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  1. cs3000

    High Acetylcholine = learned helplessness, depression - What are good ways to lower acetylcholine or increase acetylcholinesterase activity?

    Ray peat has spoken about the negatives of acetylcholine relating to stress and learning Acetylcholine is an excitotoxic neurotransmitter Acetylcholine likely raises serotonin in the brain (preferentially inhibits MAO-A in the brain) https://pubmed.ncbi.nlm.nih.gov/19025057/ AChE inhibitors...
    • cs3000
    • Thread
    • acetylcholine acetylcholinesterase depression inhibit learned helplessness lower acetylcholine reduce
    • Replies: 13
    • Forum: Ask For Help or Advice
  2. haidut

    Aspirin Has Dramatically Lower Bleeding Risk Than Pharma Anticoagulants

    Just a quick post that adds to the mountain of evidence contradicting the fearmongering about aspirin we hear on a daily basis from every doctor who manages to get some TV time. It has been known for a while that aspirin lowers bleeding risk in brain and GI tract, despite being an anti-coagulant...
  3. haidut

    DHT Is Negatively Associated With Death From Prostate Cancer

    Just a quick study that, despite being epidemiological, raises serious questions about the validity of the "androgen-driven" hypothesis of prostate cancer. If the assumption is that DHT is the primary driver of prostate cancer it is hard to come up with any plausible explanation of how the...
    • haidut
    • Thread
    • androgen dht dihydrotestosterone lethality mortality prostate cancer reduce
    • Replies: 4
    • Forum: Scientific Studies
  4. haidut

    Reducing Stress May Reverse Greying Of Hair

    Just a few weeks ago I made a post about yet another study linking grey hair to increased stress. The mechanism of action described in that study was increased HPA activity and specifically elevated norepinephrine levels. Other studies have also implicated tryptophan/serotonin, which is still...
  5. haidut

    Vitamin K May Help Reduce Arterial Stiffness & Improve Blood Pressure

    For those of my readers who don't know, vitamin K is a prescription drug in many countries for treating/preventing osteoporosis, blood pressure, liver disease, neurological disorders, cancer, etc. Japan is where this remarkable substance enjoys perhaps the most prestige as an actual drug for...
    • haidut
    • Thread
    • arterial stiffness calcification cvd hypertension menaquinone menatetrenone mk-4 prevent reduce treat vitamin k
    • Replies: 9
    • Forum: Scientific Studies
  6. haidut

    Aspirin May Treat Brain Aneurysms

    Another huge win for aspirin, not only because of the condition's lethality, but because there is currently no treatment for it. While the study did not last long enough to make such claims, given the potent inhibitory effect on aneurysm growth I would not be surprised if aspirin actually makes...
    • haidut
    • Thread
    • aneurysm aspirin brain growth inhibit intracranial prevent reduce rupture slow treat
    • Replies: 1
    • Forum: Scientific Studies
  7. haidut

    Blue Light Accelerates Aging And Reduces Lifespan By More Than 50%

    In one of his interviews, Peat mentioned that red light exposure may be the most fundamental protective factor in nature, and that a deficiency of it (as commonly seen in Western lifestyles) may be the main driver of systemic aging and the diseases associated with it. The study below provides...
    • haidut
    • Thread
    • aging blue light exposure lifespan light metabolism mitochondria neurodegeneration reduce shorten stress
    • Replies: 13
    • Forum: Scientific Studies
  8. haidut

    Aspirin Actually Decreases Risk Of Bleeding In The Brain

    As many readers know, one of the scary stories Big Pharma tells about aspirin is that it increases the risk of bleeding in the GI tract or brain. As such aspirin has long been bashed as a possible cause of so-called hemorrhaging strokes. I posted studies a few years ago demonstrating that...
    • haidut
    • Thread
    • anticlotting aspirin beneficial bleeding blood-thinner hemorrhaging intracranial reduce risk stroke
    • Replies: 6
    • Forum: Scientific Studies
  9. haidut

    Daily Aspirin Reduces By 37% Risk Of Fatty Liver Progressing Into Cirrhosis

    Another great study about aspirin. What I particularly like about this study is that one of the authors is calling aspirin "a promising anti-fibrotic strategy for NAFLD". This is the first time I have heard a doctor refer to aspirin as anti-fibrotic chemical. Peat mentioned aspirin as one of the...
    • haidut
    • Thread
    • aspirin cirrhosis fatty liver fibrosis liver nafld prevent reduce risk
    • Replies: 5
    • Forum: Scientific Studies
  10. haidut

    Vitamin E Reduces Risks Of Cataracts By More Than 50%

    Quite a few people have been asking on the forum and via email about interventions for age-related cataracts. Here are some links below. The type of vitamin E used in all studies was alpha-tocopherol and the dose varied from 12mg/day all the way up to HED of 15mg/kg daily for the rodent model...
    • haidut
    • Thread
    • aging alpha-tocopherol cataracts cloudification humans long term long-term use prevent reduce tocopherol treat vitamin e
    • Replies: 4
    • Forum: Scientific Studies
  11. haidut

    Vitamin E Lowers Mortality, Transplantation Need In Liver Disease Patients

    Good study on the protective effects of vitamin E on progression of the liver disease known as NASH, which usually leads to cirrhosis and eventually a need for liver transplant. It is nice to see Big Pharma opening up to treatment with vitamins, but it is probably due to the failure of their...
    • haidut
    • Thread
    • cirrhosis fatty liver liver disease lower mortality nash reduce tocopherol transplantation vitamin e
    • Replies: 1
    • Forum: Scientific Studies
  12. haidut

    Aspirin May Prevent / Reduce HIV Infection In Humans

    A few years ago, I posted some studies showing that endotoxin is key in the development of AIDS. Those studies also found that without endotoxin, the HIV poses little risk to (healthy) organisms...
    • haidut
    • Thread
    • aids aspirin endotoxin hiv inflammation low-dose prevent prevention reduce systemic
    • Replies: 6
    • Forum: Scientific Studies
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