study

  1. M

    Methylene Blue Decreases MARK4-mediated Tau Phosphorylation In A Dose Dependent Manner

    Another study investigating methylene blue as a treatment option for Alzheimer's disease. Sun et al. (2016) Attenuation of synaptic toxicity and MARK4/PAR1-mediated Tau phosphorylation by methylene blue for Alzheimer’s disease treatment. Scientific Reports 6:34784 MB effects were explored in...
  2. haidut

    Vitamins B2 And B12 Protect Against GI Cancer

    Even though this is officially considered an epidemiological study, it was a lot more controlled than that. The patients were given vitamin supplementation and compliance was enforced as much as possible. So, you can call this an open label trial. And given that the population studied was one...
    • haidut
    • Thread
    • cancer esophageal gastric gi reduction risk study throat vitamin b12 vitamin b2 vitamins
    • Replies: 3
    • Forum: Scientific Studies
  3. haidut

    Low-dose Glycine As Stroke Treatment In Humans

    The mainstream therapy for (non-hemorrhaging) stroke is a IV anticoagulants like warfarin, or a baby aspirin within the first few hours of getting stroke symptoms while the person is on her/his way to the hospital. These two studies show that sublingual glycine in a dose of 1g-2g within the...
    • haidut
    • Thread
    • glycine humans ischemic morbidity mortality protective stroke study treatment
    • Replies: 2
    • Forum: Scientific Studies
  4. J

    DHEA-S Associated With MPB

    Danny Roddy just posted the following: https://t.co/d3k6taYCfC This makes me wonder whether Pansterone is contributing to a recent bout of hair loss. I initially felt good on Pansterone, but now don't notice much on ~2-3 drops a day. Perhaps I have too much DHEA/DHEAs. Or maybe it's just a...
  5. raypeatclips

    TLR4 (endotoxin) Link To Coronary Artery Disease

    TLR4 signaling: a potential therapeutic target in ischemic coronary artery disease. - PubMed - NCBI "Toll-like receptor 4 (TLR4), a primary receptor of the innate immune system, plays a pivotal role in the initiation and progression of atherosclerosis. " " Here we summarize recent progress on...
  6. raypeatclips

    Osteoarthritis Link To TLR4 Signaling (Endotoxin)

    Someone please correct me if I am wrong but thanks to haidut seen TLR4 signalling is highly involved with endotoxin, which, from this brief abstract seems to discuss a link between this and osteoarthritis. TLR4 signalling in osteoarthritis--finding targets for candidate DMOADs. - PubMed - NCBI
  7. haidut

    Genomic Mechanism For Beneficial Effects Of Progesterone On Pregnancy / Cancer

    Apparently, the gene Gata2 is crucial for the protective effects of progesterone against estrogen carcinogenicity, as well as for ability to enable pregnancy formation. GATA2 - Wikipedia This study found that progesterone acts as a Gata2 agonist and absence of the gene makes mice infertile as...
    • haidut
    • Thread
    • cancer estrogen fertility gata2 genes pregnancy progesterone study uterine uterus
    • Replies: 2
    • Forum: Scientific Studies
  8. haidut

    Low-dose Glycine May Treat Alcoholic Delirium / Hallucinosis In Humans

    The symptoms of alcohol withdrawal and its associated delirium are due mostly to serotonin overload and functional GABA deficiency. As such, anti-serotonin drugs can be very beneficial but they often have side effects and cannot be freely obtained. This human study showed that a single...
    • haidut
    • Thread
    • alcohol alcoholism delirium glycine hallucinosis inhibition neurotransmitter study withdrawal
    • Replies: 7
    • Forum: Scientific Studies
  9. haidut

    Glycine Is An Endotoxin (TLR4) Antagonist

    We can now add glycine to the substances that inhibit endotoxin or its effects. The endotoxin antagonism probably explains a good deal of glycine's protective effects on the liver from all sorts of assaults, but especially ethanol/alcohol (which is a known TLR4 agonist). The in-vivo study used a...
    • haidut
    • Thread
    • antagonist endotoxin glycine lipopolysaccharide liver lps study tlr4 tnf
    • Replies: 37
    • Forum: Scientific Studies
  10. haidut

    Glycine May Treat Type II Diabetes In Humans

    Human study, with a moderate dose of glycine. Ray wrote several times about the usage of gelatin as treatment for even type I diabetes. Unfortunately, the practice was abandoned in the early 20th century in favor of more toxic therapies or insulin injections. This human study shows that a...
    • haidut
    • Thread
    • a1c blood glucose diabetes glycine inflammation study tnf
    • Replies: 29
    • Forum: Scientific Studies
  11. haidut

