progesterone

  1. haidut

    Gonadin - Liquid Steroid Optimizer For Lab/R&D

    EDIT (11/1/2021): New version of Gonadin (called it Gonadin+ on one recent podcast with Danny Roddy, but I decided to keep the name as just Gonadin) has been released on November 1, 2021. The description of the ingredients that have been removed, and the studies about them, can be found in the...
    • haidut
    • Thread
    • anti-inflammatory anti-teratogenic antibiotic-chemotherapeutic anticonvulsant antidepressant antidiabetic antimicrobial antimutagenic antioxidant antitumorous anxiolytic aromatase inhibition gonadin lipid lowering phytol progesterone squalene steroid synthesis testosterone
    • Replies: 991
    • Forum: IdeaLabs
  2. BigYellowLemon

    Effects Of Morphine Dependence And Withdrawal On Levels Of Neurosteroids In Rat Brain

    Effects of morphine dependence and withdrawal on levels of neurosteroids in rat brain. - PubMed - NCBI It's a rat study but I think the results are applicable to humans. "The chronic morphine administration (ip) resulted in a marked decrease in the brain concentrations of pregnenolone (PREG)...
    • BigYellowLemon
    • Thread
    • allopregnanolone dhea dhea-s morphine naloxone naltrexone neurosteroid opioids pregnenolone progesterone steroids
    • Replies: 5
    • Forum: Scientific Studies
  3. Dan W

    KMUD: 1-20-17 The Precautionary Principle (Part 1)

    Direct MP3 link | Podcast setup This one was a mix of higher-level discussion with specific caller questions. The additional topics include: high doses of progesterone and thyroid, male pattern baldness, herniated discs, routine colonoscopies, and skin pigment. It cuts off a bit abruptly at...
  4. haidut

    Pregnenolone, Progesterone And DHEA Drop, Cortisol Rises In Aging

    I posted a few times about the steroidal characteristics of aging. Many people think there is a drop in testosterone (T) in aging and that is what drives the frailty of aging both in men and women. However, numerous studies show that that total T does not decrease with aging. What does seem to...
    • haidut
    • Thread
    • adrenals aging cortisol dhea dht estradiol gonads pregnenolone progesterone steroidogenesis steroids testosterone
    • Replies: 29
    • Forum: Scientific Studies
  5. haidut

    The Anti-cortisol Mechanism Of Progesterone

    I just posted the thread on the anti-cortisol mechanism of pregnenolone. The Anti-cortisol Mechanism Of Pregnenolone As I mentioned in that thread, the Peat has been saying that both pregnenolone and progsterone have anti-cortisol effects, however people have been questioning those statements...
    • haidut
    • Thread
    • acceleration antagonist binding cortisol dissociation glucocorticoid progesterone receptor
    • Replies: 26
    • Forum: Scientific Studies
  6. allblues

    Niacinamide And Progesterone For Traumatic Brain Injury

    Found this study, scientists here reaching Peatiness levels that shouldn't even be possible, combining niacinamide and progesterone, two of Ray's most oft-cited helpful substances in treating experimental brain injury. Combined treatment seems to have been significantly more effective on all...
  7. haidut

    Pregnenolone As A Treatment For Loneliness

    I touched upon this idea/topic in some of my other posts, and just like those other posts, I would like to emphasize here that I am not suggesting steroid supplementation as a substitute for social interaction. The purpose of this post if to provide some insight on the biochemical effects of...
    • haidut
    • Thread
    • 5a-dhp 5α-dhp 5α-dihydroprogesterone allopregnanolone depression hpa loneliness mental health pregnenolone progesterone social isolation
    • Replies: 52
    • Forum: Scientific Studies
  8. L

    Breast Cancer Patients Could Benefit From Controversial Hormone (Progesterone)

    OMG... Breast cancer patients could benefit from controversial hormone "Indeed, progesterone may have an important role to play in the safe and effective management of recurring breast cancer." https://www.sciencedaily.com/releases/2016/12/161209100158.htm :rightagain2
    • lollipop
    • Thread
    • breast cancer health progesterone
    • Replies: 3
    • Forum: Cancer
  9. DaveFoster

    Progesterone Raises SHBG

    The effect of progesterone administration on sex hormone binding globulin binding capacity in women with severe premenstrual syndrome. - PubMed - NCBI Thirty-one women with severe premenstrual syndrome had low sex hormone binding globulin (SHBG) binding capacities 30.2 +/- 9.4 nmol DHT...
  10. haidut

    Natural Progesterone Treats Breast Cancer, Synthetic Progestins Promote It

    I think as early as the 1980s Ray was already writing about the beneficial effects of progesterone for breast cancer and the negative effects of synthetic progestins (most of which are actually 19-nortestosterone derivatives). The pharma industry published fraudulent studies with which to...
    • haidut
    • Thread
    • breast cancer inhibitor megace progesterone progestin synthetic treatment
    • Replies: 14
    • Forum: Scientific Studies
  11. haidut

