1000x more lead in (1991) modern humans than pre-industrial humans. Lead & Cadmium as Cardiovascular Risk Factors: The Burden of Proof Has Been Met

cs3000

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The bone of a 20th century human has 1000‐fold more lead than that of a preindustrial human. Current sources of lead exposure to humans now result from soil, food, water, tobacco smoke and electronic cigarettes, lead‐based paints in and around older construction, and water pipes, to name a few.

Natural skeletal levels of lead in Homo sapiens sapiens uncontaminated by technological lead
^ bone lead in american indians skeletons from 700 & 1000 years ago vs levels in modern humans
(this study was before the ban on leaded gas - but i bet it's still many multiples above):


a mean natural body burden of 40 micrograms Pb/70 kg adult Homo sapiens sapiens, uncontaminated by technological Pb. This value is about one-thousandth of the mean body burden of 40 mg industrial Pb/70 kg adult American today, which indicates the probable existence within most Americans of dysfunctions caused by poisoning from chronic, excessive overexposures to industrial Pb.

A follow up study in canada assessing bone lead in 2010
ShieldSquare Captcha In 2010, an average person aged 57 years had a bone lead level approximately 1/3 less than their bone lead level age 40 years in 1993.


^ so can assume now reduced a lot compared to the 1991 study. but obviously completely depends on the individual (not just gas exposure). and it was so crazy high back then that even a massive reduction might still be too much.


Health effects of lead result from its ability to form strong bonds with proteins, and its interference with zinc and calcium (both divalent cations) dependent functions, particularly antioxidant functions and cellular signaling.22, 23, 24, 25 The interference with antioxidant function is of particular relevance. Lead directly and indirectly inhibits glutathione synthesis and function, and depresses superoxide dismutase activity, a zinc metalloprotein in humans.
Exposure to lead also results in epigenetic changes by inducing histone modifications. The half life of lead in cortical bone is approximately 30 years [7 - 26 years]. accumulation in bone remains as a continuous internal source of lead to the vascular endothelium and other tissues as it leaches out over decades of life.



The study found individuals with blood lead levels of 20 to 29 µg/dL experienced a 46% increase in all‐cause mortality compared with those with blood lead levels of <10 µg/dL. 20 mg/dl = 0.2 parts per million PPM

In NHANES III (1988–1994), patients with the highest tertile of blood lead (≥3.62 µg/dL) compared with the lowest tertile (<1.94 µg/dL) experienced a significantly higher risk of death during follow‐up. The increased risk was 25% for total mortality, 55% for cardiovascular mortality, 89% for myocardial infarction, and 151% for stroke

Signs and symptoms of chronic exposure include loss of short-term memory or concentration, depression, nausea, abdominal pain, loss of coordination, and numbness and tingling in the extremities (Patrick, 2006). Fatigue, problems with sleep, headaches, stupor, slurred speech, and anaemia are also found in chronic lead poisoning (Pearce, 2007). Children with chronic poisoning generally show aggressive behaviour and refuse to play.

Lead toxicity is an important environmental disease and its effects on the human body are devastating. There is almost no function in the human body which is not affected by lead toxicity.


Mind blown i'm only just finding out about this now. This ***t should be illuminated way more for the general public.
We probably want to make sure we're in the <10µg/dL / 0.1 parts per million group at the very least if not much lower .
. and this is just for 1 of the common toxic metals

How do blood levels relate to tissue levels? it varies but 0.1 PPM in blood = what range of PPM in nails or hair for example? i'd guess the "acceptable" ppm in tissues would be higher but not sure -
this mentions high levels in hair being 20 ppm
Lead concentrations in human tissues "Hair and nails were found to contain relatively high concentrations of lead, approximately 20 ppm" Lead concentrations in human tissues <- various tissue samples in this group, 0.22ppm in blood was paired with 18.44ppm in hair and 9.4 ppm in nails in men. in women 0.14ppm in blood was paired with 19.07ppm in hair.
 
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burtlancast

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Thanks for this.

Reminds me of the study showing decreased incidence of cancers among people treated with metal chelators over many months/years.

Even more reasons to take iodine (since it binds heavy metals in the blood),magnesium chloride (it increases excretion of heavy metals) and one bulb of garlic a day (it increases glutathione synthesis, which can bind heavy metals).
 
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InChristAlone

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Ascorbic acid has been shown to protect against lead poisoning.
 

dukesbobby777

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Thanks for this.

Reminds me of the study showing decreased incidence of cancers among people treated with metal chelators over many months/years.

Even more reasons to take iodine (since it binds heavy metals in the blood),magnesium chloride (it increases excretion of heavy metals) and one bulb of garlic a day (it increases glutathione synthesis, which can bind heavy metals).

How much iodine do you advise (if one were to try it)? Any good sources you know of?
 

Perry Staltic

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There's a lot less in the environment now than there used to be. It's been removed from paint, gasoline, pesticides, water pipes, etc.
 

