38 Male UK. Tired Of Being Like The Walking Dead

[Diddleum]

yeah some people might be hyperresponders to bromantane. I didnt feel anything at first also read some do feel straight away. But most sources says it has to build up. Makes sense since its not a direct dopamine releasing agent. Thats why its not addictive. Take some time for it to act on the tyrosine hydroxylase gene which needs to be activated to upregulate the enzyme synthesis. Like the overall effect is not crazy dramatic but it does make a quite noticeable difference in me after awhile. I also come from a background off quite heavy drug use which I think screwed my dopamine system a bit. Looking for anything that can long term upregulate, regenerate and boost the dopamine system. So far so good. Been using Bromantane for 1,5 month now. Hope the effects stick around after discontinuation. But thats at least what most human trials have promised. Have some other upcoming trials with nootropics ill be experimenting with. Like 9-me-bc, uridine, citicoline, modafinil and gonna try tianeptine aswell. Already used uridine and citicoline previously. Did like their effect but also very subtle nurturing the brain sort of thing. Modafinil I will not use for any reason than just getting more stuff done. Not like everyday use. Only when I feel like Ok I got lots of work to do. And tianeptine just seems like fun if used responisbly since its sort of an opioid. Use it with care I hear good reports. Some people claim it to be the devil im terms of withdrawals but thats only when you abuse it. Think normal dose is like 15mg. People complain about withdrawals after using 2 grams daily for long time. I mean common... people so dumb
haha funny how i keep playing with drugs to tru to fix drug abuse damage...
I guess once a drugy always a drugy

how do you feel phenibut. One of the only nootropics I ever felt. Beautiful at times for me.

memantine is also said to be a tyrosine hydrox’ modulator. But mostly written as a nmda antagonist.

 

[Kingpinguin]

how do you feel phenibut. One of the only nootropics I ever felt. Beautiful at times for me.

memantine is also said to be a tyrosine hydrox’ modulator. But mostly written as a nmda antagonist.

Yeah ive seen that regarding memantine. Never tried memantine myself. I have used haiduts diamant. Adamantane. I couldnt tolerate it. Gave me some weird mental state dysphoria. Feelt a bit like a strange nmda sorta keta feeling. I was because of this skeptical to bromantane but read so many great reports in it that I was curious to try. To me they are not similair at all. So my assumption is that their pharmacology do vary quite a lot. Its like I usually say. Just coz the based on the diamonoid doesnt mean a compound acts the same as each other. Look at all the phenetylamines like meth, mdma, mescaline. Structurally they very similair. Their effects are very different same goes for some of the indoles. But to a lesser extent they mostly produce hallucinations througj 5-ht2a. Anyway yeah I’ve tried phenibut. Nice high for sure calming but still a bit energetic and euphoric. Love GABA agonists in general. Used to abuse benzos a bit. But lower doses are better imo. Too high doses of GABA agonist i just get depressed and a bit tired. Same with alcohol. Best time with alcohol is the first 3 drinks. Then its just plateus and you are chasing the dragon only to become more and more drunk baboon

 

[Diddleum]

Yeah ive seen that regarding memantine. Never tried memantine myself. I have used haiduts diamant. Adamantane. I couldnt tolerate it. Gave me some weird mental state dysphoria. Feelt a bit like a strange nmda sorta keta feeling. I was because of this skeptical to bromantane but read so many great reports in it that I was curious to try. To me they are not similair at all. So my assumption is that their pharmacology do vary quite a lot. Its like I usually say. Just coz the based on the diamonoid doesnt mean a compound acts the same as each other. Look at all the phenetylamines like meth, mdma, mescaline. Structurally they very similair. Their effects are very different same goes for some of the indoles. But to a lesser extent they mostly produce hallucinations througj 5-ht2a. Anyway yeah I’ve tried phenibut. Nice high for sure calming but still a bit energetic and euphoric. Love GABA agonists in general. Used to abuse benzos a bit. But lower doses are better imo. Too high doses of GABA agonist i just get depressed and a bit tired. Same with alcohol. Best time with alcohol is the first 3 drinks. Then its just plateus and you are chasing the dragon only to become more and more drunk baboon

When I first tried Mucuana (assuming the l-dopa was the active ingredient). I felt fantastic - strong dopamine effect. Erections all day long, felt alpha. It lasted almost two days. It never had any effect after that. I assumed my receptors got numb after that.

been chasing that ever since!

