Fe2 to Fe3. This is needed for absorption. Fe3 is also the type of iron the body uses in all cellular processes. Iron goes back and forth from Fe3 to Fe2 in the body through chemical reactions producing energy. Its like striking the match to start a fire in your mitochondria so they can start working producing energy/heat.

imo you should go buy some copper and retinol and try that daily for a month. I think you are depleted.
High dose vitamin D without vitamin A/retinol will also cause a deficiency in retinol/vitamin A
Homeostasis is key in the body. Ying yang you know. Everything is there in a balance for a reason.

 

[Diddleum]

Middle is not always optimal.
Most people hover around 50-200. Some people do great on 50-100.
Some people feel better on 100-150.
But mostly over 150 is defo starting to get too much ferritin.
But theres more analysis to make to get the full picture.
Ferritin can either be on the high side because of being iron overloaded or because of of chronic inflammation since like i said previously its a response the body has to inflammation.
And looking at your other iron parameters I get the indication you are not iron heavy but more a case of inflammatory high ferritin actually restricting the iron you have.

have you ever tried supplementing with copper? Its very important for iron merabolism, utilization and absorption. Its also integral for the bodies antioxidant system as super oxide dismutase enzyme needs plenty of it to function properly. And low SOD can cause chronic inflammation. Its also pro dopaminergic in the brain. Many studies show that low copper has ties to parkinsonism due to causing iron dysregulation specifically in the substantia nigra. The most iron dense region of the brain also the most dopaminergic brain region aswell.

proper iron metabolism is key to health as a dysregulation resulting either in too much iron causes oxidative damage and too low iron causes equally as much oxidative damage and makes mitochondria dysfunctional. Iron in the right amount used properly by the body believe it or not actually has antioxidant properties working to restore the oxidative/antioxidative balance. This is key for mitochondria and ATP synthesis since cells cant function without oxidation. But too much oxidation is also bad.

If you have previously used zinc without ever supplementing copper before there tends to be quite often the case that you can be copper depleted. Thats really bad. I know you told me you used zinc extensivly in large and low doses. Zinc and copper has an antagonistic effect on each other. Zinc more so than copper has on zinc. Many people report fatigue and lowered libido from zinc. Its common and its usually just a case of becoming severly copper depleted.

So a suggestion I have is that you should try a copper supplement. 2-4mg per day.

magnesium you probably tried it but I would use it again. Its very important to help with transferrin which is the enzyme that escorts iron around the body to where it’s needed. Magnesium helps the transferrin to pick up iron and it also increases the amount of iron transferrin can absorb. Win win. Its also a strong anti inflammatory and is calming to the immune system and greatly reduces the toxic burden a bad iron homeostasis can have on the body.

You said you use vitamin D so wont recommend that but its also good to take for chronic inflammation, and it also lowers hepcidin which would allow for better iron absorption. It likely does this because the body feels it can handle iron more safely with the vitamin D. Vitamin D also lowers CRP which tends to be higher when ferritin is high due to inflammation.

Vitamin A in the form of retinol I’d slso recommend it. 10 000 IU daily. You need it for the body to utilize both iron and copper. Retinol activates the livers production of an enzyme caller ceruloplasmin/ferroxidase. This enzyme is heavily copper dependent. More than 90% of yours body copper is in ceruloplasmin. So zinc supplementation can cause low ceruloplasmin. Ceruloplasmins job is just as important as transferrins job. It converts oxidized iron Fe2 to Fe3. This is needed for absorption. Fe3 is also the type of iron the body uses in all cellular processes. Iron goes back and forth from Fe3 to Fe2 in the body through chemical reactions producing energy. Its like striking the match to start a fire in your mitochondria so they can start working producing energy/heat.

imo you should go buy some copper and retinol and try that daily for a month. I think you are depleted.
High dose vitamin D without vitamin A/retinol will also cause a deficiency in retinol/vitamin A
Homeostasis is key in the body. Ying yang you know. Everything is there in a balance for a reason.

really appreciate your time.

nope never tried copper. I have ordered it. Thanks.

you’ve given me plenty to go on thanks

you might be interested in this thread regarding low iron and how prolactin

.Iron Deficiency Alters Serum Prolactin (high Prolactin)

 

[Diddleum]

37.4c 60bpm

slept ok, woke up at 3am to pee. Had a good erection at that point. Woke at 0730 feeling nice and relaxed.

today is a arimidex day.

