• Rest in Paradise,
    Raymond Franklin Peat October 12, 1936 - November 24, 2022

    Remembering Ray Peat Call-In Show with Georgi Dinkov

    Ray Peat Email Advice Depository

  • tca300: I understand this is off topic from what you typically teach, but I was wondering if you have run across any information or learned on your own, things that help people grieve over lost loved ones, and or fear of losing others to death? Thank you!

    Ray Peat: It activates the “helplessness” reactions in the body, stress weakening your own life, and I think it can help to get out of that if you think of your life as a continuation of theirs—the same life, though with fewer bodies.

    Rest in Paradise, Raymond Peat  October 12, 1936 - November 24 2022

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t3

  1. Hans

    The easiest way to optimize DHT (thyroid optimization)

    https://men-elite.com/2022/11/22/the-easiest-way-to-optimize-dht-thyroid-optimization/
  2. A

    Subclinical hypothyroidism dosage

    My TSH is elevated (from 4.4-6.6, reference: 0.4-4), while free T4 and T3 is normal. What dosage of T4 should I use? And should I include T3?
  3. copycat

    Thyroid dosage, looking for friendly advice

    TL;DR: Decided to experiment with Tyromix. Admittedly I simply skimmed over the dosage protocol Ray recommends lmao, not very wise. took about 20 drops of Tyromix total in the span of 3 days(120 mcg T4, 60cmg T3). Expecting some reverseT3(??) and difficulties for my body to adjust to the crazy...
  4. Cameron

    T3 increases 5-AR type 1

    “In addition, in Silurana (Xenopus) tropicalis whole body larvae, T3 increases the expression of androgen-related genes, 5α-reductase type 1 (srd5alpha1) and ar (16). Therefore, the present study aimed to investigate whether TH- and sex steroid-related genes are also regulated by T3 in the brain...
  5. Drareg

    TUDCA and phenylbutyric acid accelerate thyroid hormone activation and energy expenditure

    Interesting study, combining both substances should have a positive effect. 21237159 Exposure of cell lines endogenously expressing the thyroid hormone activating enzyme type 2 deiodinase (D2) to the chemical chaperones tauroursodeoxycholic acid (TUDCA) or 4-phenylbutiric acid (4-PBA) increases...
  6. Mr Joe

    Will T3 on low pulse make it lower ?

    Ray and @haidut have mentionned that taking t3 for hypo people with high pulse could first decrease the pulse because of adrenalin. If someone in the other hand is hypo with low pulse (60) and low CO2 production, is taking t3 could decrease that pulse to 50 or so ? Could someone share some...
  7. Brandin

    Creating a therapeutic systematic health boosting combo

    I am experimenting with creating a combination of supps that would compliment eachothers effect and hopefully even inhibiting eachothers bad effects. Question 1: Anybody knows if taking a dopamine d2 agonist with higher affinity for the receptors than cypro would lead to cypro not binding to...
  8. Sitaruîm

    Trying to Help my Mom (Hypothyroidism)

    For some years now my mom has been taking Levothyroxine (T4) for her hypothyroidism. She is also bipolar and takes Risperidone and Valcote (sodium valproate). She is pretty functional and active but the main problem that I see is that she sleeps a lot, anywhere from 10 to 12 hours every night...
  9. Cameron

    Androgenic effects of T3 supplementation any experiences?

    “Thyroid hormones are important for growth and development of many tissues. Altered thyroid hormone status causes testicular abnormalities. For instance, juvenile hypothyroidism=neonatal transient hypothyroidism induces macroorchidism, increases testicular cell number (Sertoli, Leydig, and germ...
  10. RenaissanceMan

    Nose bleeds from T3? Help!

    What could be the reason I am getting nose bleeds after recently starting T3 supplementation? Is this a sign that I'm taking too much or that I need to take T4 with it as well?
  11. RenaissanceMan

    Thoughts on Vitamin A Supplementation alongside T3?

    What do you think about Vitamin A supplementation in general and taking it alongside T3? And if you had to choose between taking vitamin A with Thyroid or aspirin with Thyroid, which one would you choose and why?
  12. RenaissanceMan

    Breaking Apart Cynomel Tabs (T3) and Weighing Doses?

    Anyone have advice on storing and breaking apart these tiny tablets, it seems like it'll get tedious after a while Also do you think it's worth buying a scale to take precise doses?
  13. RenaissanceMan

    Triyotex now sells 10 mcg T3 dosage. Are they legit?

    Triyotex now has 10 mcg Cytomel (T3) available. This might be more convenient for many of us instead of ordering Cynomel and splitting the tablets up. Are they legit, though? Suppose there's only one way to find out Might order 2 of them. If someone wants to me to update after I receive the...
  14. RenaissanceMan

    Did I make a mistake by getting T3 only?

    I placed an order from the Mexican pharmacy a few days ago and they already shipped it! Most likely because I paid extra for fast shipping. The thing is, I only bought Cynomel (T3). I’ve had hypo symptoms for so many years and I’m finally taking the plunge into thyroid medicine. Thinning hair...
  15. P

    Day 7 of thyroid supplementation, few questions

    Hello all, I have been taking T4/T3 (2:1 ratio) for seven days now, slowly titrating up. I began with 3 mcg T3 and 6 mcg T4 once daily and now am up to triple both doses on day 7 (too fast?), split into three doses throughout my day. I have upped my calories and I am including as many nutrients...
  16. FitnessMike

    TYRONENE VS CYNOMEL EXPERIENCE?

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  17. FitnessMike

    Your experiences with low dose t3?

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  18. Randle Cyclist

    Cinnamon Lowers Serum T3?

    https://pubmed.ncbi.nlm.nih.gov/26374392/ Has anyone come across this study before? I don't have access to the full study but it would appear cinnamon lowers circulating levels of T3. Based on the keywords, I believe Ceylon cinnamon was used. The human equivalent dose, about 65mg per kg, is...
  19. Mauritio

    Uncoupling increases T3

    It has long been shown that T3 increases uncoupling ,but this study shows that it also works vice versa : Uncoupling (through BAT activation) increases deiodinase type 2 ,which catalyzes T4 toT3 conversion . This should create a positive feedback loop. If you uncouple your metabolism with...
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