receptor

  1. haidut

    Fasting ups estrogen & cortisol, decimates vitamin D, may cause diabetes

    A really interesting study, which will likely generate more than a few hateful emails for my Inbox :): Anyways, as the study demonstrates, fasting achieves these negative effects due to the elevated fatty acids working through PPAR activator PGC-1α, to activate both the estrogen receptor (ER)...
  2. haidut

    PUFA And Endotoxin (LPS) Inhibit Vitamin D And Thyroid Transport / Activity

    The "good" news for PUFA and endotoxin just keep on coming. I already posted a few studied showing that PUFA inhibits binding of androgens to their receptor and increases binding of estrogens to their receptor. This new study shows that PUFA and endotoxin inhibit the binding of vitamin D to...
  3. haidut

    Cortisol And Aldosterone Cause Vascular Calcification

    In one of his newsletter circa 2015, Ray wrote about the role of aldosterone in heart failure, heart attacks, shock, and edema. He conjectured that aldosterone antagonists would one day be recognized as therapeutic for these conditions. Almost all types of heart disease start with vascular...
  4. haidut

    Exercise + Fasting Is Stress, Causes Obesity And IR, And Requires Cortisol Blockade To Reverse

    I think this thread will ring true for all people who at some in their lives exercised in order to lose weight. Just like fasting, it works great in younger age (<30) but it really masks a bigger metabolic problem and of course badly backfired in the long run. Exercise is a forced/stressed...
  5. haidut

    Structural Requirements For An Optimal Anti-Catabolic Steroid

    This post will be a bit long, but I hope it is worth it. I think @Jsaute21 and @dand will find it highly interesting but the information here applies just as much to females wishing to preserve lean tissue and prevent the catabolism that often occurs with aging. Here we go. Lately, I have been...
  6. haidut

    Omega-3 (DHA, EPA) Degrades The Androgen Receptor

    One of the reasons the medical industry continues to promotes the use of fish oils is that in animal studies it was shown to shrink the prostate. The mechanism was never fully elucidated, but I suspected it is probably not a good one. This study shows that omega-3 fatty acids are anti-androgenic...
  7. haidut

    Strong Androgens (DHT) As Treatment For CVD, Obesity And Metabolic Syndrome

    The study used DHT as the active drug but since the positive effects were due to androgen receptor agonism, any other strong androgen agonist should do. I think the lack of estrogenicity also contributed to the benefits of DHT observed in this study, so this would explain the mixed results with...
  8. haidut

    The Anti-cortisol Mechanism Of Progesterone

    I just posted the thread on the anti-cortisol mechanism of pregnenolone. The Anti-cortisol Mechanism Of Pregnenolone As I mentioned in that thread, the Peat has been saying that both pregnenolone and progsterone have anti-cortisol effects, however people have been questioning those statements...
  9. haidut

    The Anti-cortisol Mechanism Of Pregnenolone

    One of the recurring arguments on this forum is whether pregnenolone and progesterone (being technically precursor to the glucocorticoids) raise or lower cortisol levels, and whether they have effects opposing or promoting those of the glucocorticoids. The argument advanced by a few people here...
  10. haidut

    5α-Dihydroprogesterone (5α-DHP) Is More Effective Than Progesterone As Estrogen Antagonist

    The study below showed that the steroid 5α-Dihydroprogesterone (5α-DHP) is more effective that progesterone in decreasing the levels of estrogen receptor and can deliver the same result at quite low doses. The HED for 5α-DHP to achieve 75% inhibition of estrogen receptor levels were just...
  11. haidut

    DIM Is A Potent Androgen Antagonist And Estrogen Agonist

    The question of supplementing DIM often comes up on this forum despite Peat directly advising against it. Aside from its known anti-thyroid functions, we can now add a potent androgen antagonism to its list of "benefits". So, please stop loading up on DIM in the (false) hope that it somehow...
  12. haidut

    Pregnenolone Activates The Glycine Receptor

    This mechanism of pregnenolone is one of the proposed methods through which it enhances neurogenesis, memory, mood and even motor function. Low doses pregnenolon improve sleep quality and are even mildly sedating, which may also be due to the activation of the glycine receptor. Subunit-specific...
  13. K

    Cross Talk Between Progesterone And Estrogen Receptors In Breast Cancer

    I've never posted on the forum before but I've read many posts with great interest and want to say thanks to everybody for sharing helpful information. I'm wondering if some of you can confirm what is being stated by a study I was looking at pertaining to both progesterone and estrogen relevant...
  14. haidut

    Serotonin Antagonists As Therapy For Alzheimer Disease

    As I posted in another thread, over 90% of the drugs tested for Alzheimer during the last 10 years have veen utter and abject failure. This is a pretty solid indication that the theory of Alzheimer's pathology and proposed beneficial pathways on which these drugs were based is solidly wrong...
  15. haidut

    DHT Is Estrogen "receptor" Antagonist

    I have posted studies on DHT inhibiting aromatase and increaseing estrogen conjugation and excretion by the liver. However, this study shows that DHT is actually capable of direct anti-estrogen activity by binding to and antagonizing the estrogen "receptor" similarly to progesterone and vitamin...
  16. haidut

    Niacinamide Is Androgenic And Increases Dht Effects/signaling

    I just posted a study showing that inhibition of SIRT1 is anti-estrogenic, and SIRT1 inhibitors like niacinamide have similar effects to the estrogen receptor antagonist fulvestrant. Niacinamide Is Anti-estrogenic | Ray Peat Forum This study shows that, again through inhibition of SIRT1...
  17. haidut

    Caffeine Effect On Various "receptors"

    This study gives some indication as to what the chronic effects of caffeine ingestion are in terms of various "receptors" as defined by mainstream medicine. I attached a screenshot from the study, which summarizes the effects nicely. It's probably not a surprise that caffeine is an adenosine...
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