stress

  1. haidut

    Pregnenolone (P5) blocks stress-induced anxiety, hypertension and cocaine cravings

    A great new study, and with humans too! As the study aptly demonstrates, the primary driver of cocaine cravings is likely stress and the anxiety it causes. This finding is another corroboration of the findings of the great Rat Park experiment/study on "addiction". In the study below, the...
    • haidut
    • Thread
    • addiction anxiety cocaine cvd hypertension p5 pregnenolone stress
    • Replies: 16
    • Forum: Scientific Studies
  2. haidut

    Lowering adrenaline as effective as opioids for severe/chronic pain

    Most of my readers know about the raging opioid abuse epidemic in Western countries. What most people do not know is that the bulk of the epidemic is not in usage of illegal opioids such as fentanyl, but in legally prescribed opioids such as methadone, oxycontin, and even morphine. There are...
    • haidut
    • Thread
    • addiction adrenaline chronic clonidine opioid pain rat park stress
    • Replies: 7
    • Forum: Scientific Studies
  3. haidut

    Low testosterone (T) may drive kidney and liver disease (NAFLD) in men

    As many of my readers know, the "normal" range for T has been changed multiple times over the last several decades and each new iteration shifts both the lower and upper limit of the "normal" range downwards. In other words, a male with serum T in the 300 range would be considered "healthy" by...
    • haidut
    • Thread
    • ckd diet hypogonadism kidney liver nafld stress testosterone
    • Replies: 0
    • Forum: Scientific Studies
  4. I

    Hypersensitivity? Nerve problem after surgery and stress

    Sort of reposting a lingering problem for which we can’t find a solution. After a hair transplant end November 2021 and a period of high stress, I started to experience physical symptoms. The symptom/problem started around mid-December (3-4 weeks after surgery). Started with a burning sensation...
    • igemfourd
    • Thread
    • hypersensitivity nerve pain stress
    • Replies: 12
    • Forum: Metabolism
  5. LLight

    Relaxation/meditation and eyes defocus

    I don't know if you have ever experienced the eyes-defocusing that can happen when you close your eyes and relax or concentrate on your breath. I was able to do that pretty consistently when I was doing meditation like 3 years ago. Then, I tended to loose this "ability" along with the capacity...
  6. haidut

    Negative childhood experiences accelerate aging/disease in humans

    I am posting this study mostly as a counterexample to all the drivel coming out of gerontology research circles. Namely, the dogma is that biological aging is overwhelmingly influenced/determined by genes and cannot really be retarded (pun intended) or accelerated by the environment. This dogma...
    • haidut
    • Thread
    • abuse aging biomarker childhood disease neglect nurture stress
    • Replies: 5
    • Forum: Scientific Studies
  7. DDRB

    More calories destroy my sleep ?

    I'm quite thin (barely 70 kg for 1m82) but I notice that each time I increase my calories on purpose (to try to gain weight for example) my sleep problems seem to get worse. I have big problems with insomnia, but my best nights sleep is when I'm "undernourished", I actually even perform better...
  8. tastyfood

    How much do you pee per day?

    Serious question. Urine output is a good indicator for cortisol levels. It can be used to gauge the state of metabolism as well. I just took a 24 hour sample to Labcorp. The amount this time was 2.1L. I have struggled with large urine daily outputs for years. Frequent urination is really...
  9. haidut

    Stress (cortisol) makes even altruistic people selfish

    A great new study, which may explain a good deal of the general perception and several studies from the last decade claiming that societies in Western countries are becoming more selfish, combative/polarized, and even psychopathic. The more shocking finding of the study was that cortisol was...
    • haidut
    • Thread
    • altruism cortisol narcissism psychopathic selfish sociopathic stress
    • Replies: 4
    • Forum: Scientific Studies
  10. haidut

    "Reductive" stress harms cells, mitochondria protect by increasing metabolism

    Finally a study that provide me with some "ammo" during my arguments with people I know who work in the medical profession. A common topic in such arguments is the mainstream medical idea that it is almost impossible to have too much antioxidants and too little oxidation. In fact, to many...
    • haidut
    • Thread
    • metabolism mitochondria oxidation redox reduction stress sulfhydryl thiol
    • Replies: 24
    • Forum: Scientific Studies
  11. haidut

