1. Hans

    The Unexpected Downsides of Resveratrol as an Aromatase Inhibitor
  2. haidut

    Pregnenolone Is An Estrogen Antagonist

    This has been stated by Peat a few times but usually the assumption has been that pregnenolone converts into progesterone and that is how it exerts its anti-estrogenic effects. This older study claims that pregnenolone (also called delta-5-pregnenolone) is directly antagonistic to estrogen...
  3. haidut

    Resveratrol Apparently Is Not The Answer To The French "paradox"

    Yet another study, which shows that whatever the longevity benefits of wine and berries are, they are not due to resveratrol. Just thinking how many hundreds of millions went into "researching" and promoting this substance is just mind boggling.
  4. haidut

    Resveratrol Stimulates Cortisol Synthesis

    Yet another reason to avoid resveratrol. The mechanism of action is suppression of cytochrome P450, which is known as the "master detox" enzyme. I wonder if other estrogenic substances, including estrogen itself stimulate cortisol synthesis through the same mechanism. If yes, substances that...
  5. haidut

    The Resveratrol Scam Is (finally) Unfolding

    Resveratrol is a potent phytoestrogen and its purported "longevity" action through SIRT-1 is antagonized by niacinamide. This study actually did blood testing and lasted for 11 years, so I am inclined to give it more weight. If one even needs a study to debunk the "benefits" of a phytoestrogen...