senescence

  1. haidut

    Increasing serotonin (5-HT) breakdown delays/prevents aging

    The naked mole rat (NMR) is one of the most fascinating species. Despite being a humble rodent, much smaller than a regular house/city rat, the NMR has an exceptionally long life-span of 35+ years (compared to 2-3 years for the common rat) and on top of that is remarkably resistant to the...
    • haidut
    • Thread
    • 5-ht aging inflammation lifespan senescence senolysis serotonin
    • Replies: 20
    • Forum: Scientific Studies
  2. TruffleGnocchi

    Video with visuals: Taurine - a supplement for longevity? -- The Sheekey Science Show

    Here is a video on youtube by The Sheeky Science Show. Going over some results of some studies, showing graphs and other data, explaining potential benefits and some mechanisms. Taurine - a supplement for longevity Some timestamps and extracts from the video: 1:02 taurine...
    • TruffleGnocchi
    • Thread
    • bone density cytotoxicity gaba longevity mitochondria protein folding senescence taurine tudca white blood cells
    • Replies: 3
    • Forum: Taurine
  3. haidut

    Major depression likely driven by mitochondrial deterioration/dysfunction

    This the latest study demonstrating that not only are various chronic diseases and aging essentially the same process, but that this process is fundamentally bioenergetic in nature. Namely, dysfunctional mitochondria, leading to low OXPHOS, is the direct cause of many physiological and "mental"...
    • haidut
    • Thread
    • aging bioenergetics depression gdf-15 mitochondria oxphos senescence senolytic
    • Replies: 4
    • Forum: Scientific Studies
  4. haidut

    Fasting causes aging by energy depletion, vitamin B2 can stop it

    Well, if this title does not rile up the fasting crowd, I don't know what will:-) Aside from that controversy, it is actually a great study that not only suggests a dirt cheap and widely available option for retarding aging, but once again demonstrates that stress (e.g. fasting) directly causes...
    • haidut
    • Thread
    • aging ampk fad fasting oxphos riboflavin senescence senolytic stress vitamin b2
    • Replies: 47
    • Forum: Scientific Studies
  5. haidut

    DHT can stop aging of the pancreatic beta-cells (insulin-producing)

    Another great study, which demonstrates that far from being a "villain" (in both males and females) DHT is in fact a crucial and positive factor in health. In this specific study below, it was demonstrated that DHT dose-dependently inhibited the aging/dysfunction of the pancreatic beta-cells...
    • haidut
    • Thread
    • aging androgen beta-cells dht diabetes insulin pancreas senescence
    • Replies: 0
    • Forum: Scientific Studies
  6. Hans

    High dose anti-oxidants can cause premature cellular senescence

    https://pubmed.ncbi.nlm.nih.gov/34769282/ "In our previous study, we found that high doses of several substances with antioxidant capacities (Tempol, resveratrol, diphenyleneiodonium) can cause genotoxic stress and induce premature senescence in the human mesenchymal stem cells (MSCs). Here...
  7. haidut

    Striking Accumulation Of PUFA In Aged Cells

    Peat has written many times about the changes that occur in "aged" cells. Those changes are virtually indistinguishable from the ones that occur in "sick" cells and are characterized by reduced mitochondrial number/size and a shift in lipid composition away from saturated and towards unsaturated...
    • haidut
    • Thread
    • accumulation age aging cell cellular old pufa senescence
    • Replies: 10
    • Forum: Scientific Studies
  8. L

    Antibiotics Eliminate Senescent Cells Associated With Ageing

    https://medicalxpress.com/news/2018-11-antibiotics-senescent-cells-ageing.html?fbclid=IwAR1m93y_0tkxmuNBygM8V9horgk3C9USptUnaWs8Vn_8ysaG8MXKcl1ZWEI what n intriguing paper. STandard doses shoould be sufficient to achieve senolytic blood-levels. I've also seen this one that paves a simlar...
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