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tph

  1. haidut

    Lowering/blocking serotonin is therapeutic for cancer

    One of the few studies that is brave enough to point the finger directly at serotonin as a tumor-promoter. Mainstream medicine has acknowledged that serotonin has a growth-promoting effects, but only in one specific tumor - carcinoid syndrome - and refuses to admit that the same growth-promoting...
    • haidut
    • Thread
    • 5-ht cancer colon immune system pancreatic serotonin t-cell tph
    • Replies: 2
    • Forum: Scientific Studies
  2. Mauritio

    Sterile gut leads to lower anxiety, serotonin , and TPH-levels + some bacteria don't increase serotonin

    This study says: Beyond the gut, germ free mice also display an increased turnover rate of dopamine and norepinephrine (as well as serotonin) in the brain (Diaz Heijtz et al., 2011), which could generally reduce pools in systemic circulation independent of microbial production (although factors...
  3. haidut

    Blocking Serotonin May Treat Allergies And Inflammatory Diseases

    The bad news for serotonin (5-HT) just keeps accumulating. Aside from its well-known (outside of medical office, of course) effects on causing pretty much any mental illness defined in DSM V, as well as fibrosis in any organ/tissue unfortunate enough to be exposed to 5-HT now we can add...
    • haidut
    • Thread
    • 5-ht allergy cause inflammation promote serotonin tph tryptophan hydroxylase
    • Replies: 7
    • Forum: Scientific Studies
  4. Mauritio

    Serotonin Causes Obesity, Diabetes, Fibrosis,liver Damage ,increases Endotoxin And NO

    Inspired by this thread Serotonin/endotoxin/PUFA As Primary Causes Of Depression And Diabetes; Can Be Easily Blocked I was reading a few more recent studies on the detrimental effect of serotonin on ones health. It seems clear that by now it is known in medicine, that blocking it is highly...
    • Mauritio
    • Thread
    • diabetes endotoxin fibrosis nitric oxide no obesity serotonin tlr4 tph tph inhibitor
    • Replies: 7
    • Forum: Scientific Studies
  5. haidut

    Serotonin Causes Anhedonia. And Mental Illness In General

    As many of my readers know, anhedonia is one of the most pernicious symptoms of most mental disorders, and is perhaps the most resistant to therapy. It also happens to be one of the main triggers of attempted suicide, based on interviews with suicide survivors. I posted some threads in the past...
    • haidut
    • Thread
    • anhedonia cause chronic stress depression mental illness serotonin social defeat stress tph
    • Replies: 2
    • Forum: Scientific Studies
  6. haidut

    Serotonin (due To Bacteria) Is The Master Regulator Of Metabolism, Insulin Sensitivity, And Weig

    Over the last year I posted a number of studies demonstrating strong link between serotonin and chronic conditions such as obesity, insulin resistance, and even diabetes. Augmented capacity for peripheral serotonin release in human obesity...
    • haidut
    • Thread
    • 5-ht bacteria colon diabetes gut inflammation insulin resistance microbiome obesity pathological serotonin sibo tph
    • Replies: 31
    • Forum: Scientific Studies
  7. haidut

    Colon Aging / Cancer? Due To Low NAD / High Serotonin; Niacinamide Reverses Both

    Peat has said many times that the impaired bowel regularity that occurs in aging, hypothyroidism and various pathologies is due to high NO and serotonin. He also said that while serotonin inhibits motility in the colon it increases it in the small intestine. Most doctors do not agree with that...
    • haidut
    • Thread
    • 5-ht4 aging colon colon cancer niacinamide nmn serotonin serotonin uptake sert tph tph2
    • Replies: 30
    • Forum: Scientific Studies
  8. haidut

    Vitamin D May Be A Viable Therapy For Autism (human Study)

    This is one of the rare human studies using direct intervention for autism. As you can see, there was significant improvement in symptoms with a dose of 300 IU / kg of bodyweight, given daily for 4 months. In addition to the pro-metabolic effects of vitamin D, it is also a known inhibitor of TPH...
    • haidut
    • Thread
    • autism children cholecalciferol human serotonin study therapeutic therapy tph vitamin d vitamin d3
    • Replies: 16
    • Forum: Scientific Studies
  9. haidut

    Metergoline - Liquid Serotonin Antagonist For Lab/R&D

    This chemical metergoline is a very interesting substance and is a continuation of my search for chemicals that combine several beneficial characteristics into a single molecule/entity. Metergoline belongs to the same class of drugs as bromocriptine, lisuride, cabergoline, terguride, etc...
    • haidut
    • Thread
    • antifungal candida dopamine dopamine agonist metergoline serotonin serotonin antagonist tph trh
    • Replies: 888
    • Forum: IdeaLabs
  10. haidut

    Inhibiting Serotonin During Protein Feeding Doubles Maximum Lifespan

    This study is actually on the effects of a high protein diet on brain neurotransmitters and lifespan. It was done in fruit flies but the serotonin in those fruit flies are essentially the same in humans. So, the results should hold. One of the big takeaways from the study is the explanation of...
    • haidut
    • Thread
    • 5-ht2 caloric restriction doubles food inhibition lifespan perceived protein reward serotonin starvation tph
    • Replies: 12
    • Forum: Scientific Studies
  11. haidut

    Children With Autism Have High Serotonin Levels

    I posted a few studies on using anti-serotonin drugs (specifically 5-HT2 antagonists) as a potential treatment for autism. This study adds more weight to the evidence for causative role of serotonin in autism by finding out that children with autism have abnormally high blood serotonin levels...
  12. haidut

    Maternal Inflammation Causes Brain Damage (autism) By Raising Serotonin

    I posted several studies recently about maternal hypothyroidism and stress being linked to autism, as well as the use of serotonin antagonist to reverse autism pathology in an animal model. This study adds more weight to the serotonin-autism connection. It showed that triggering flu-like...
    • haidut
    • Thread
    • brain damage child children inflammation maternal neurodegeneration offspring serotonin tph tph1 tryptophan hydroxylase
    • Replies: 18
    • Forum: Scientific Studies
  13. haidut

    Depression May Be Caused By Estrogen In Females And Cortisol In Males

    A very interesting study, which points to a potential difference in the depression etiology between the sexes. However, given that cortisol is one of the strong activators of the aromatase enzyme, high cortisol also means high estrogen in males. The study openly discusses the effect of stress on...
    • haidut
    • Thread
    • cortisol crf depression estrogen female males serotonin tph tph1
    • Replies: 35
    • Forum: Scientific Studies
  14. haidut

    DHT Lowers Serotonin Synthesis, May Treat (testicular) Cancer

    This is a great study for a number of reasons. 1. First, it suggests that DHT is not the evil substances for male reproductive organs. This includes prostate cancer, for which DHT to this day is cite as the main culprit. 2. Second, the study establishes the key role serotonin plays in the...
  15. W

    Inhibition Of Peripheral Serotonin Production Protects From Diet-induced Obesity And Related Complic

    Don't known if someone has already mentioned this recent news from this particular study here already or not, but definitely another point for Dr. Ray Peat. "Obesity is a major risk factor for chronic disease. A new study in mice reveals that lowering levels of the signaling molecule serotonin...
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