tnf

  1. haidut

    Pregnenolone Is A Potent (functional) Endotoxin (TLR4) Antagonist

    It seems that pregnenolone is finally starting to look exciting to the medical industry. In addition for its intensive studies for a variety of mental issues, now studies are coming out demonstrating its endotoxin (LPS) antagonism effects. As most forum users know, endotoxin exerts its effects...
  2. haidut

    Stress Exacerbates Cancer And Speeds Up Its Progression

    The study is only about leukemia, but it adds to other evidence I have posted before on the role of stress in cancer development and progression. Stress (adrenaline, Noradrenaline) As The Main Driver Of Cancer Metastases Bad Environment & Lifestyle (stress) Cause Most Cancers In Western...
  3. P

    Effect Of Boron On Thymic Cytokine Expression, Hormone Secretion, Antioxidant Functions, Cell Prolif

    Effect of Boron on Thymic Cytokine Expression, Hormone Secretion, Antioxidant Functions, Cell Proliferation, and Apoptosis Potential via the Extrac... - PubMed - NCBI J Agric Food Chem. 2017 Dec 27;65(51):11280-11291. doi: 10.1021/acs.jafc.7b04069. Epub 2017 Dec 18. Effect of Boron on Thymic...
  4. P

    Nothing Boring About Boron

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712861/ The trace mineral boron is a micronutrient with diverse and vitally important roles in metabolism that render it necessary for plant, animal, and human health, and as recent research suggests, possibly for the evolution of life on Earth. As...
  5. P

    Low Dose Doxycycline Decreases Systemic Inflammation And Improves Glycemic Control, Lipid Profiles,

    Low dose doxycycline decreases systemic inflammation and improves glycemic control, lipid profiles, and islet morphology and function in <i>db/db</i> mice Low dose doxycycline decreases systemic inflammation and improves glycemic control, lipid profiles, and islet morphology and function in...
  6. P

    Lidocaine Effect On Tnf Alpha And Nitrite After Endotoxin Exposure

    Effect of inhaled and intravenous lidocaine on inflammatory reaction in endotoxaemic rats. - PubMed - NCBI Eur J Anaesthesiol. 2010 Jan;27(1):53-60. doi: 10.1097/EJA.0b013e32832b8a70. Effect of inhaled and intravenous lidocaine on inflammatory reaction in endotoxaemic rats. Flondor M1, Listle...
  7. P

    TNF Alpha

    I probably will edit this post and update it. Magnesium and tnf alpha interaction Elevated concentrations of TNF-alpha are related to low serum magnesium levels in obese subjects. - PubMed - NCBI Adequate zinc intake is necessary for protection against tnf alpha and pufa Zinc nutrition and...
  8. Diokine

    Role Of Nervous System In Rheumatoid Arthritis – Acetylcholine And TNF-alpha

    The inflammatory condition, called rheumatoid arthritis or rheumatism, is marked by degeneration and pain in the joints, muscles, and connective tissues. The disease shares many traits with other inflammatory “autoimmune” conditions like multiple sclerosis and lupus, but is especially associated...
  9. P

    Brain Insulin Resistance Identified As Possible New Link Between Alzheimer's Disease, Diabetes

    It says brains inability to burn glucose is responsible for Alzheimer's disease.caused by insulin's resistance in brain, and that probably mediated by inflammation. Brain Insulin Resistance Contributes to Cognitive Decline in Alzheimer's Disease – PR News...
  10. P

    Inflammation Mediates Free Fatty Acid-induced Insulin Resistance

    JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes. - PubMed - NCBI Lipid infusion and high fat feeding are established causes of systemic and adipose tissue insulin resistance. In this study, we treated 3T3-L1 adipocytes with a mixture...
  11. P

    Saturated Fatty Acids,including Lauric Acid Activates TLR4

    Some studies showing coconut oil has anti stress effects,but this one surprised me! Fatty Acids Modulate Toll-like Receptor 4 Activation through Regulation of Receptor Dimerization and Recruitment into Lipid Rafts in a Reactive Oxygen Species-dependent Manner The saturated fatty acids...
  12. P

    Voluntary Activation Of The Sympathetic Nervous System And Attenuation Of The Innate Immune Response

    Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans. - PubMed - NCBI Excessive or persistent proinflammatory cytokine production plays a central role in autoimmune diseases. Acute activation of the sympathetic nervous system attenuates...
  13. DaveFoster

    Aspirin Protects The Brain Against Stress

    Aspirin inhibits stress-induced increase in plasma glutamate, brain oxidative damage and ATP fall in rats. - PubMed - NCBI The precise mechanisms by which stress induces brain damage are still being elucidated. The high-output, inducible isoform of nitric oxide (NO) synthase (iNOS) is...
  14. P

    Iron Decreases Adiponectin - Phlebotomy(blood Donation),Manganese,zinc,vitamin D Increasing It

    Adipocyte iron regulates adiponectin and insulin sensitivity. - PubMed - NCBI Iron overload is associated with increased diabetes risk. We therefore investigated the effect of iron on adiponectin, an insulin-sensitizing adipokine that is decreased in diabetic patients. In humans, normal-range...
  15. haidut

    Glycine Is An Endotoxin (TLR4) Antagonist

    We can now add glycine to the substances that inhibit endotoxin or its effects. The endotoxin antagonism probably explains a good deal of glycine's protective effects on the liver from all sorts of assaults, but especially ethanol/alcohol (which is a known TLR4 agonist). The in-vivo study used a...
  16. haidut

    Glycine May Treat Type II Diabetes In Humans

    Human study, with a moderate dose of glycine. Ray wrote several times about the usage of gelatin as treatment for even type I diabetes. Unfortunately, the practice was abandoned in the early 20th century in favor of more toxic therapies or insulin injections. This human study shows that a...
  17. M

    Depression/Anxiety Caused By Systemic Inflammation?

    I came across this interesting article* today. There's something appealing in the idea that awful things like depression, and potentially anxiety, could ultimately come down to inflammation caused by seed oils and such, perhaps because, if true, it should be a simple problem to overcome. Stop...
  18. haidut

    DHEA Protects From Endotoxin Effects And Lethality

    Sepsis is the leading cause of death in patients hospitalized for infections. There is no accepted treatment, at least officially, that can change the course of the sepsis for the better. This study shows that a single HED dose of as little as 5mg - 7mg daramatically increased survival from a...
  19. haidut

    Vitamin B2 (riboflavin) Is Endotoxin (LPS / TLR4) Antagonist

    This is just a follow up on the recent post on both riboflavin and vitamin D. Vitamin B2 Remarkably Effective Against Endotoxin, Sepsis, And Other Bacterial Infections https://raypeatforum.com/community/threads/vitamin-d-is-endotoxin-lps-tlr4-antagonist-may-treat-lps-linked-conditions.12060/...
  20. haidut

    Vitamin D Is Endotoxin (LPS / TLR4) Antagonist, May Treat LPS-linked Conditions

    The activation of TLR by various substances like endotoxin, ethanol / alcohol, opioids, SSRI, etc is involved in the pathogenesis of many conditions, especially IBD, colon cancer, periodontal disease, etc. There are very few effective endotoxin antagonists in clinical use, which is unfortunate...
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