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That's exactly what I was wondering about . Thanks.
OK, thanks!
Electron Microscopy | TEM vs SEM | Thermo Fisher Scientific - US
Electron microscopy reference focusing on the difference between transmission electron microscopes (TEM) and scanning electron microscopes (SEM).www.thermofisher.com
Do you mean not mix as in same day usage? What about every other day ie one day MB one day 10-Methoxy-Harmalan? Or do you mean you should only use one or the other products consistently over a period of time?
The chemical has already been discussed in another thread (see 1st link in References below), so this is just the announcement that it is now available for purchase.
The units listed on the label are just for measurement purposes. They do not indicate or suggest optimal dose. Please note that similar to the products sold by companies like BlueSky, this product if for lab/research use only. The product can be ordered from the link below:
http://www.idealabsdc.com/lab
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A naturally occurring (e.g. in tobacco) β-carboline derivative, 10-methoxy-harmalan (10-MeO-Harmalan) has been shown to act as a serotonin antagonist both in-vitro and in-vivo, with a mechanism and potency similar to the ergot derivatives, but without their psychotropic/hallucinogenic effects. In addition, several studies suggest dopaminergic effects of most naturally occurring β-carbolines. The chemical is currently not known to be regulated/restricted and is available commercially from a number of major chemical vendors.
Drops per container: about 250
Each drop contains the following ingredients:
10-MeO-Harmalan: 100 mcg
Other ingredients: add product to shopping cart to see info
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References:
10-methoxy-harmalan ,an anti-serotonin chemical?
Danny roddy and georgi dinkov discussed 10-methoxy-harmalan on the latest podcast ,which seems to be as anti-serotonin as LSD ,but without any hallucination effects . Anybody heard of it or knows where to get it? Let's compile some info!raypeatforum.com
"...A common feature of the immune cells of mammals and insects is the occurrence of serotonin receptors. Qi et al. [15] identified 5-HT1B, 5-HT2B, and 5-HT7 receptor expression in naive insect hemocytes, but only 5-HT1B and 5-HT2B appeared to have functional roles. While blockade of 5-HT1B significantly reduced phagocytic ability, blockade of 5-HT2B increased hemocyte phagocytosis. Harman and norharman are antagonists of both type 5-HT1 and 5-HT2 serotonin receptors,.."
Harman and norharman, metabolites of the entomopathogenic fungus Conidiobolus coronatus (Entomophthorales), affect the serotonin levels and phagocytic activity of hemocytes, insect immunocompetent cells, in Galleria mellonella (Lepidoptera) - Cell &
Background Although the β-carboline alkaloids harman and norharman are considered as plant metabolites, they can also be secreted by fungi such as the entomopathogen Conidiobolus coronatus. Norharman and harman are also known to be reversible competitive monamine oxidase inhibitors, which...cellandbioscience.biomedcentral.com
Stimulation, protection and regeneration of dopaminergic neurons by 9-methyl-β-carboline: a new anti-Parkinson drug? - PubMed
β-carbolines are potential endogenous and exogenous neurotoxins that may contribute to the pathogenesis of Parkinson's disease (PD). 9-methyl-β-carboline exhibits multimodal effects that could be beneficial in the treatment of PD. It shows stimulatory effects to dopaminergic neurons by...pubmed.ncbi.nlm.nih.gov
9-Methyl-β-carboline inhibits monoamine oxidase activity and stimulates the expression of neurotrophic factors by astrocytes - PubMed
β-Carbolines (BC) are pyridoindoles, which can be found in various exogenous and endogenous sources. Recent studies revealed neurostimulative, neuroprotective, neuroregenerative and anti-inflammatory effects of 9-methyl-BC (9-Me-BC). Additionally, 9-me-BC increased neurite outgrowth of...Error - Cookies Turned Off
onlinelibrary.wiley.com
Identification and occurrence of beta-carboline alkaloids in raisins and inhibition of monoamine oxidase (MAO) - PubMed
Monoamine oxidase (MAO) is a mitochondrial enzyme involved in the oxidative catabolism of neurotransmitters and xenobiotic amines, including vasopressor and neurotoxic amines, and a current target for antidepressant and neuroprotective drugs. Raisin extracts and homogenates exhibited reversible...
Interaction of β-carbolines with central dopaminergic transmission in mice: structure-activity relationships
Although several β-carboline alkaloids display hallucinogenic properties in humans, their mechanism of action remains unclear. To ascertain their infl…www.sciencedirect.com
my 5 cents. I think there is not enough info out there to compare them objectively. Cypro is very dirty drug with unneccesary antagonism of d2 and muscarinic receptors
I think it eventually led to this website .
