1. haidut

    Adolescent stress causes mental illness, cognitive issues by lowering metabolism

    It has long been known that pre-natal stress (e.g. stressed of the mother during pregnancy), as well as chronic stress after birth are associated with high risk of mental illness, criminal behavior, substance abuse, reduced cognitive function, chronic illness, and even early death. However, the...
  2. haidut

    Aging Likely Caused By Decreased Respiration / Metabolism, Not Genetic Mutations

    It looks like after a century of utter idiotism in biology and medicine, those two disciplines may finally be getting on the right course. Despite the fact that the "rate of living" theory is still the dominant theory of aging in the halls of academia, a new generation of scientists is emerging...
  3. haidut

    Stearic Acid Increases Mitochondrial Function, May Treat Parkinson Disease (PD)

    I posted recently about the ability of dietary stearic acid to reduce abdominal fat accumulation by more than 70%. This study provides some insight as to what the mechanism of action behind that anti-obesity effect may be. The study below found that when stearic acid was fed at a dose of 10% of...
  4. haidut

    Inosine Powerfully Stimulates Mitochondriogenesis, Oxidative Metabolism & Cell Differentiation

    Yet another absolutely great study on inosine. It shows that not only can inosine replenish ATP (as shown in the previous studies I posted) but it can inhibit excessive glycolysis, lower lactate, and dramatically improve oxidative metabolism - effects which are key driver of cell differentiation...
  5. haidut

    Acetaminophen (Tylenol) Decreases Respiration By Changing Cardiolipin Composition

    I posted a few threads recently on the negative effects of acetaminophen (Tylenol) on brain function and steroid response. Acetaminophen (Tylenol) Exposure During Pregnancy Feminizes The Offspring Acetaminophen raises serotonin/adrenaline, aspirin lowers it User @Koveras also posted a thread...
  6. haidut

    Palmitic Acid (palmitate) Strongly Increases Oxidative Metabolism

    This is yet another thread as a follow up on the recent posts about plamitic acid inhibiting fatty acid oxidation and having therapeutic roles in cancer, diabetes and all other disease characterized by elevated/abnormal fatty acid metabolism. Palmitic Acid (palmitate) Is A Fatty Acid Oxidation...
  7. haidut

    Optimal Dose Of Niacinamide For Stimulating Respiration

    As many of you know, the Wikipedia page has a warning not to take more than 3g daily as it may elevate liver enzymes. I traced the warning to a few studies with high dose niacinamide using 4g - 6g daily for conditions like HIV and arthritis. However, they did not provide an explanation on why...
  8. haidut

    Lapodin - Liquid Emodin/β-lapachone Mix

    Peat has written many articles on the topic of quinones and their effects on metabolism / respiration. The earliest official work probably started around the time of William Koch in the early 20th century and continues to this day. Many people are familiar with the popular quinone CoQ10 but...
  9. haidut

    DMSO, Even At Very Low Doses, Increases Respiration In Brain

    I am posting about DMSO b/c we are considering changing some of solvents in the supplements from oil to DMSO + ethanol. While researching DMSO toxicity, I stumbled upon study showing that DMSO stimulates respiration in the brain in practically all doses (including very low ones)...
  10. haidut

    Organ Extracts Stimulate Respiration Like Methylene Blue (MB)

    In support of Ray's views of using organ extracts for therapeutic purposes. This study is from the 1930 and at the time they probably did not know about the existence of the thyroid hormone. What the study does is state that most organs, but especially liver and kidney, contained a "respiration...
  11. haidut

    The effects of methylene blue (MB) on tumor respiration

    The effects of MB on respiration of normal cells and tumors appears to be quite different. According to this study, the positive effects of MB on respiration depend on the degree to which the tissue has become deranged in the direction of a tumor. The more tumor-like the metabolism of the...
  12. haidut

    Methylene Blue (MB) Uncouples Respiration

    This was an in-vitro study, but knowing the effects of MB in vivo makes it very plausible that MB is indeed a respiration uncoupler similar to DNP. ... 9397007679 "...In tightly coupled, succinate-respiring mitochondria, addition of MB resulted in an...
  13. P

    caffeine can reduce respiratory quotient

    maybe if not taken with lot of carbs/sugar
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