    Fasting causes aging by energy depletion, vitamin B2 can stop it

    Well, if this title does not rile up the fasting crowd, I don't know what will:-) Aside from that controversy, it is actually a great study that not only suggests a dirt cheap and widely available option for retarding aging, but once again demonstrates that stress (e.g. fasting) directly causes...
    • haidut
    • Thread
    • aging ampk fad fasting oxphos riboflavin senescence senolytic stress vitamin b2
    • Replies: 47
    • Forum: Scientific Studies
  12. haidut

    Fasting / stress decimate gonadal steroidogenesis, with no effect on blood cortisol

    A very interesting and very "controversial" (read: inconvenient truth) study, since it shows beyond reasonable doubt that even brief (4 days) fasting is a form of severe stress, at least when it comes to endocrine health. The study may also provide answers to various endocrine "mysteries"...
    • haidut
    • Thread
    • androgen atrophy cortisol fasting gonads hypogonadism stress
    • Replies: 15
    • Forum: Scientific Studies
  13. tastyfood

    Struggling with high ACTH results, am I taking supplements too late in the day?

    I had the highest result of ACTH this week, with 99.1 pg/mL, at 8 in the morning. The reference range for tests in the AM is 7.2-63.3 pg/mL. One of the things I'm evaluating is my consumption of supplements and thyroid towards bed time. Could it be that taking stimulating things before bed...
  14. haidut

    Scoliosis (even in females) may be driven by low androgen levels, DHT may treat it

    I am posting about this condition as it seems recently its numbers have absolutely exploded in the general population. Scoliosis used to be a relatively uncommon condition, usually present in adults over the age of 50. Mainstream medicine has no explanation for its possible causes, but suspects...
  15. JamesGatz

    Do we really need 7-8 hours of sleep ? Does low stress/faster metabolism lower the time our body's require to rest ?

    I noticed that when my health was bad or when I had a stressful job I could sleep 10 hours a day probably - I know that if I had a long day at work and only got 6 hours of sleep I would wake up very tired and with adrenaline pumping - did not feel well rested at all - I would get so tired from...
  16. pauljacob

    Nerves Shot Because of Emotional Stress

    I'm currently under emotional stress from three directions: my demented brother, my estranged wife, and my inability to make headway in my work. Three weeks ago, I became bloated and gassy, acid rising to my throat during sleep. The gastroenterologist recommended an endoscopy but I declined...
    • pauljacob
    • Thread
    • bloating chromoendoscopy emotional stress gastroesophageal reflux disease gerd not eating stomach gas stress throwing up
    • Replies: 6
    • Forum: Digestion
  17. JamesGatz

    Can a fruit sense when you are about to kill him/cut him open ? Do they release a stress response if they see you coming for the kill ?

    I remember coming across a study on this forum (I believe it was a Russian experiment) where a researcher took a pineapple and cut it open in front of another pineapple - The pineapple that was alive to "Watch" the encounter released an electrical response when the person that killed the...
  18. JamesGatz

    Can earplugs or sound-resistant rooms have a positive effect on metabolism in certain environments ? Examining the cortisol increase for loud noises

    I notice that since Peating - I notice "stressors" a lot more - I cannot stand being around a construction site - hearing the sound of a jackhammer or a drill sends me to disarray or someone hammering really stresses me out I also notice that if I'm in a party-like environment - where the...
  19. haidut

    Vitamin D3 anabolic, calcitriol catabolic for muscle/thymus

    Several great studies, which will probably do little to calm down the controversy that seems to be brewing lately in the blogosphere over whether supplementing with vitamin D3 is beneficial or not. Namely, the last study below demonstrated direct muscle-anabolic effects from supplementation with...
    • haidut
    • Thread
    • anabolic anticatabolic calcitriol cholecalciferol cortisol muscle stress thymus vitamin d3
    • Replies: 4
    • Forum: Scientific Studies
  20. JamesGatz

    The feeling of being watched - what about the feeling of being recorded ? Do celebs hate paparazzi because of EMF ?

    I am sure most of us are familiar with the phenomenon of "feeling like you are being watched" - I have experienced something even more interesting - when someone is recording me with their phone camera or a DSLR especially - I can immediately sense it even if I am not facing that direction - I...
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