    Optimal Dose Of Pregnenolone For Androgen Synthesis

    There was a recent discussion about high dose pregnenolone on the forum and some people sent Peat my comments that high dose pregnenolone can inhibit androgen synthesis. Peat replied that he has not seen such effects, but did not directly speak against the idea. Privately, I got quite a few...
    • haidut
    • Thread
    • androgen androstenedione concentration dhea optimal pregnenolone progesterone synthesis topical
    • Replies: 136
    • Forum: Scientific Studies
  12. haidut

    Progesterone May Be Able To Reverse Drug-induced Abortion

    I am posting this purely out of scientific interest. Not interested in joining the abortion debate in any way. Apparently, when progesterone is given in higher doses soon after the abortion pill, many women will not proceed to abort the fetus and will give birth to a healthy offspring. The...
  13. haidut

    5α-Dihydroprogesterone (5α-DHP) Is Androgen/Progesterone Agonist And Pro-hormone For DHT

    If you take a look at a standard diagram of steroigenesis and metabolism you will see that the androgen DHT can be synthesized via only one route, namely DHEA->Androstenedione->Testosterone->DHT. Recently, some studies have shown that DHT can also be synthesized via an alternative pathway, still...
    • haidut
    • Thread
    • 5α-dhp 5α-dihydroprogesterone alternative pathway androgen androgen agonist dht negative feedback mechanism pro-hormone progesterone progesterone agonist progestin prohormone
    • Replies: 25
    • Forum: Scientific Studies
  14. haidut

    5α-Dihydroprogesterone (5α-DHP) Is More Effective Than Progesterone In Lowering Prolactin

    Similar to the stud on estrogen receptor decrease, this study shows that the saturated progesterone metabolite 5α-dihydroprogesterone (5α-DHP) is more effective than progesterone at inhibiting prolactin release from the pituitary. Just as in the estrogen study, the effective doses of 5α-DHP were...
    • haidut
    • Thread
    • 5α-dhp 5α-dihydroprogesterone estrogen inhibitor pituitary progesterone prolactin
    • Replies: 29
    • Forum: Scientific Studies
  15. haidut

    5α-Dihydroprogesterone (5α-DHP) Is More Effective Than Progesterone As Estrogen Antagonist

    The study below showed that the steroid 5α-Dihydroprogesterone (5α-DHP) is more effective that progesterone in decreasing the levels of estrogen receptor and can deliver the same result at quite low doses. The HED for 5α-DHP to achieve 75% inhibition of estrogen receptor levels were just...
    • haidut
    • Thread
    • 5α-dhp 5α-dihydroprogesterone antagonist decrease estrogen progesterone receptor
    • Replies: 5
    • Forum: Scientific Studies
  16. Koveras

    The Role Of Steroids In The Prediction Of Affective Disorders In Adult Men

    https://www.ncbi.nlm.nih.gov/pubmed/27871861?dopt=Abstract
    • Koveras
    • Thread
    • allopregnanolone androsterone anxiety depression pregnenolone progesterone steroids testosterone
    • Replies: 13
    • Forum: Scientific Studies
  17. biggirlkisss

    Progest In Canada

    looking for progest im in canada do you know where i can buy?
  18. haidut

    Pregnenolone & Progesterone Are Both Agonists Of The Androgen Receptor

    Patients with prostate cancer are often treated with a combination of therapies such as 5-AR inhibitors to reduce production of DHT as well as other enzyme inhibitors to reduce conversion of DHEA into other downstream androgens. From the point of view of mainstream "treatment" for prostate...
    • haidut
    • Thread
    • androgen agonist androgenic growth nucleus pregnenolone progesterone prostate study translocation
    • Replies: 24
    • Forum: Scientific Studies
  19. D

    Metabolic Clearance Rate Of Progesterone?

    I have read in several places that large meals increase the metabolic clearance rate of progesterone. Can anybody explain the process? Is it a result of high insulin or cortisol?...... Or.. Is it due to some other process? I'm desperate to understand it but can't find any information on how...
    • domox
    • Thread
    • metabolic clearance progesterone
    • Replies: 3
    • Forum: Health
  20. haidut

    Genomic Mechanism For Beneficial Effects Of Progesterone On Pregnancy / Cancer

    Apparently, the gene Gata2 is crucial for the protective effects of progesterone against estrogen carcinogenicity, as well as for ability to enable pregnancy formation. GATA2 - Wikipedia This study found that progesterone acts as a Gata2 agonist and absence of the gene makes mice infertile as...
    • haidut
    • Thread
    • cancer estrogen fertility gata2 genes pregnancy progesterone study uterine uterus
    • Replies: 2
    • Forum: Scientific Studies
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