 

[Kingpinguin]

37.4c 60bpm

slept ok, woke up at 3am to pee. Had a good erection at that point. Woke at 0730 feeling nice and relaxed.

today is a arimidex day.

awesome sounds like you’re making progress then!

 

[Kingpinguin]

37.4c 60bpm

slept ok, woke up at 3am to pee. Had a good erection at that point. Woke at 0730 feeling nice and relaxed.

today is a arimidex day.

how is the bromantane going. Realized something the past days. Been using it sublingually. Much better effect. Just open a cap and pour it under your tongue. It will take like 10 minutes to dissolve. Doesnt taste anything since its mostly white crystalline cellulose. But i know bromantane is crystaline and the crystals reflects the colour of the rainbow. If you pour out a capsule and look at the powder in light
You can see that there’s actually the white cellulosa powder and then a sorta slightly light brown crystals that sparkles in the light in colour. Orally I have to take 100-200mg to get good effect. 1 sublingual 50mg capsul feels like 100-200mg oral. Try it out and report back if you feel the difference. Sublingually I can feel I’m on something.

 

[Diddleum]

how is the bromantane going. Realized something the past days. Been using it sublingually. Much better effect. Just open a cap and pour it under your tongue. It will take like 10 minutes to dissolve. Doesnt taste anything since its mostly white crystalline cellulose. But i know bromantane is crystaline and the crystals reflects the colour of the rainbow. If you pour out a capsule and look at the powder in light
You can see that there’s actually the white cellulosa powder and then a sorta slightly light brown crystals that sparkles in the light in colour. Orally I have to take 100-200mg to get good effect. 1 sublingual 50mg capsul feels like 100-200mg oral. Try it out and report back if you feel the difference. Sublingually I can feel I’m on something.

had a average day yestarday. Normal crap just getting through my working day.

don’t feel good at all today, slight headache, anxious feel a bit nauseous. Could be anything but most likely the arimidex which I’ve been building up dosage. Last dose was yestarday morning, I’ll back right down on that. I am taking what some guys take on trt. Probably that which has made me slip. Temp was only 36.2c this morning also. I did try eating more sugar with my milk last night which often makes me feel ***t so could be that. I’ll back off carbs also.

took either my third or 4th 50mg capsule of bromantane this morning. Can’t say I’ve noticed anything new at all. I’ll try the sublingual approach tomorrow or later - thanks.

read plenty of positive things about copper. Not much anecdotes but some studies. Doesn’t appear be very fashionable online - unlike zinc which is everyone’s go too. Diet wise I rarely eat any copper rich foods but regularly eat zinc rich (meat). Also looking back I may of had good periods when I was eating allying nuts or drinking a lot of tap water - both have copper. There was a study about how low copper affects insulin and glucose tolerance test which I failed when I did in hospital. So looking forward to trying.

have to go and battle through my working day feeling ***t! Hope you have a good day!

 

[Kingpinguin]

had a average day yestarday. Normal crap just getting through my working day.

don’t feel good at all today, slight headache, anxious feel a bit nauseous. Could be anything but most likely the arimidex which I’ve been building up dosage. Last dose was yestarday morning, I’ll back right down on that. I am taking what some guys take on trt. Probably that which has made me slip. Temp was only 36.2c this morning also. I did try eating more sugar with my milk last night which often makes me feel ***t so could be that. I’ll back off carbs also.

took either my third or 4th 50mg capsule of bromantane this morning. Can’t say I’ve noticed anything new at all. I’ll try the sublingual approach tomorrow or later - thanks.

read plenty of positive things about copper. Not much anecdotes but some studies. Doesn’t appear be very fashionable online - unlike zinc which is everyone’s go too. Diet wise I rarely eat any copper rich foods but regularly eat zinc rich (meat). Also looking back I may of had good periods when I was eating allying nuts or drinking a lot of tap water - both have copper. There was a study about how low copper affects insulin and glucose tolerance test which I failed when I did in hospital. So looking forward to trying.

