• Due to excessive bot signups along with nefarious actors we are limiting forum registration. Keep checking back for the register link to appear. Please do not send emails or have someone post to the forum asking for a signup link. Until the current climate changes we do not see a change of this policy. To join the forum you must have a compelling reason. Letting us know what skills/knowledge you will bring to the community along with the intent of your stay here will help in getting you approved.


  1. NewACC

    Role of Cholinergic and Dopamine Receptors in the Physiology of Caffeine Tolerance

    Dear Forum Members, I found three interesting studies on reversing (or reducing) caffeine tolerance, by adding to chronic (or sub-chronic) caffeine treatment, either the dopamine agonists bromocriptine (a predominantly d2/d3 family agonist) or pergolide (a very potent d1 agonist), or...
  2. FitnessMike

    Can You Build Tolerance With Daily Usage Of 5-10mg Of Progesterone Cream?

    as above
  3. haidut

    Loneliness Increases Alcohol Tolerance, May Explain "addiction"

    I posted several studies in the past about the connection between stress hormones and "addiction", especially alcohol. This new study adds more evidence to that link and now also draws serotonin in the picture. Apparently, social creatures are much more sensitive to inebriation effects of...
  4. DaveFoster

    Tolerance Builds To Caffeine-Induced Anxiety

    The first of the following two studies was done on rats, and the second on humans. It seems that after about 2 weeks, the anxiogenic effects of caffeine diminishes completely as tolerance develops. Coincidentally, this is the time that it takes adenosine receptors to fully upregulate to...
  5. haidut

    Full Tolerance To Stress Response Of Caffeine Within 4 Days

    Event the people who find that caffeine gives them a "stress response" or raises their blood pressure, cortisol, etc should be able to quickly adapt. This study shows complete adaptation to all parameters of the "stress response" induced by 250mg caffeine daily. The adaptation occurred in as...