study

  1. haidut

    Pineal Gland Chemicals Inhibit Androgen Synthesis

    There is great interest in the blogosophere in writing about and supplementing with the pineal hormone melatonin. Ray has written about the dangers of melatonin, but there is enough contradictory research to confuse people. This study shows that another pineal hormone, which ALWAYS rises...
    • haidut
    • Thread
    • androgens hormone inhibition melatonin methoxytryptamine mtn pineal steroid study
    • Replies: 2
    • Forum: Scientific Studies
  2. Drareg

    R-Loop Formation Is A Distinctive Characteristic Of Unmethylated Human CpG Island Promoters

    This is interesting,to speculate as anger out as it may be it could be possible to create a supplement that encourages RLoops. SUMMARY CpG islands (CGIs) function as promoters for approximately 60% of human genes. Most of these elements remain protected from CpG methylation, a prevalent...
  3. Drareg

    Hypomethylation

    This where things get complex,hypomethylation is also a factor in aging and disease as much as hypermethylation. If this is correct it means you need a balancing act to get things right,certain drugs to target different areas. I curious if the interpretation is right,I don't currently have this...
  4. Drareg

    The Emerging Nexus Of Active DNA Demethylation And Mitochondrial Oxidative Metabolism In Post-Mitoti

    Are they implying ROS is helping demethylate or its oxidative metabolism,do they ignore co2 then? The variable patterns of DNA methylation in mammals have been linked to a number of physiological processes, including normal embryonic development and disease pathogenesis. Active removal of DNA...
  5. Drareg

    Interleukin 6 Supports The Maintenance Of P53 Tumor Suppressor Gene Promoter Methylation

    I think this study is implying hypermethylation of Dna by IL-6. Abstract A strong association exists between states of chronic inflammation and cancer, and it is believed that mediators of inflammation may be responsible for this phenomenon. Interleukin 6 (IL-6) is an inflammatory cytokine...
  6. DaveFoster

    Ancient Native Americans Drank Strong Coffee

    Ancient Americans Pounded ‘Black Drink’ 6 Times Stronger Than Coffee
  7. haidut

    Cancer Deaths In Females Will Rise By 60% In The Next Two Decades

    So much for winning the war on cancer. I already posted another link (again from CNN) that cancer is now the leading cause of death in USA, surpassing the previous top killer CVD. Women's cancer deaths expected to rise 60% by 2030 - CNN.com "...The number of women dying worldwide from cancer...
    • haidut
    • Thread
    • cancer death decade female skyrocket study two worldwide
    • Replies: 5
    • Forum: Scientific Studies
  8. haidut

    "Happiest" Countries Are Simply Gobbling Up Anti-depressants (SSRI)

    I have always been suspicious of the annual reports of happiest countries around the world. I have visited quite a few of them (traditionally in Europe) and my observations are anything but positive. Yes, the people in those countries did smile more than other ones that the annual UN report...
    • haidut
    • Thread
    • antidepressant countries happiness highest index scandinavian ssri study un whr
    • Replies: 91
    • Forum: Scientific Studies
  9. Drareg

    Lifetime Stress Accelerates Epigenetic Aging,relevance Of Glucocorticoid Signaling

    http://genomebiology.biomedcentral.com/articles/10.1186/s13059-015-0828-5 We examined the effect of lifetime stressors on a DNA methylation-based age predictor, epigenetic clock. After controlling for blood cell-type composition and lifestyle parameters, cumulative lifetime stress, but not...
  10. Drareg

    High Cortisol In 5-year-old Children Causes Loss Of DNA Methylation In SINE Retrotransposons: A

    Whats interesting here is it's showing cortisol demethylating dna? Lowering cortisol in certain circumstance might not be ideal? High cortisol in 5-year-old children causes loss of DNA methylation in SINE retrotransposons: a possible role for ZNF263 in stress-related diseases "Childhood stress...
  11. Drareg

    Human Aging-associated DNA Hypermethylation Occurs Preferentially At Bivalent Chromatin Domains

