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One of the key features of aging is the decline in mitochondrial function (metabolism), and that fact is widely recognized even by mainstream medicine. However, doctors still claim that the relationship between metabolic decline and aging has not be elucidated and a causative link cannot be...

Just a few weeks ago I made a post about yet another study linking grey hair to increased stress. The mechanism of action described in that study was increased HPA activity and specifically elevated norepinephrine levels. Other studies have also implicated tryptophan/serotonin, which is still...

A great new study, which once again confirms the importance of metabolism in "aging" disorders such as infertility (both female and male) and menopause. More specifically, it was the increase in NAD/NADH ratio that was the main mechanism of action behind the beneficial effects of nicotinamide...

As many of my readers know, currently there is an epidemic of the condition known as non-alcoholic fatty liver disease (NAFLD). By some estimates, more than 30% (100mil) of people living in the US have NAFLD and in about 25% of those the condition will progress to the more severe form known as...

A great series of studies performed in the 1960s, with Hans Selye spearheading most of the investigations. It is amazing how much was known about human disease and aging, and how much of that knowledge has been so thoroughly forgotten to the point that doctors nowadays have never even heard of...

As it seems, not all hope is lost when it comes to mainstream medicine. Just a few days ago I posted about a landmark human study with AD demonstrating that the a low daily dose of the cheap, unpatentable chemical methylene blue (MB) may stop AD. LSD may do the same, and both MB and LSD likely...

Yet another study demonstrating the remarkable parallels between the decline in function (metabolism) and the structural abnormalities that occur not only in specific pathologies such as AD but also in the generalized degradation known as "aging". FDA currently does not recognize aging as a...

Another great result for the humble dye whose only claim medical fame so far has been as treatment for malaria, and even that "designation" has largely been deprecated due to the advent of new and "improved" drugs. About a decade ago, a company in the UK started researching MB as potential...

If there is any disease that is currently considered incurable even in principles, it likely comes from the group of inherited/genetic disorders. Perhaps the most well-known one, due to rapidly rising incidence and thus publicity, is DS. Perhaps its most disabling aspect of DS is the cognitive...

As many of my readers already know, there are a number of human studies, going back to at least the 1960s, demonstrating that supplementation with saturated fats (SFA) protects the liver from damage induced by alcohol. I fact, supplementation with SFA not only prevents alcohol-induced liver...

This is a human study, so the findings are that much more relevant even though they probably do not come as a surprise to users of this forum. The duration of the study was just 6 weeks and the dose was 500mg nicotinamide riboside (NR) twice a day (for a total of 1,000mg). There were no side...

As many of you know arterial stiffness is one of the main signs of CVD and contributes significantly to both elevations of blood pressure (BP) and actual ischemic events in brain/heart. According to official guidelines, arterial stiffness cannot be reversed once it sets in, and the only recourse...

This study is yet another one that shows benefit of raising NAD levels for treating neurodegenerative conditions like AD. There were a few older studies around 2003, which were also done on mice and as a result of those studies a human clinical trial with 3g niacinamide daily (a dose that...

I am posting this study as a response to the attacks I keep getting over email and PM, claiming that there absolutely no evidence for my statements that progesterone has androgenic effects (depending on the dose). As I mentioned in many other threads, progesterone is actually a true ligand for...

First, please note that this study is about nitrous oxide (N2O) and not nitric oxide (NO). There is a huge difference in effects despite the minor difference in chemical structure. Peat has written about both - the benefits of the former and the dangers of the latter. N2O is commonly known as...

The so-called fetal alcohol syndrome has been on the rise over the last 2 decades and its symptoms largely overlap with the "adult" alcohol syndrome or at least the behavioral parts of it. Broda Barnes once wrote that he never treated an alcoholic who was not also hypothyroid and that he also...

Meet your new beauty ingredient - ketotifen. UV light exposure is one of the main triggers of visible signs of skin aging and contributes to lipofuscin formation as well. It looks like ketotifen may be able to prevent that damage and given its leukotriene and histamine antagonism it may be a...

In a recent interview Peat explained the connection between endotoxin, hypothyroidism, and rheumatoid arthritis. I recently posted a study claiming that chronic activation of the endotoxin receptor TLR4 synergizes greatly with iron and is probably a causative factor in many degenerative...

I posted a few threads on vitamin D and how it may help treat endotoxin-related condition, especially ones affecting the liver. Vitamin D Is Endotoxin (LPS / TLR4) Antagonist, May Treat LPS-linked Conditions Endotoxin is perhaps the primary driver of actual liver fibrosis, which (if left...

Over the last few years there have been a number of studies linking SSRI use with increased risk of fracture. Subsequent studies found this link to be definitively causal - i.e. SSRI drugs cause those fractures. However, the mechanism of action was officially ascribed to the medical...