    Glycine Protects From Iron Toxicity In The Liver

    The optimal approach would be to keep iron stores on the low end of normal but for the people who already have confirmed iron overload, this study may offer some help. Glycine seems to protect from the toxicity of iron, which is mainly manifested in the liver (and sometimes brain). Iron induces...
  12. haidut

    Theanine May Treat Depression In Humans

    It is a human study, and it used a relatively low dose theanine - only 250mg daily for 8 weeks. Theanine improved virtually all symptoms including actual symptoms of depression, anxiety, and cognitive function. I wonder what would double that dose have achieved given the study I posted about...
    • haidut
    • Thread
    • anxiety cognitive function depression dopamine human major depression mdd serotonin study theanine
    • Replies: 35
    • Forum: Scientific Studies
  13. haidut

    The Universe Is NOT Expanding At An Accelerated Rate

    Yet another one of the "breakthrough" discoveries like dark matter, dark energy, and gravitational waves appears to be false and prematurely hailed. The work of Halton Arp and Jayant Narlikar wastes away in obscurity, while the well-funded frauds of physics proliferate their fake knowledge...
    • haidut
    • Thread
    • acceleration expansion nobel prize steady steady state study universe wrong
    • Replies: 39
    • Forum: Scientific Studies
  14. haidut

    A Piece Of Dough Can Learn Just Like Animals And Humans

    Remarkable study, showing that there may not be that much difference between what is in our heads and that cold rock lying by the road. The learning occurred through change of structure within the matter and required proper timing - i.e. both of these phenomena are required for learning in...
    • haidut
    • Thread
    • animals complexity dough humans learning matter structure study
    • Replies: 90
    • Forum: Scientific Studies
  15. haidut

    Fertility Problems In Women Could Be Due To High Cortisol

    Cortisol is highly antagonistic to progesterone - i.e. it both directly inhibits synthesis of progesterone and activates aromatase, so elevated cortisol results both in deficiency of progesterone and excess of estrogen. This human study found that women who had issues getting pregnant had...
  16. Parsifal

    Germ-free Animals Have Autistic Like Behaviors And No Resistance To Stress

    "Germ-free animals, which are bred and raised to be sterile and have no gut microbiota, have distinctly unhuman characteristics: disrupted sociability, autistic like behavior, poor cardiac output, atrophied organs (heart, liver, and brains), constant feeding behavior, and, ironically, poor gain...
  17. haidut

    Unsaturation = Estrogenic, Saturation = Androgenic

    Most people on the forum have read Peat's articles on PUFA and its great synergism with the estrogenic hormones. Peat has written that saturated fats have effects opposite to those of PUFA and there are studies showing feeding saturated fat increases androgen synthesis. I have been researching...
    • haidut
    • Thread
    • androgenic androstenedione androsterone estrogenic estrone saturation steroid steroids study testosterone unsaturation
    • Replies: 23
    • Forum: Scientific Studies
  18. haidut

    Estrogen Or Anti-androgen Therapy Shrinks Brain And Destroys Grey Matter

    This was a human study and one of the very few to look at steroid effects on the brain as a result of supplementation. As the study said, the results are very relevant for all women who take birth control pills or HRT. It even says that estrogen therapy is known to cause dementia later in life...
    • haidut
    • Thread
    • anti-androgen treatment brain brain shrinking decrease dementia estrogen hormone replacement therapy study volume
    • Replies: 3
    • Forum: Scientific Studies
  19. raypeatclips

    Combined Chromium And Magnesium Decreases Insulin Resistance More Effectively Than Either Alone

    Can't seem to see what type of magnesium they used, as many forms of magnesium are horribly absorbed. I wonder if magnesium alone would have been good if it was a more absorbable type. Combined chromium and magnesium decreases insulin resistance more effectively than either alone. - Abstract -...
  20. haidut

    Taurine May Treat Depression And Psychosis In Humans

    A human study, and as such very relevant. The dose (4g daily for 12 weeks) was a bit on the high end but that was probably because the scientists designing the trial were unaware of the studies showing benefits of taurine plateau after 2g daily. In any event, good news for those with mood/mental...
    • haidut
    • Thread
    • cognition depression psychosis schizophrenia study taurine
    • Replies: 8
    • Forum: Scientific Studies
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