pregnenolone

  1. haidut

    Pregnenolone Can Stop Habitual Behavior

    Please don't take this as somehow being a rant against marijuana. It is definitely not. I am much more interested in reversing habit and routine than bashing whatever substance happens to work for people or they just find enjoyable. I posted a few studies on the role of serotonin in the...
  2. haidut

    Stress Increases Risk For Alzheimer Disease (AD)

    This is probably not surprising for any forum user, but official medical guidelines still claim that stress has no known long-term direct effects on health except in "genetically-predisposed individuals". Stress may increase risk for Alzheimer’s disease "...Fewer than ten percent of Alzheimer...
  3. haidut

    Pregnenolone For Protection Against Melanoma

    Ray has written a few times on the topic of "moles" and how he treated his with DHEA, T3 and progesterone. While he did not mention pregnenolone, I always wondered if it would have a similar effect as animal studies with pregnenolone noted lack of melanoma in treated animals subjected to UV...
    • haidut
    • Thread
    • aggressiveness inhibitor melanoma metastases pregnenolone trpm1
    • Replies: 4
    • Forum: Scientific Studies
  4. haidut

    Pregnenolone For Blood Sugar Control

    It was recently discovered that the so-called TRM3 "receptors" in the pancreatic beta cells can be activated by pregnenolone sulfate (PS) at relatively low concentrations and result in insulin release. This makes pregnenolone a potential tool for keeping blood sugar levels normal and can also...
    • haidut
    • Thread
    • beta cells blood glucose homeostasis insulin pancreas pregnenolone trm3
    • Replies: 5
    • Forum: Scientific Studies
  5. haidut

    Pregnenolone Is An Estrogen Antagonist

    This has been stated by Peat a few times but usually the assumption has been that pregnenolone converts into progesterone and that is how it exerts its anti-estrogenic effects. This older study claims that pregnenolone (also called delta-5-pregnenolone) is directly antagonistic to estrogen...
    • haidut
    • Thread
    • antagonist estriol estrogen estrogenic estrone pregnenolone resveratrol stilbestrol
    • Replies: 4
    • Forum: Scientific Studies
  6. H

    7 Weeks Of Pregnenolone Use And Gained A Lot Of Mid Section Fat

    I'm back with a question. Many have been helpful with replying to my last thread. I've read a lot but now a new problem has come up First of all, I feel really good taking pregnenolone. I feel happy and positive. Practically all my menopause problems have disappeared. I used 60 mg of...
  7. M

    Pregnenolone Brand

    Has anyone purchased Pregnenolone from healthnatura.com? Would you please share your results. Your feedback would be appreciated.
    • mother
    • Thread
    • pregnenolone supplemental supplier
    • Replies: 6
    • Forum: Pregnenolone
  8. haidut

    Pregnenolone Is The Most Potent Inhibitor Of The Stress Signal (CRH)

    I think this study should finally put to rest the arguments and debates of whether pregnenolone raises or lowers cortisol, and how it affects the stress response overall. I posted a similar study, which showed that the pregnenolone metabolites progesterone and allopregannolone potently inhibited...
    • haidut
    • Thread
    • acth allopregnanolone artemisia cortisol crf crh inhibitor pregnenolone stress
    • Replies: 116
    • Forum: Scientific Studies
  9. H

    Period Returned, Question About Pregnenolone Dosage

    Hello. I signed up because I have a specific question in regards to the use of pregnenolone. I will do my best to keep it short and to the point. I stopped menstruating 5 months ago. I do have terrible menopause symptoms and started pregnenolone on January 24 (only 12 days ago, 30 mg 2 X...
  10. Y

    Starting Pregnenolone - One Dose Or Divided Doses?

    I am starting pregnenolone, hoping that it would help in my issues with fatigue. Now ive been told to start with 10mg a day, then up it every few days by 10mg. Probably up to around 50-100 max. Im not sure whether to take it in divided doses or not - so say when im ready for 40mg, take 4x10mg...
  11. A

    Doses Of Pregnenolone Over 100 Mg

    How did Ray take 1 gram of pregnenolone daily. And how does anyone take over 100 mg pregnenolone, and not get constipation? Haidutt posted this study showing pregnenolone antagonizes the 5ht3 receptor and causes constipation... https://www.raypeatforum.com/forum/viewtopic.php?t=6609
  12. M

    Pregnenalone And Joint Pain

    This year i have had pretty bad joint problems. This is really the first time this has happened to me and i am a thyroid patient and take 125 T4 and 5 T3. I have been using 2 drops of progestE in the morning and this has really worked well for me overall. However, the elbow pain and achilles...
  13. haidut

    How Pregnenolone And Progesterone Raise Metabolism

    I know pregnenolone/progesterone work via multiple mechanisms such as inhibiting serotonin, opposing estrogen, lowering FFA, etc. However, this method caught my eye and I thought I'd share it since many people here have trouble converting T4 into T3. As you all know both pregnenolone and...
  14. Demyze

    Pregnenolone And DHEA In Traumatic Brain Injury

    Today I heard the first mention of Pregnenolone outside of a "Ray Peat Source". Joe Rogan had a Dr. Mark Gordon on his podcast. Dr. Gordon is an endocrinologist who found that the levels of neurosteroids are very diminished in people who've experienced traumatic brain injuries. After a quick...
    • Demyze
    • Thread
    • brain brain injury dhea health pregnenolone
    • Replies: 6
    • Forum: Health
  15. haidut

    Pregnenolone Increases Maximum Lifespan By 60% (animal Model)

    The study also hints that other hormones from the same cluster may have similar effect. It is also worth noting that the study used a technique to stimulate increased endogenous pregnenolone synthesis rather than use external supplementation. http://www.ncbi.nlm.nih.gov/pubmed/17266678
  16. D

    Topical Pregnenolone

    I have tried many brands of oral pregnenolone over the years and they always cause bad side effects like headache, depersonalization, insomnia and restlessness. This even happens in doses less than 10 mg. I'm thinking of trying pregnenolone topically, by rubbing into the skin. Does anyone have...
  17. A

    Pregnenolone And Its Effect When Using NDT

    So I am taking Armour thyroid as prescribed by my doctor. When I first started one quarter of a grain would give me an adrenaline response and I could only take a total of one to one and a half a grain per day. I started using pregnenolone and it allowed me to tolerate the Armour without any...
  18. I

    Cancer Warning?

    Why does Life Extension have this warning for pregnenolone? "Those with hormonal cancers such as prostate or breast cancer should avoid pregnenolone" This is on Amazon.ca by the way... just found the product there.
  19. L

    How To Start On Pregnenolone?

    Hello. I had this cheap pregnenolone, 10mg each capsule: http://www.swansonvitamins.com/swanson- ... mg-90-caps I just take 1 capsule and fell fatigued and sleepy. Is this normal on this low dose? Maybe should I take it before bed? Thank you very much.
    • Lucas
    • Thread
    • pregnenolone supplemental
    • Replies: 26
    • Forum: Pregnenolone
  20. TheHound

    Any Younger People Have Experience With DHEA/Pregnenolone?

    Preferably 21 and under. Is it worth taking when you're this young for the purpose of trying to increase testosterone and gain muscke?
    • TheHound
    • Thread
    • dhea pregnenolone supplemental
    • Replies: 16
    • Forum: Hormones
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