31575 Females Say Ray Peat Right Again

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Earlier menopause linked to everyday chemical exposures
http://news.wustl.edu/news/Pages/menopa ... icals.aspx

Persistent Organic Pollutants and Early Menopause in U.S. Women
http://journals.plos.org/plosone/articl ... ne.0116057

Women with high levels of β-hexachlorocyclohexane, mirex, p,p’-DDE, 1,2,3,4,6,7,8-heptachlorodibenzofuran, mono-(2-ethyl-5-hydroxyhexyl) and mono-(2-ethyl-5-oxohexyl) phthalate, polychlorinated biphenyl congeners −70, −99, −105, −118, −138, −153, −156, −170, and −183 had mean ages of menopause 1.9 to 3.8 years earlier than women with lower levels of these chemicals. EDC-exposed women were up to 6 times more likely to be menopausal than non-exposed women.



Ray Peat said:
August Weismann's doctrine of "mortal soma, immortal germ line," led people to postulate that "primordial germ" cells migrated into the ovary (consisting of "somatic" cells) during embryonic development, and that the baby was born with a supply of germ cells that was used up during the reproductive lifetime, accounting for the decline of fertility with aging. The fact that menstrual cycles ended around the time that fertility ended was explained by the idea that ovulation caused the release of estrogen, and that the absence of eggs caused a failure to produce estrogen, and that the absence of estrogen led to the failure of the cyclical uterine changes. It was all deduced from a mistaken ideology about the nature of life.

Several laboratories, from the 1950s through the 1980s, investigated the causes of age-related infertility. A.L. Soderwall, among others, demonstrated that an excess of estrogen makes it impossible for the uterus to maintain a pregnancy.
Subsequently, his lab showed that neither changes in the eggs nor changes in the uterus could explain age related infertility. Altered pituitary hormone cycles, resulting from changes in the brain, could account for the major changes in the ovaries and uterus.
Other experimenters, including P.M. Wise, V.M. Sopelak and R.L. Butcher (1982), P. Ascheim (1983), and D.C. Desjardins (1995) have clarified the interactions between the ovaries and the brain. For example, when the ovaries of an old animal are transplanted into a young animal, they are able to function in response to the new environment, but when the ovaries of a young animal are transplanted into an old animal, they fail to cycle. However, if the ovaries are removed from an animal when it's young, so that it lives to the normal age of infertility without being regularly exposed to surges of estrogen, it will then be able to support normal cycles when young ovaries are transplanted into it. But if it received estrogen supplements throughout its life, transplanted young ovaries will fail to cycle.

Menopause is a major landmark of aging, and if its meaning is radically misunderstood, a coherent understanding of aging is unlikely, and without an understanding of the loss of functions with age, we won't really understand life. More specifically, the real causes of the many serious problems occurring in association with the menopause will be ignored. Finding the causes of the seemingly trivial hot flash will affect the way we understand aging and its diseases.
 
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