@RisingSun just curious do you have these values:
serum uric acid
random urine uric acid
Mine are:
serum uric acid - 381; reference values are 131-458 umol/dL, which may look good, but optimal values per Dicken Weatherby are 208-351 (male) and 178-327 (female);
random urine uric acid - 18.16 mg/dL; reference values are 44-109.50; no optimal values available (Weatherby's urine analysis book ordered and on the way)
It's just a guess but I think that due to low excretion of uric acid through urine (which explains my high serum uric acid; above optimal levels), the uric acid is being excreted through the skin and the scalp. This may be affecting hair growth. I read in another thread that lactic acid activates stem cells of hair follicles; could uric acid be antagonizing these same stem cells?
I thought of this as I was looking into why my serum uric levels are high in relation to my high blood pressure. It has to do with having hypoxia in my kidneys, which would end up with lactic acid being produced as a result of using the anaerobic glycolytic pathway for energy. The lactic acid is said to antagonize renal uric acid excretion. I think both of them together causes uric acid to turn into a uric acid metabolite. This makes for crystallization, which makes the kidneys unable to excrete uric acid, and for lactic acid to be made unavailable for stem cell activation of hair follicles.
This uric acid angle also ties in with your observation of people in HK growing old becoming arthritic. The high intake of purine-rich foods leads to high uric acid levels. Living long lives because of the protection given by uric acid, but also suffering from arthritic conditions brought about by high uric acid crystallizing from an increasing acidic body.
p.s. It may very well be that as we get more Peaty, we would get to eat more foods that increase our serum uric acid - from fructose in fruits and from high-purine foods as in internal organs. That is all fine if our kidneys are able to excrete uric acid well. But how many people test their urinary uric acid levels? It's a low-cost test. It only cost me P395, or about $8.
If we know this, we can for a time work on improving our kidneys so it can return to excreting uric acid in normal, larger amounts. Succeeding in that, we can go back to such Peaty foods.
I completely agree with the uric acid / lactic acid conclusion, but not with the kidney diagnosis. My kidney function always reads good and doesn’t « feel off ».
I am more inclined to think of a liver issue that would cause high lactic acid, which correlates to my liver sending accute pinching pains several times a day.
I will try the liver flush next week and report