tph

  1. haidut

    Blocking Serotonin May Treat Allergies And Inflammatory Diseases

    The bad news for serotonin (5-HT) just keeps accumulating. Aside from its well-known (outside of medical office, of course) effects on causing pretty much any mental illness defined in DSM V, as well as fibrosis in any organ/tissue unfortunate enough to be exposed to 5-HT now we can add...
  2. haidut

    Serotonin Causes Anhedonia. And Mental Illness In General

    As many of my readers know, anhedonia is one of the most pernicious symptoms of most mental disorders, and is perhaps the most resistant to therapy. It also happens to be one of the main triggers of attempted suicide, based on interviews with suicide survivors. I posted some threads in the past...
  3. haidut

    Serotonin (due To Bacteria) Is The Master Regulator Of Metabolism, Insulin Sensitivity, And Weig

    Over the last year I posted a number of studies demonstrating strong link between serotonin and chronic conditions such as obesity, insulin resistance, and even diabetes. Augmented capacity for peripheral serotonin release in human obesity...
  4. haidut

    Colon Aging / Cancer? Due To Low NAD / High Serotonin; Niacinamide Reverses Both

    Peat has said many times that the impaired bowel regularity that occurs in aging, hypothyroidism and various pathologies is due to high NO and serotonin. He also said that while serotonin inhibits motility in the colon it increases it in the small intestine. Most doctors do not agree with that...
  5. haidut

    Vitamin D May Be A Viable Therapy For Autism (human Study)

    This is one of the rare human studies using direct intervention for autism. As you can see, there was significant improvement in symptoms with a dose of 300 IU / kg of bodyweight, given daily for 4 months. In addition to the pro-metabolic effects of vitamin D, it is also a known inhibitor of TPH...
  6. haidut

    Metergoline - Liquid Serotonin Antagonist For Lab/R&D

    This chemical metergoline is a very interesting substance and is a continuation of my search for chemicals that combine several beneficial characteristics into a single molecule/entity. Metergoline belongs to the same class of drugs as bromocriptine, lisuride, cabergoline, terguride, etc...
  7. haidut

    Inhibiting Serotonin During Protein Feeding Doubles Maximum Lifespan

    This study is actually on the effects of a high protein diet on brain neurotransmitters and lifespan. It was done in fruit flies but the serotonin in those fruit flies are essentially the same in humans. So, the results should hold. One of the big takeaways from the study is the explanation of...
  8. haidut

    Children With Autism Have High Serotonin Levels

    I posted a few studies on using anti-serotonin drugs (specifically 5-HT2 antagonists) as a potential treatment for autism. This study adds more weight to the evidence for causative role of serotonin in autism by finding out that children with autism have abnormally high blood serotonin levels...
  9. haidut

    Maternal Inflammation Causes Brain Damage (autism) By Raising Serotonin

    I posted several studies recently about maternal hypothyroidism and stress being linked to autism, as well as the use of serotonin antagonist to reverse autism pathology in an animal model. This study adds more weight to the serotonin-autism connection. It showed that triggering flu-like...
  10. haidut

    Depression May Be Caused By Estrogen In Females And Cortisol In Males

    A very interesting study, which points to a potential difference in the depression etiology between the sexes. However, given that cortisol is one of the strong activators of the aromatase enzyme, high cortisol also means high estrogen in males. The study openly discusses the effect of stress on...
  11. haidut

    DHT Lowers Serotonin Synthesis, May Treat (testicular) Cancer

    This is a great study for a number of reasons. 1. First, it suggests that DHT is not the evil substances for male reproductive organs. This includes prostate cancer, for which DHT to this day is cite as the main culprit. 2. Second, the study establishes the key role serotonin plays in the...
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