I assume the dopamine receptors theory, that I’m not sensitive to the normal amounts of dopamine released by day to day pleasures. Sex, socialising, winning, money etc.

I struggle to see how up regulating TH to create more endogenous dopamine will make me feel any different if I’m sensitive to it.

I hope I’m wrong. I hope bromantane works

 

[Kingpinguin]

When I first tried Mucuana (assuming the l-dopa was the active ingredient). I felt fantastic - strong dopamine effect. Erections all day long, felt alpha. It lasted almost two days. It never had any effect after that. I assumed my receptors got numb after that.

been chasing that ever since!

I assume the dopamine receptors theory, that I’m not sensitive to the normal amounts of dopamine released by day to day pleasures. Sex, socialising, winning, money etc.

I struggle to see how up regulating TH to create more endogenous dopamine will make me feel any different if I’m sensitive to it.

I hope I’m wrong. I hope bromantane works

well if it did work that way many people would not claim bromantane have continued good effect that even last after you stop. We know it works by tyrosine hydroxylase but who knows if it doesnt sensitize dopa receptors and upregulate dopaminergic neuron differentiation. I believe it might do that. 9-me-bc actually does that but it has not been studied so extensivly so safety is kinda like meh with that one.

 

[Kingpinguin]

When I first tried Mucuana (assuming the l-dopa was the active ingredient). I felt fantastic - strong dopamine effect. Erections all day long, felt alpha. It lasted almost two days. It never had any effect after that. I assumed my receptors got numb after that.

been chasing that ever since!

I assume the dopamine receptors theory, that I’m not sensitive to the normal amounts of dopamine released by day to day pleasures. Sex, socialising, winning, money etc.

I struggle to see how up regulating TH to create more endogenous dopamine will make me feel any different if I’m sensitive to it.

I hope I’m wrong. I hope bromantane works

Btw do you watch porn at all and masturbate regularly? Even with good dopamine you can easily screw your sex drive if thats the case. Dopamine receptors in the mesolimbic system responsible for sexual response get desenstized by its owm so even with lots of available dopamine your sex drive wont improve too much.
Its a cliche but I’ve noticed it really is like that. I can tell even if I have all the symptoms of high dopamine like energy, motivation, no fatigue, perfect sleep and wake up same time every morning feeling fresh. Even in that case if I watch porn not even often it still blocks my sex drive mentally. Like it doesnt **** with my sex drive when im with a girl. But I know those times when you can get turned on just by thoughts are blocked by porn. If you want that back and also have a much higher libido the only way for me has to be abstain from pornography. Having good testosterone levels and high dopamine certainly helps but if you’re watching lots of porn even then it wont matter too much in terms of the horny mind. You’re brain will be saturated if you feed it too often with porn. I can attest that it makes a big difference abstaining as I’ve done this even in times when I’ve had Testosterone levels above the upper range of the lab test and had all symptoms of high dopamine. Porn can still kill your libido ALOT. Usually takes me 5-7 days of complete abstaining then I sorta get a rebound libido like just smelling a woman gets me wood at that point. At that point its usually really hard to abstain hahaha

just wanted to point that out that you have to acknowledge those things matter. But yeah in your case seeing your labs etc theres many things to work on and improve first

 

[Diddleum]

Btw do you watch porn at all and masturbate regularly? Even with good dopamine you can easily screw your sex drive if thats the case. Dopamine receptors in the mesolimbic system responsible for sexual response get desenstized by its owm so even with lots of available dopamine your sex drive wont improve too much.
Its a cliche but I’ve noticed it really is like that. I can tell even if I have all the symptoms of high dopamine like energy, motivation, no fatigue, perfect sleep and wake up same time every morning feeling fresh. Even in that case if I watch porn not even often it still blocks my sex drive mentally. Like it doesnt **** with my sex drive when im with a girl. But I know those times when you can get turned on just by thoughts are blocked by porn. If you want that back and also have a much higher libido the only way for me has to be abstain from pornography. Having good testosterone levels and high dopamine certainly helps but if you’re watching lots of porn even then it wont matter too much in terms of the horny mind. You’re brain will be saturated if you feed it too often with porn. I can attest that it makes a big difference abstaining as I’ve done this even in times when I’ve had Testosterone levels above the upper range of the lab test and had all symptoms of high dopamine. Porn can still kill your libido ALOT. Usually takes me 5-7 days of complete abstaining then I sorta get a rebound libido like just smelling a woman gets me wood at that point. At that point its usually really hard to abstain hahaha

just wanted to point that out that you have to acknowledge those things matter. But yeah in your case seeing your labs etc theres many things to work on and improve first

I appreciate your input.