have to go and battle through my working day feeling ***t! Hope you have a good day!

yeah its a very common problem because zinc is praised on the internet misleading and making people sick, zinc toxic, copper deficient. Diet today is already very zinc heavy and copper deficient. Yeah I think if you have a mineral imbalance then using stuff like bromantane, l-dopa etc wont do anything since there’s not the underlying functioning support needed for these supplement to work its mechanism. Makes sense. It’s like trying to get more power from an engine without fuel, or not being able tp shift gears etc. Anyway yeah imo I warn against estrogen blockers. Specially aromatase inhibitors. They are very powerful and effective at lowering estrogen and their half life is so long. You still estrogen and aromatase to feel good and function properly. The estrogen scare is a bit over-exaggerated i believe. There should be a healthy balance between T and E2. Honestly I think every third day is a bit to often. You could use your low dose once a week would still be enough to have an effect on lowering estrogen or keeping it low.

 

[Diddleum]

Bad bad day yestarday. Got through my working day then just lied in bed in the dark from 3pm. Had a mild headache and felt empty and anxious. Probably arimidex, May of been that I had like 6 cup of coffee over two days - my customers kept making it. Should of stuck to water.

I’m still waiting on a copper supplement to try. But I realised I had some nuts and cocoa powder. So I had 250grams of these tasty nuts that I’d left aside since eating peat (avoiding pufa). I’ve then been dumping a couple of teaspoons of cocoa in my warm milk. Very tasty! Didn’t realise what a nutritional powerhouse cocoa is! Dense with minerals including copper.

I felt much better by the evening. Slept well and I feel back to normal this morning. So plus one for cocoa and nuts.

I will try sublingual bromantane in a moment. Will keep on eating copper rich foods.

Waking temp has recovered...

36.5c 60bpm

 

[Kingpinguin]

Bad bad day yestarday. Got through my working day then just lied in bed in the dark from 3pm. Had a mild headache and felt empty and anxious. Probably arimidex, May of been that I had like 6 cup of coffee over two days - my customers kept making it. Should of stuck to water.

I’m still waiting on a copper supplement to try. But I realised I had some nuts and cocoa powder. So I had 250grams of these tasty nuts that I’d left aside since eating peat (avoiding pufa). I’ve then been dumping a couple of teaspoons of cocoa in my warm milk. Very tasty! Didn’t realise what a nutritional powerhouse cocoa is! Dense with minerals including copper.

I felt much better by the evening. Slept well and I feel back to normal this morning. So plus one for cocoa and nuts.

I will try sublingual bromantane in a moment. Will keep on eating copper rich foods.

Waking temp has recovered...

36.5c 60bpm

haha yeah those symptoms I recognize so well from aromazin. Empty, depressed, tired, crazy headache.
Yeah keep it up
Remember to take the copper supplement with food. It tends to cause nausea after 10 minutes if you take it on empty stomach.

 

[Bart1]

@Kingpinguin very interesting what you say about iron. I have hemochromatosis; it’s “under control “ via regular blood donations; however I can’t seem to feel good whatever I try. If you see my lab tests you see that every quarter I take blood something is off, a lot of the time too much iron I guess? High saturation high serum iron. I nails always point to a zinc deficiency (white spots) , could iron push that out for me?

 

[Kingpinguin]

@Kingpinguin very interesting what you say about iron. I have hemochromatosis; it’s “under control “ via regular blood donations; however I can’t seem to feel good whatever I try. If you see my lab tests you see that every quarter I take blood something is off, a lot of the time too much iron I guess? High saturation high serum iron. I nails always point to a zinc deficiency (white spots) , could iron push that out for me?