    Hypermethylation occurs at Bivalent chromatin domains. http://genome.cshlp.org/content/20/4/434.full.pdf
  12. Drareg

    Genome-wide Methylation Profiles Reveal Quantitative Views Of Human Aging Rates

    Another study on methylation death clock. http://www.sciencedirect.com/science/article/pii/S1097276512008933 The ability to measure human aging from molecular profiles has practical implications in many fields, including disease prevention and treatment, forensics, and extension of life...
  13. Drareg

    The Epigenetic Clock And Telomere Length Are Independently Associated With Chronological Age And Mor

    It seems methylation is now part of the biological clock theory according to below study. Background: Telomere length and DNA methylation have been proposed as biological clock measures that track chronological age. Whether they change in tandem, or contribute independently to the prediction of...
  14. Elie

    Study Concluded Replacing Dairy Fat With PUFA Calories Decreases CVD Incidence. Legit?

    Here is the abstract. Wonder if anyone has access to full text. I'd like to read the methodology. Dairy fat and risk of cardiovascular disease in 3 cohorts of US adults. - PubMed - NCBI Abstract BACKGROUND: Few prospective studies have examined dairy fat in relation to cardiovascular disease...
    • Elie
    • Thread
    • cvd dairy pufa study
    • Replies: 15
    • Forum: Diet
  15. haidut

    Demyelinating Conditions Like MS Can Be Treated By Androgens

    Ray wrote quite a bit on the topic of estrogen as a causative factor in demyelination and progesterone / pregnenolone as remyelinating agents. I posted an animal study recently on using DHT to completely reverse the pathology of the MS that model...
    • haidut
    • Thread
    • androgen receptor androgens dht multiple sclerosis physiological remyelination reversal study testosterone treatment
    • Replies: 6
    • Forum: Scientific Studies
  16. haidut

    DIM Is A Potent Androgen Antagonist And Estrogen Agonist

    The question of supplementing DIM often comes up on this forum despite Peat directly advising against it. Aside from its known anti-thyroid functions, we can now add a potent androgen antagonism to its list of "benefits". So, please stop loading up on DIM in the (false) hope that it somehow...
    • haidut
    • Thread
    • androgen antagonist dht dim estrogen agonist prostate receptor study
    • Replies: 38
    • Forum: Scientific Studies
  17. haidut

    Pregnenolone & Progesterone Are Both Agonists Of The Androgen Receptor

    Patients with prostate cancer are often treated with a combination of therapies such as 5-AR inhibitors to reduce production of DHT as well as other enzyme inhibitors to reduce conversion of DHEA into other downstream androgens. From the point of view of mainstream "treatment" for prostate...
    • haidut
    • Thread
    • androgen agonist androgenic growth nucleus pregnenolone progesterone prostate study translocation
    • Replies: 24
    • Forum: Scientific Studies
  18. P

    The Role Of Vitamin K In The Metabolism Of Connective Tissue Biopolymers

    [The role of vitamin K in the metabolism of connective tissue biopolymers (review)]. - PubMed - NCBI Metabolism of connective tissue biopolymers was studied under conditions of various content of vitamin K in the body. The data obtained suggest the existence of a new metabolic effect of...
  19. Drareg

    DMSO-induced Perturbation Of Thermotropic Properties Of Cholesterol-containing DPPC Liposomes

    Abstract Dimethyl sulfoxide (DMSO) is a universal solvent widely used in many fields, from basic research to industrial applications. At low concentration, it is the most important cryoprotectant agent against cellular damage caused during a freeze-thaw cycle. Although the effects of this...
  20. haidut

    Vitamin D3 Extends Lifespan By Preventing Toxic Protein Buildup

    Over the last 6-9 months I noticed that often people who communicate with Peat over email get a recommendation to supplement with vitamin D. When asked why, Peat said that he knows quite a few people who recovered from "very serious symptoms" by using vitamin D. Well, this new study shows that...
    • haidut
    • Thread
    • aging alzheimer's brain cholecalciferol condition extension homeostasis lifespan neurodegenerative parkinson's protein study vitamin d
    • Replies: 21
    • Forum: Scientific Studies
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