RP: I think so. Sugar, niacinamide and aspirin are all things that'll help to lower the stress and keep the immune system up.
Caller: 15 aspirins per day?
RP: Around that.
http://www.raypeatforum.com/forum/viewtopic.php?f=73&t=6093
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RP: I think so. Sugar, niacinamide and aspirin are all things that'll help to lower the stress and keep the immune system up.
Caller: 15 aspirins per day?
RP: Around that.
RPDiciple said:but that is baby aspirins i guess wich is 80 mg ? so thats only 1 gram or around that a day. Not much
RPDiciple said:but that is baby aspirins i guess wich is 80 mg ? so thats only 1 gram or around that a day. Not much
haidut said:RPDiciple said:but that is baby aspirins i guess wich is 80 mg ? so thats only 1 gram or around that a day. Not much
I think he meant the regular 325mg tablets. High doses of aspirin are sometimes used in clinical practice. There is a human study that used 90mg/kg (5g-7g daily for a human) resulting in complete restoration of insulin sensitivity without any weight loss - i.e. people stayed fat but were no longer diabetic (type II). If suppression of fatty acids is what restored the insulin sensitivity and is also implicated in HIV pathology like Ray suggested, then 15 tablets of 325mg each is probably about right.
Just my 2c.
RPDiciple said:Interesting.
But i thought aspirin was also good to use for weight/fat loss?
schultz said:haidut said:RPDiciple said:but that is baby aspirins i guess wich is 80 mg ? so thats only 1 gram or around that a day. Not much
I think he meant the regular 325mg tablets. High doses of aspirin are sometimes used in clinical practice. There is a human study that used 90mg/kg (5g-7g daily for a human) resulting in complete restoration of insulin sensitivity without any weight loss - i.e. people stayed fat but were no longer diabetic (type II). If suppression of fatty acids is what restored the insulin sensitivity and is also implicated in HIV pathology like Ray suggested, then 15 tablets of 325mg each is probably about right.
Just my 2c.
Amazing! Do you happen to have a link to this study? I would love to give it a read.
haidut said:schultz said:haidut said:RPDiciple said:but that is baby aspirins i guess wich is 80 mg ? so thats only 1 gram or around that a day. Not much
I think he meant the regular 325mg tablets. High doses of aspirin are sometimes used in clinical practice. There is a human study that used 90mg/kg (5g-7g daily for a human) resulting in complete restoration of insulin sensitivity without any weight loss - i.e. people stayed fat but were no longer diabetic (type II). If suppression of fatty acids is what restored the insulin sensitivity and is also implicated in HIV pathology like Ray suggested, then 15 tablets of 325mg each is probably about right.
Just my 2c.
Amazing! Do you happen to have a link to this study? I would love to give it a read.
Yep, here it is. As you can see the results from 7g a day were impressive in terms of metabolic health biomarkers, even though the patients stayed fat. So much for needing to lose weight being the only way to get healthy.
http://www.ncbi.nlm.nih.gov/pubmed/12021247/
"...To test this hypothesis, we studied nine type 2 diabetic subjects before and after 2 weeks of treatment with aspirin ( approximately 7 g/d). Subjects underwent mixed-meal tolerance tests and hyperinsulinemic-euglycemic clamps with [6,6-(2)H2]glucose to assess glucose turnover before and after treatment. High-dose aspirin treatment resulted in a approximately 25% reduction in fasting plasma glucose, associated with a approximately 15% reduction in total cholesterol and C-reactive protein, a approximately 50% reduction in triglycerides, and a approximately 30% reduction in insulin clearance, despite no change in body weight. During a mixed-meal tolerance test, the areas under the curve for plasma glucose and fatty acid levels decreased by approximately 20% and approximately 50%, respectively. Aspirin treatment also resulted in a approximately 20% reduction in basal rates of hepatic glucose production and a approximately 20% improvement in insulin-stimulated peripheral glucose uptake under matched plasma insulin concentrations during the clamp. In conclusion, these data support the hypothesis that IKKbeta represents a new target for treating type 2 diabetes mellitus."
narouz said:RP: I think so. Sugar, niacinamide and aspirin are all things that'll help to lower the stress and keep the immune system up.
Caller: 15 aspirins per day?
RP: Around that.
http://www.raypeatforum.com/forum/viewtopic.php?f=73&t=6093
oxidation_is_normal said:I would not recommend much aspirin for HIV patients. It is very hard on the liver, and generally - without knowing the specific case - HIV patients have a lot of liver damage from previous drug use and/or the antiretrovirals they were prescribed.
burtlancast said:Ray mentioned a trial during the eighties where they used high dose aspirin for AIDS: it was so successful, they chose to stop it as to not concurrence the new anti retrovirals.
I never could find these studies.
The transcription factor nuclear factor-kappa B (NF-kappa B) is critical for the inducible expression of multiple cellular and viral genes involved in inflammation and infection including interleukin-1 (IL-1), IL-6, and adhesion molecules. The anti-inflammatory drugs sodium salicylate and aspirin inhibited the activation of NF-kappa B, which further explains the mechanism of action of these drugs. This inhibition prevented the degradation of the NF-kappa B inhibitor, I kappa B, and therefore NF-kappa B was retained in the cytosol. Sodium salicylate and aspirin also inhibited NF-kappa B-dependent transcription from the Ig kappa enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells.
haidut said:I found those studies Ray is talking about on PubMed but I can't find their actual text. They were published in Nature, so if someone can find the full text it would be really helpful.
"CRIA decided to halt its ongoing study of the anti-HIV effects of aspirin, at the recommendation of our Data Safety Monitoring Board (DSMB) and the study's Principal Investigator Dr. Donald Kotler. Preliminary evidence of virus reduction, however, was sufficiently promising that CRIA is now investigating a related chemical, called Trilisate, that may be less toxic. The decision to stop the aspirin study was based on evidence of slight reductions in hematocrit, a measure of the number of red blood cells, among patients taking high-dose aspirin, as well as modest increases in liver enzymes. Due to our concern about these toxicities, which are common with regular use of highdose aspirin, we had built additional safety reviews into the study from the start. Patients experiencing adverse events were taken off treatment as a precaution, and all laboratory values returned to normal following treatment."
burtlancast said:Here's what the University of Maryland has to say:
Some studies show willow is as effective as aspirin for reducing pain and inflammation (but not fever), and at a much lower dose.
White willow appears to bring pain relief more slowly than aspirin, but its effects may last longer.
Scientists think that may be due to other compounds in the herb, like polyphenols and flavonoids, who have antioxidant, fever reducing, antiseptic, and immune boosting properties.
http://umm.edu/health/medical/altmed/herb/willow-bark