Have never watched porn in my life. Don’t really masturbate any more. Just have sex with my gf once a week. Usually need Viagra and not in the mood and perform rubbish.

orgasm makes my symptoms worse for a few days most of the time.

zero libido generally. I done nofap with no orgasm for 100 days. At points in when I was younger nofap would make me feel great. Now I feel crap and zero interest even with abstaining. Sucks.

 

[Kingpinguin]

I appreciate your input.

Have never watched porn in my life. Don’t really masturbate any more. Just have sex with my gf once a week. Usually need Viagra and not in the mood and perform rubbish.

orgasm makes my symptoms worse for a few days most of the time.

zero libido generally. I done nofap with no orgasm for 100 days. At points in when I was younger nofap would make me feel great. Now I feel crap and zero interest even with abstaining. Sucks.

understand. Sorry to hear that. Curious have you supplemented with zinc in the past? If so what dosage did you use and how long was this usage?

 

[Diddleum]

understand. Sorry to hear that. Curious have you supplemented with zinc in the past? If so what dosage did you use and how long was this usage?

I tried zinc at all levels. Nothing. Don’t think I did it long term though.

I found this interesting..

Effects of glutamate antagonists on the activity of aromatic L-amino acid decarboxylase. - PubMed - NCBI

Your clearly better educated than me but
aromatic L-amino acid decarboxylase is what needed to make l-dopa into dopamine. This study shows these drugs notably memantine mentioned in upping activity of this.

in my awful anecdotal example of me not responding to mucuana as well any more. Maybe I just ran out of
aromatic L-amino acid decarboxylase? It’s obviously a rate limiting step in dopamine production. Gives me a little more hope!

 

[Kingpinguin]

I tried zinc at all levels. Nothing. Don’t think I did it long term though.

I found this interesting..

Effects of glutamate antagonists on the activity of aromatic L-amino acid decarboxylase. - PubMed - NCBI

Your clearly better educated than me but
aromatic L-amino acid decarboxylase is what needed to make l-dopa into dopamine. This study shows these drugs notably memantine mentioned in upping activity of this.

in my awful anecdotal example of me not responding to mucuana as well any more. Maybe I just ran out of
aromatic L-amino acid decarboxylase? It’s obviously a rate limiting step in dopamine production. Gives me a little more hope!

yes looks good.
Have you done any blood tests? Sorry if you already posted them. If so did they ever test your iron stores and levels? Ferritin, iron, transferrin? And if you have em I be interested to know what they where.

 

[Kingpinguin]

I tried zinc at all levels. Nothing. Don’t think I did it long term though.

I found this interesting..

Effects of glutamate antagonists on the activity of aromatic L-amino acid decarboxylase. - PubMed - NCBI

Your clearly better educated than me but
aromatic L-amino acid decarboxylase is what needed to make l-dopa into dopamine. This study shows these drugs notably memantine mentioned in upping activity of this.

in my awful anecdotal example of me not responding to mucuana as well any more. Maybe I just ran out of
aromatic L-amino acid decarboxylase? It’s obviously a rate limiting step in dopamine production. Gives me a little more hope!

bromantane instead acts via indirect genomic mechanisms to produce a rapid, pronounced, and long-lasting upregulation in a variety of brain regions of the expression of tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AAAD) (also known as DOPA decarboxylase),


Bromantane does the same.

 

[Diddleum]

Woke up with a nice pleasant feeling, slept well but woke twice to urinate a pathetic amount. No nighttime erections noticed.

36.4C 60 BPM.

had a real high calorie meal of fatty beef, sweet potato butter. Didn’t seem to warm me up as much as milk and sugar despite a much higher calorie/protein intake.

 

[tara]

thyroid function seems good. Bloods are fine 1.5tsh.

How much food (cals) do you eat/maintain on? What are you eating?
Consider logging all your food for a few days so you can see roughly what you are getting for nutrition on average? If you use cronometer, you can post here if you want.

I eat a portion of minced beef/salt and a apple and quickly I am now up to 36.8c.

Protein-heavy/lowish carb breakfast - have you tried increasing carb ratio?

Does the body need protein to deal with estrogen?

I think so. The liver is involved in estrogen elimination, and the liver needs protein.

Phenibut at start was amazing I felt so good, but very hit and miss now and tolerance is there after one dose.

