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sert

  1. haidut

    High (extracellular) serotonin causes Alzheimer's and depression

    The utter corruption of "journalism" is once again on full display in MSM. The actual scientific study is very clear in its statements/conclusions that a decrease in the levels of serotonin transporter (5-HTT) led to accumulation of beta-amyloid and onset of depression. Lower levels of 5-HTT -...
  2. P

    Progesterone receptors and serotonin levels in colon epithelial cells from females with slow transit constipation (P4 lowers SERT)

    Abstract link to study Background: Females with slow transit constipation (STC) exhibit progesterone receptor (P4R) overexpression in colon muscle that impair their contractility. These studies examined whether these patients have an overexpression of P4R in epithelial cells and...
  3. haidut

    Serotonin (and SSRI drugs) can cause anxiety and PTSD

    Yet another great study exposing just how much of a "happy hormone" serotonin really is. As usual, the popular press article does everything possible to avoid pointing the finger at serotonin and even engages in misdirection. For example, it says that SERT is the main target of drugs like...
  4. haidut

    PUFA And Serotonin Promote Each Other, And Likely Cause Mental Illness

    I neat new study that draws a direct parallel between PUFA-driven inflammation, serotonin and depression. As the study demonstrated, high levels of the PUFA arachidonic acid (AA) are highly correlated with lower density (expression) of the serotonin transported (SERT, 5-HTT), and the...
  5. haidut

    Serotonin Excess, Not Dopamine Deficiency, May Be The Cause Of Parkinson

    One of the most paradigm-challenging studies I have seen this year and, unsurprisingly, mainstream media is pulling all sorts of tricks to avoid naming the culprit directly. Even the press release and the study abstract are worded in a convoluted way, talking about a "serotonin dysfunction"...
  6. haidut

    Elevated Serotonin Increases Criminal Activity

    The study looked at correlations between ambient temperature and criminal activity and found that higher temperatures correlate with reduced SERT density and as such elevated serotonin. The SERT protein is the one that deactivates serotonin and it is a sodium dependent protein. Serotonin...
  7. L

    Androgens Increases SERT, Estrogens Decreases It

    SERT aka serotonin reuptake transporter reduces serotonin levels. This study show that testosterone increases SERT levels whiles estradiol & anti-androgen decreases it. High-Dose Testosterone Treatment Increases Serotonin Transporter Binding in Transgender People. - PubMed - NCBI ...SERT...
  8. haidut

    Serotonin/endotoxin/PUFA As Primary Causes Of Depression And Diabetes; Can Be Easily Blocked

    This is one of the unique studies that breaks away from the mainstream dogma that serotonin is the "happy hormone" and increasing it with drugs like SSRI can lead to nothing but goodness. The study not only directly states that past/current SSRI use is a risk for developing diabetes but show how...
  9. haidut

    Tremor In Parkinson Disease (PD) Is Due To High Serotonin

    The non-motor signs/symptoms of PD (tremor, drooling, slurred speech, etc) have long been thought to be directly due to dopamine deficiency due to the death of the nigrostriatal dopamine neurons. The common treatment for those signs/symptoms and the motor symptoms as well is usually a dopamine...
  10. haidut

    Colon Aging / Cancer? Due To Low NAD / High Serotonin; Niacinamide Reverses Both

    Peat has said many times that the impaired bowel regularity that occurs in aging, hypothyroidism and various pathologies is due to high NO and serotonin. He also said that while serotonin inhibits motility in the colon it increases it in the small intestine. Most doctors do not agree with that...
  11. allblues

    Serotonin Transporter Deficiency Drives Estrogen-dependent Obesity And Glucose Intolerance

    This 2017 study here is making me scratch my head. Serotonin transporter deficiency drives estrogen-dependent obesity and glucose intolerance So these people genetically deleted the serotonin transporter in a group of mice, and pharmacologically antagonized it with an SSRI in another group of...
  12. haidut

    Higher Serotonin Availability May Be The Cause Of Cognitive Impairment / Dementia

    Some of you may have seen this study in the news lately. However, it is being presented as the exact opposite as what my title says. The media titles all over the Internet proclaim that "John Hopkins study shows low serotonin causes dementia". However, if you look at the actual study you will...
  13. haidut

    Poverty Causes Depression By Increasing Serotonin Activity

    The conditions of learned helplessness and PTSD have many features in common and both of them have been linked to dysfunction of the monoaminergic system. There has been a lot of research over the last decade tying adverse life conditions in childhood to mood and memory problems as an adult...
  14. haidut

    Zinc Acts Similar To Tianeptine And Blocks SSRI Drug Effects

    Basically, the study says that zinc increases serotonin uptake, making it a "SERT" drug acting in a manner opposite to SSRI drugs. The study even compared zinc effects to some well-known SSRI drugs. I thought that was pretty cool, and a possible alternative for people with no access to...
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