- Mar 20, 2021
My favorite supplement. I can eat without discomfort, and no side effects... It has improved my quality of life a great deal, so thank you haidut, and keep it coming.The chemical has already been discussed in another thread (see 1st link in References below), so this is just the announcement that it is now available for purchase.
The units listed on the label are just for measurement purposes. They do not indicate or suggest optimal dose. Please note that similar to the products sold by companies like BlueSky, this product if for lab/research use only. The product can be ordered from the link below:
A naturally occurring (e.g. in tobacco) β-carboline derivative, 10-methoxy-harmalan (10-MeO-Harmalan) has been shown to act as a serotonin antagonist both in-vitro and in-vivo, with a mechanism and potency similar to the ergot derivatives, but without their psychotropic/hallucinogenic effects. In addition, several studies suggest dopaminergic effects of most naturally occurring β-carbolines. The chemical is currently not known to be regulated/restricted and is available commercially from a number of major chemical vendors.
Drops per container: about 250
Each drop contains the following ingredients:
10-MeO-Harmalan: 100 mcg
Other ingredients: add product to shopping cart to see info
Danny roddy and georgi dinkov discussed 10-methoxy-harmalan on the latest podcast ,which seems to be as anti-serotonin as LSD ,but without any hallucination effects . Anybody heard of it or knows where to get it? Let's compile some info!raypeatforum.com"...A common feature of the immune cells of mammals and insects is the occurrence of serotonin receptors. Qi et al.  identified 5-HT1B, 5-HT2B, and 5-HT7 receptor expression in naive insect hemocytes, but only 5-HT1B and 5-HT2B appeared to have functional roles. While blockade of 5-HT1B significantly reduced phagocytic ability, blockade of 5-HT2B increased hemocyte phagocytosis. Harman and norharman are antagonists of both type 5-HT1 and 5-HT2 serotonin receptors,.."
Harman and norharman, metabolites of the entomopathogenic fungus Conidiobolus coronatus (Entomophthorales), affect the serotonin levels and phagocytic activity of hemocytes, insect immunocompetent cells, in Galleria mellonella (Lepidoptera) - Cell &Background Although the β-carboline alkaloids harman and norharman are considered as plant metabolites, they can also be secreted by fungi such as the entomopathogen Conidiobolus coronatus. Norharman and harman are also known to be reversible competitive monamine oxidase inhibitors, which...cellandbioscience.biomedcentral.com
Stimulation, protection and regeneration of dopaminergic neurons by 9-methyl-β-carboline: a new anti-Parkinson drug? - PubMedβ-carbolines are potential endogenous and exogenous neurotoxins that may contribute to the pathogenesis of Parkinson's disease (PD). 9-methyl-β-carboline exhibits multimodal effects that could be beneficial in the treatment of PD. It shows stimulatory effects to dopaminergic neurons by...pubmed.ncbi.nlm.nih.gov
9-Methyl-β-carboline inhibits monoamine oxidase activity and stimulates the expression of neurotrophic factors by astrocytes - PubMedβ-Carbolines (BC) are pyridoindoles, which can be found in various exogenous and endogenous sources. Recent studies revealed neurostimulative, neuroprotective, neuroregenerative and anti-inflammatory effects of 9-methyl-BC (9-Me-BC). Additionally, 9-me-BC increased neurite outgrowth of...pubmed.ncbi.nlm.nih.gov
Identification and occurrence of beta-carboline alkaloids in raisins and inhibition of monoamine oxidase (MAO) - PubMedMonoamine oxidase (MAO) is a mitochondrial enzyme involved in the oxidative catabolism of neurotransmitters and xenobiotic amines, including vasopressor and neurotoxic amines, and a current target for antidepressant and neuroprotective drugs. Raisin extracts and homogenates exhibited reversible...pubmed.ncbi.nlm.nih.gov
Interaction of β-carbolines with central dopaminergic transmission in mice: structure-activity relationshipsAlthough several β-carboline alkaloids display hallucinogenic properties in humans, their mechanism of action remains unclear. To ascertain their infl…www.sciencedirect.comElucidation of the structure of the endogenous ligand(s) for imidazoline binding sites, clonidine-displacing substance (CDS), has been a major goal for many years. Crude CDS from bovine lung was purified by reverse-phase high-pressure liquid chromatography. Electrospray mass spectrometry (ESMS)...pubmed.ncbi.nlm.nih.gov
Sounds good. I just bought the product. By the way, you can get free TLS certificates for idealabsdc.com and haidut.me using Let’s Encrypt. If you have SSH access to your webservers, it's really easy to do so (check the link and press "Get Started"). It’s worth setting it up if you have a few minutes.The main site is only text and pics. However, behind the scenes it used a shopping cart (IdeaLabs Online Store) and that one is secure. Once you get to the portion of the checkout where you have to enter payment info, address, etc it is done over HTTPS. If you have concerns even about the non-private data exchange, just use the link above instead of the main site. They are the same system under the hood.
Improving gut function seems to improve everything else as well. Domino effect. Any other supplements you're taking?
Excellent! I have the same problem and thyroid hormones did nothing to combat that. When I feel great and calm I never have this problem. Looking forward to trying this!I am putting 1-2 drops under my tongue for mild anti-serotonin effects in the evening. Works well: I second @Mauritio for relaxed chill mood and @LadyRae for the feeling of warmth.
My fingers prone to a mild Raynaud's syndrome in the winter. I figured out some time ago that this is due to increased serotonin and decided to try 10MH now instead of my standard method of increasing my CO2. After taking 2 drops, I could see almost immediately how blood rises up the whitish fingers and they became warm.
How many drops have you been taking? Very interesting that taking it orally for you greatly improved your digestion. I wonder if that is simply because it blocks the serotonin that is created in the gut or it has some indirect antibiotic effect that improves the gut.
Orally, but wipe any extra from tip of bottle on paw, so about 2 drops a day for a week to to ten days, then a few days off. As for feeding, not sure calorie wise, but probably, if he were a human, approx. 2500-3000 cal a day... Forgot to mention I also experimented with cypro. lusaride, and metergoline, all worked but with not quit feeling right, either unnaturally amped up or crushingly demotivated, where 10-har effects for him are on digestion only, so he just feels normal, if that makes any sense..Does your lab rat take it orally? How much are you feeding your rat and how often?
Orally, but wipe any extra from tip of bottle on paw, so about 2 drops a day for a week to to ten days, then a few days off. As for feeding, not sure calorie wise, but probably, if he were a human, approx. 2500-3000 cal a day... Forgot to mention I also experimented with cypro. lusaride, and metergoline, all worked but with not quit feeling right, either unnaturally amped up or crushingly demotivated, where 10-har effects for him are on digestion only, so he just feels normal, if that makes any sense..
Yes... The effects even out, then I stop administering to the subject until symptoms return, then start again... The break is anywhere between 2-5 days. There is a very little slowing of subjects bowelsMy rat reacted to the metergoline with tiredness and slowing bowels. Lisuride same.
Do you find you have to cycle off with your rat the way you are, taking a few days off?
Yes, my rat...your lab rat, you mean