InChristAlone

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There's a lot less in the environment now than there used to be. It's been removed from paint, gasoline, pesticides, water pipes, etc.
Unless you happen to live in an old house where the layers of paint were never removed. That can be a significant source of it.
 

burtlancast

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How much iodine do you advise (if one were to try it)? Any good sources you know of?

Dr Guy Abraham advises 2 drops a day for a steady state (intakes equals excretions).

As far as sources, i believe iodine has been made unavailable in all pharmacies throughout Europe, but you can still buy it over the internet, or even buy the ingredients to make it yourself.
 
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cs3000

cs3000

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Thanks for this.

Reminds me of the study showing decreased incidence of cancers among people treated with metal chelators over many months/years.

Even more reasons to take iodine (since it binds heavy metals in the blood),magnesium chloride (it increases excretion of heavy metals) and one bulb of garlic a day (it increases glutathione synthesis, which can bind heavy metals).

np , yeah glutathione looks like one of the keys. I havent found studies on iodine increasing metal excretion / lowering metal levels do u have some?
also what's your opinion on iodine & thyroid function? ray peat mentioned it lowers it even on "small" supplemented intake i think over a few hundred micrograms. and i remember seeing a study mentioning it affecting thyroid (maybe just initially or something?). but the japanese do have low rates of hypothyroidism with higher intakes so its confusing


Also another big key is Selenium. mainly for arsenic but also for lead & mercury. relates to glutathione too. well if not for increased excretion it at least protects against brain effects of elevated levels -> [Effect of lead and selenium on learning and memory ability in rats] - PubMed

Mercury Detox Using the Selenium Method In only those given the selenomethionine supplement, mercury level in pubic hair was lowered 34%, serum selenium rose by 73%, and blood selenium rose by 59%, on average <- Effect of supplementation with organic selenium on mercury status as measured by mercury in pubic hair - PubMed

Owing to the extremely high affinity between mercury and selenium, selenium sequesters mercury and reduces its biological availability. It is obvious that the converse is also true; as a result of the high affinity complexes formed, mercury sequesters selenium. This is important because selenium is required for normal activity of numerous selenium dependent enzymes. Through diversion of selenium into formation of insoluble mercury-selenides, mercury may inhibit the formation of selenium dependent enzymes while supplemental selenium supports their continued synthesis.



There's a lot less in the environment now than there used to be. It's been removed from paint, gasoline, pesticides, water pipes, etc.

Yeah it's massively reduced, but it's still higher that what humans have been exposed to throughout our existence as a species. and exposure levels fluctuate a lot based on the individual. even with a giant reduction in the air there's still lead flowing from aircraft, waste incineration, metals ore processing etc. the problem is 1. it stays in bone for so long, if you were born before the ban especially (i guess lead in air took a while to come down from day of the ban and probably still significantly elevated compared to 100+ 200+ years ago) you might still have elevated levels from this. even if bone levels dropped 80% in 2022 compared to back then they're still way higher than pre-industrial humans. lead is no good in the body.
and 2. unless tested we have no idea how much our individual exposure has been over time because there's almost zero systemic focus on this with doctors testing in spite of health affects being so drastic. manufacturers that cut corners, manufactured foods you've eaten over the years, lead in ceramics / crockery, foods coming from soil that happens to be crazy high in lead in your area,, contaminated supplements over years, water that tested fine when leaving the facility but by the time it got to your house through service pipes had crazy high amounts https://www.washingtonpost.com/educ...int-water-crisis-set-back-thousands-students/, etc. all adding up over years and also no insight how good your body is at excreting a % of it. And this is 1 of the metals.

Ascorbic acid has been shown to protect against lead poisoning.

yeh another one ive seen as part of protocols, i dont think its that effective at lowering lead (study in people showed -2%) but protective for the brain & liver.

thiamine b1 is another one that does increase excretion https://www.researchgate.net/public..._lead_levels_in_rats_Mechanism_of_interaction
Thiamin (vitamin B1) effects on lead intoxication and deposition of lead in tissues: Therapeutic potential
100mg per cow calf per day None of the control or Pb plus thiamin-treated calves showed clinical signs of poisoning and no deaths occurred. However, four of five Pb-treated calves showed signs of Pb poisoning and two died during the study. Tissues from both groups receiving Pb contained significantly higher (p < 0.01) concentrations of Pb than tissues from control calves. However, tissues from calves receiving Pb plus thiamin contained 2 to 10 times less Pb than tissues from calves receiving only Pb.
https://prevent-alzheimers-autism-s...1/targeted-lead-detox-with-thiamine-zinc.html

human study in this article
 
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Perry Staltic

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Yeah it's massively reduced, but it's still higher that what humans have been exposed to throughout our existence as a species.

We humans have a higher quality of life than what we've been exposed to throughout our existence as a species, eg, electricity. That comes with a price because real life has trade-offs. Thankfully our knowledge and technology have advanced to enable us to remove a lot of the toxic stuff, and hopefully that will continue. But we also must be realistic and realize the western world is also cleaner because of its deindustrialization that shifted much of that pollution to China.
 

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