You are diagnosed with hemochromatosis? Like they checked your genes? Since its a genetic problem it does not behave like copper, zinc and iron do for normal people. So applying the same principles for
Someone without hemochromatosis to someone with hemochromatosis is no applicable.
However your ferritin looks good. The stored iron. Seem like you have managed to donate out that excess stored iron. But yeah the other iron parameters seem to be indicating high blood iron. Which makes sense because since your hepcidin levels are low this means you are constantly absorbing too much iron. Thats what hemochromatosis is. First thing that happens once you have absorbed iron is onbviously an increase in blood levels of iron. Thats why you always have high serum iron. If you dont donate blood your body will start binding it up to ferritin to protect you from the excess iron levels in your blood. And you will eventually get both high serum iron and high ferritin. You’re approach should be different. First since you’re absorbing iron constantly throughout the day more than needed you will require more antioxidants to balance it out. I’d go for like a vitamin E supplement like 200 IU per day or like 400 every other day.
Then what I believe is that iron, zinc and copper has a ying yang relationship where to much of one thing will cause dysregulation or lower another mineral. For someone without hemochromatosis that doesnt constantly absorb too much iron. Excess zinc can be a bad thing. It can deplete iron and copper and make people iron deficient/dysregulated. For someone with hemochromatosis the excess iron tends to increase the bodies hunger for copper aswell and together they will lower/push out zinc much faster. So in your case I would experiment with zinc supplement like 15-30mg per day see if it makes any difference for you. Zinc has been shown to lower serum iron and inhibit copper and iron absorption. And thats something that you would want. So try that. Zinc and vitamin E. Vitamin A can be positive aswell. Iron likes to accumulate in liver and organs when you have hemocrhomatosis excess. And vitamin A helps to keep it out of those wrong places.
In the end its all about controlling the oxidant against the antioxdant balance in the body. For someone like you theres too much oxidation chronically. For someone without hemochromatosis. Eating to many antioxidant can actually make normal people feel worse.
On top of that try to block iron from diet. You can use coffee for that. I think gingko biloba also iron chelator, curcurmin etc. But main focus would be vitamin E, zinc and retinol. Retinol and zinc has a special relationship aswell. Usually zinc and iron is found in the same foods so you can also become zinc deficient just be following an anti iron diet lile you are probably doing. So thats why in you case zinc could be beneficial

JBC : Journal of Biological Chemistry

this study says zinc deficieny increases iron accumilation

Vitamin E is protective against iron toxicity and iron-induced hepatic vitamin E depletion in mice. - PubMed - NCBI

this study says that vitamin E lowers the chance of death to almost zero in rats injected with a lethal dose of iron.

 

[Bart1]

You are diagnosed with hemochromatosis? Like they checked your genes? Since its a genetic problem it does not behave like copper, zinc and iron do for normal people. So applying the same principles for
Someone without hemochromatosis to someone with hemochromatosis is no applicable.
However your ferritin looks good. The stored iron. Seem like you have managed to donate out that excess stored iron. But yeah the other iron parameters seem to be indicating high blood iron. Which makes sense because since your hepcidin levels are low this means you are constantly absorbing too much iron. Thats what hemochromatosis is. First thing that happens once you have absorbed iron is onbviously an increase in blood levels of iron. Thats why you always have high serum iron. If you dont donate blood your body will start binding it up to ferritin to protect you from the excess iron levels in your blood. And you will eventually get both high serum iron and high ferritin. You’re approach should be different. First since you’re absorbing iron constantly throughout the day more than needed you will require more antioxidants to balance it out. I’d go for like a vitamin E supplement like 200 IU per day or like 400 every other day.
Then what I believe is that iron, zinc and copper has a ying yang relationship where to much of one thing will cause dysregulation or lower another mineral. For someone without hemochromatosis that doesnt constantly absorb too much iron. Excess zinc can be a bad thing. It can deplete iron and copper and make people iron deficient/dysregulated. For someone with hemochromatosis the excess iron tends to increase the bodies hunger for copper aswell and together they will lower/push out zinc much faster. So in your case I would experiment with zinc supplement like 15-30mg per day see if it makes any difference for you. Zinc has been shown to lower serum iron and inhibit copper and iron absorption. And thats something that you would want. So try that. Zinc and vitamin E. Vitamin A can be positive aswell. Iron likes to accumulate in liver and organs when you have hemocrhomatosis excess. And vitamin A helps to keep it out of those wrong places.
In the end its all about controlling the oxidant against the antioxdant balance in the body. For someone like you theres too much oxidation chronically. For someone without hemochromatosis. Eating to many antioxidant can actually make normal people feel worse.
On top of that try to block iron from diet. You can use coffee for that. I think gingko biloba also iron chelator, curcurmin etc. But main focus would be vitamin E, zinc and retinol. Retinol and zinc has a special relationship aswell. Usually zinc and iron is found in the same foods so you can also become zinc deficient just be following an anti iron diet lile you are probably doing. So thats why in you case zinc could be beneficial

JBC : Journal of Biological Chemistry

this study says zinc deficieny increases iron accumilation

Vitamin E is protective against iron toxicity and iron-induced hepatic vitamin E depletion in mice. - PubMed - NCBI

this study says that vitamin E lowers the chance of death to almost zero in rats injected with a lethal dose of iron.