That and maybe some of the otehr drugs you've tried might have left behind some effects?

been eating peat mostly protein without pushing metabolism.

Eating peatish means what to you?

Are you getting regular sunlight on your skin?

How's your resting breathing? Relaxed, nasal, diaphragmatic (including sleep)?

Have you considered or experimented to see if there are specific foods you are intolerant of?

 

[ThinPicking]

Hi Diddleum,

Can you tell us about your average fluid consumption in a day? Amount per serving, number of servings, the times you're consuming the fluid and the type of fluid you're consuming?

I hope to go somewhere with this.

 

[LLight]

orgasm makes my symptoms worse for a few days most of the time.

If you do not already know that: Postorgasmic illness syndrome - Wikipedia

 

[Kingpinguin]

yes looks good.
Have you done any blood tests? Sorry if you already posted them. If so did they ever test your iron stores and levels? Ferritin, iron, transferrin? And if you have em I be interested to know what they where.

@Diddleum

 

[Diddleum]

@Diddleum

uploaded some blood tests. Some when I was on testosterone - see if you can guess which!

the results pdf attachment has most comprehensive bloods when I wasn’t supplementing.

 

[Diddleum]

If you do not already know that: Postorgasmic illness syndrome - Wikipedia

yes I’ve visited that a few time over the years - thanks. Feels like I get pois. They don’t have any cure to try.

 

[Diddleum]

Hi Diddleum,

Can you tell us about your average fluid consumption in a day? Amount per serving, number of servings, the times you're consuming the fluid and the type of fluid you're consuming?

I hope to go somewhere with this.

My usual diet doesn’t have much fluid. I tend to feel better when I eat little.

my current diet for a couple of weeks now is high protein diet focusing on skim milk. So drinking 2/3 litres milk and a little orange juice.

 

[Diddleum]

How much food (cals) do you eat/maintain on? What are you eating?
Consider logging all your food for a few days so you can see roughly what you are getting for nutrition on average? If you use cronometer, you can post here if you want.

Protein-heavy/lowish carb breakfast - have you tried increasing carb ratio?


I think so. The liver is involved in estrogen elimination, and the liver needs protein.

That and maybe some of the otehr drugs you've tried might have left behind some effects?


Eating peatish means what to you?

Are you getting regular sunlight on your skin?

How's your resting breathing? Relaxed, nasal, diaphragmatic (including sleep)?

Have you considered or experimented to see if there are specific foods you are intolerant of?

hey Tara, replying on phone so not very good at quoting.

1) I don’t eat much really. You’d all say I don’t eat enough but whenever I do anything to push my metabolism I feel worse. For example eating lots of carbs I feel crappy, caffeine - crappy. However occasionally, eating loads of junk and upping calories makes me feel fabulous for a a day or two. I had a window a few years ago where I felt amazing eating fast food only. Generally eating more worsens my symptoms. Mostly just carbs. I feel well ok on a low carb diet but not really living.

I maintain my weight whatever I eat. I’m muscular despite no exercise. If I eat little I just sleep
More. Weight build seems to maintain.

coffee like food occasionally makes me feel great then turns quickly to hell by the 2/3rd day.

2). Eating starch makes me feel much worse than sugar. I’ve tried loads of sugar in my milk. Temps go up but I feel crap. Currently focusing on milk and meat and enough sugar. I figure if I work in liver maybe I’ll be able to push sugar. Like my metabolism has something limiting it when I eat loads.

3). Quote possible my light recreational drugs use has done some damage. Also roaccutane and ssri use 10 years ago. I’ve had same symptoms for most my adult life however.

4) breathing is nasal. I’ve done the whole butyeko thing and my worst symptoms is when my breath is short and my control pause is like 10-15. It varies and sometimes its better like 20-30 seconds. Strictly nasal.

I’ve tried lots of diets with little success. Including just meat and fruit. Never really found any success. Don’t think I’m intolerant.

It’s dark cold and winter in uk atm. Not getting much sun. I spent two months walking cycling in California last year though and felt like I was dead the whole time. Can’t correlate sunshine with feeling good.

I get these small windows of bliss and happiness very few and far between which keeps me going. I’ve never been able to work it out. Got years of journals.

have meditated - done yoga, been very very fit , counselling, cbt, hypnotherapy, etc etc

 

[Diddleum]

Noticed my prolactin is pretty high in range. Someone said that’s a good indicator of estrogen being problematic. Backs up my high shbg - high estrogen theory.