Wow thank you so much for this! I've always felt better with zinc/copper supplement (zinc balance jarrow formulas). Also have to focus on the fat solubles indeed, I just had a blood test for D which is low.

 

[Shin]

just saw your tests and was just thinking the same. Could be many several reasons for higher prolactin. I actually at one point also tested high shbg, prolactin and cortisol. But back then I did so many several combinations of things that it’s hard to remember what exactly solved it.

anyway what I see stands out the most from the test with ferritin is that all your iron parameters indicate low grade chronic inflammation.
Transferrin was low, blood iron was low, ferritin was high but your saturation normal. This indicstes that you’re body is trying to keep iron away from the blood bound up in ferritin. Its a self defence mechanism of the body to protect itself. What you want to strive for is ferritin Under 150 at least and then rather have high serum iron. That means your iron mobilization is working optimal.
From your ferritin results you might get tricked that you’re iron is high and that you are good but in fact you can likely be iron deficient caused by inflammation. Ferritin reacts to inflammation so it goes up. If you got rid of your inflammation it will likely fall to 100-200 maybe even lower. Your serum iron will go up a bit aswell as your transferrin.
On that test you did you’re body is restricting iron availablility and thats not good.
It can easily be the reason why you feel tired, fatigued and low drive.
Iron availability is extremely important in dopamine synthezis. Like you don’t know. I would call it the most important nutrient for dopamine function and energy. Also theres several studies linking iron to low dopamine and raised prolactin.
Inflammation also raises hepcidin production in the liver. High hepcidin blocks iron absorption in the intestines. Its the main regulator of iron absorption. So chronic inflammation can increase ferritin, lower serum iron and transferrin and lower iron absorption that will eventually lead to true low iron and anemia.
I would try to fix this actually.
You have to figure out whats causing you’re body to act like its inflammed.

What iron supplement do you recommend?
Will try Bromantane too as I got pretty much the same symptoms as the OP.

 

[Kingpinguin]

What iron supplement do you recommend?
Will try Bromantane too as I got pretty much the same symptoms as the OP.

i wont recommend any iron supplements like that. Do you have an iron deficiency? Have you done lab works?

 

[Diddleum]

What iron supplement do you recommend?
Will try Bromantane too as I got pretty much the same symptoms as the OP.

you ever been on ssri, roaccutane ?

 

[Diddleum]

Had a pretty good day, been in a good mood. Pretty much how I woke up continued all day.

been drinking warm milk with cocoa all day for copper and metals.

Hard to say what if anything is helping. But miles better than yestarday. My estrogen could be rebounding through a sweet spot? Cocoa, bromantane, memantine?

I’ll stay away from arimidex for a while and continue with the other avenues for now.

 

[Kingpinguin]

Had a pretty good day, been in a good mood. Pretty much how I woke up continued all day.

been drinking warm milk with cocoa all day for copper and metals.

Hard to say what if anything is helping. But miles better than yestarday. My estrogen could be rebounding through a sweet spot? Cocoa, bromantane, memantine?

I’ll stay away from arimidex for a while and continue with the other avenues for now.

cool curious have you done any testing on your B12 and folate levels? B12 is extremely common to be suboptimal. I think most people are suboptimal B12 levels since its hard to obtain and absorb the amounts needed. Its critical for energy and neurotransmitter levels. Think all of my close friends and family that has ever tested it has come out at the bottom of the range. B12 is also one of those tests like testosterone that has sucha huge reference range that low on the scale most certainly means = deficiency. Like testosterone for a 20, 30, 40 even 50 year old to have even close bottom range is just a disaster how they can accept that as normal.