pregnenolone

  1. haidut

    Pregnenolone Safe And Effective In Big Human Trial For Back Pain

    About 2 years ago I posted about a study that suggested pregnenolone may relieve low-back pain in humans. Pregnenolone Relieves Chronic Low Back Pain (human Study) At the time, a bigger human clinical trial was planned and the results of that trial were just released. Pregnenolone, slowly...
    • haidut
    • Thread
    • back effective endotoxin humans lps pain pregnenolone safe tlr4
    • Replies: 2
    • Forum: Scientific Studies
  2. haidut

    Male Fertility Depends On Intensity Of (sperm) Metabolism

    Yet another aspect of health that turns out to be directly controlled by quality/speed of metabolism. I made a few posts in the past demonstrating that progesterone and pregnenolone activate a calcium channel (CatSper) specific to progesterone, which greatly increases sperm motility...
    • haidut
    • Thread
    • catsper cortisol energy estrogen fertility male metabolism motility oxphos pregnenolone progesterone sperm
    • Replies: 4
    • Forum: Scientific Studies
  3. haidut

    Pregnenolone (P5) Fully Prevents Testicular Atrophy Due To Steroid (ab)use Or High Estrogen

    I often get emails from bodybuilders, athletes and others who have used or currently use steroids and want to either protect themselves while using those steroids or want to recover after long-term usage. It is well-known that most performance enhancing steroids, including plain testosterone (T)...
    • haidut
    • Thread
    • atrophy estradiol estrogen gonads ovaries p5 pregnenolone suppression testicles testosterone
    • Replies: 86
    • Forum: Scientific Studies
  4. haidut

    Allopregnanolone As A Treatment Of Alzheimer Disease (AD)

    It looks like the recent FDA approval of allopregnanolone (ALLO) for postpartum depression may open the floodgates to ton of new research with this steroid, as well as with its reliable precursors such as pregnenolone and progesterone. I posted several studies in the past demonstrating that...
    • haidut
    • Thread
    • ad allo allopregnanolone alzheimer's endotoxin energy inflammation lps metabolism pregnenolone progesterone tlr tlr4 treatment
    • Replies: 0
    • Forum: Scientific Studies
  5. haidut

    Progesterone May Bind And Deactivate Endotoxin (LPS) Directly

    I made a few posts recently discussing the blocking effects of pregnenolone on TLR4 and TLR family receptors in general, and the reduction of systemic inflammation stemming from this blockade/regulation...
    • haidut
    • Thread
    • bind block covalent deactivate endotoxin histamine inflammation lps pregnenolone progesterone react serotonin tlr tlr4
    • Replies: 15
    • Forum: Scientific Studies
  6. haidut

    Consciousness Is Quantum, Can Be Modulated With Specific Chemicals

    Many readers are likely familiar with the theories of Roger Penrose on the topics of consciousness and how it relates to physics and even cosmology. He is perhaps the most vocal proponent of "quantum consciousness" theories, including his own theory known as "orchestrated objective reduction"...
    • haidut
    • Thread
    • anesthetic consciousness inhibit microtubules nuclear spin pregnenolone promote quantum entanglement quantum mechanics resonance tubulin xenon
    • Replies: 108
    • Forum: Scientific Studies
  7. haidut

    Pregnenolone Is A Potent (functional) Endotoxin (TLR4) Antagonist

    It seems that pregnenolone is finally starting to look exciting to the medical industry. In addition for its intensive studies for a variety of mental issues, now studies are coming out demonstrating its endotoxin (LPS) antagonism effects. As most forum users know, endotoxin exerts its effects...
    • haidut
    • Thread
    • alcoholism allopregnanolone alzheimer's antagonist cvd depression endotoxin epilepsy immune system inflammation lps ms multiple sclerosis pregnenolone ptsd schizophrenia sepsis tlr4 tnf
    • Replies: 10
    • Forum: Scientific Studies
  8. haidut

    Pregnenolone Advances As A Treatment For Loneliness In Humans

    A few years ago, I posted a thread on the possibility of using pregnenolone as a treatment for loneliness in humans. Pregnenolone As A Treatment For Loneliness At the time, the studies were mostly based on animal models and a small pilot human study. It seems that the results were promising...
    • haidut
    • Thread
    • clinical trial cure human loneliness mental health pregnenolone stress study treat treatment trial
    • Replies: 46
    • Forum: Scientific Studies
  9. haidut

    Pregnenolone Is Anabolic For Bones

    So much for pregnenolone being an inactive steroid. The study below shows that even very low concentrations of pregnenolone are high anabolic for the bone and its effects are comparable to those of potent steroids like DHT or the well-known androgenic-anabolic steroid (AAS) commonly known as...
    • haidut
    • Thread
    • alp anabolic androgens bone bones effects osteocalcin osteoporosis pregnenolone progestins
    • Replies: 15
    • Forum: Scientific Studies
  10. haidut

    Pregnenolone Is As Potent As Progesterone As An (irreversible) Aromatase Inhibitor

    Progesterone does not need an introduction here and most people are likely aware of its antiestrogenic effects. A few years ago, I posted a thread with an old French study showing that a 500mg daily dose pregnenolone completely blocked estrogen's effects - an effect identical to what...
    • haidut
    • Thread
    • aromatase aromatase inhibition estradiol estrogen fsh irreversible p4 p5 pregnenolone progesterone
    • Replies: 40
    • Forum: Scientific Studies
  11. haidut

    Pregnenolone Is A (functional) Estrogen Antagonist

    About 2 years ago I posted a thread on the antagonism of pregnenolone to estrogen. Pregnenolone Is An Estrogen Antagonist That claim was from a study, which itself referenced an old French study from 1950. I asked @burtlancast to find it and he was able to trace it to a hardcopy of the French...
    • haidut
    • Thread
    • antagonism antagonist des estradiol estrogen estrone pregnenolone stilbestrol
    • Replies: 14
    • Forum: Scientific Studies
  12. haidut

    Pregnenolone Relieves Chronic Low Back Pain (human Study)

    After failing to find any effective treatments for the many ills that plague veterans, doctors are finally turning to older remedies successfully used back in the first half of the 20th century. Pregnenolone is one such remedy and I have been seeing more and more studies and ongoing trials with...
    • haidut
    • Thread
    • anesthetic back pain chronic neurosteroid pregnenolone quality of life veteran
    • Replies: 12
    • Forum: Scientific Studies
  13. haidut

    Cortisol And Aldosterone Cause Vascular Calcification

    In one of his newsletter circa 2015, Ray wrote about the role of aldosterone in heart failure, heart attacks, shock, and edema. He conjectured that aldosterone antagonists would one day be recognized as therapeutic for these conditions. Almost all types of heart disease start with vascular...
    • haidut
    • Thread
    • aldosterone cortisol cvd dhea emodin heart disease mineralocorticoid pregnenolone progesterone receptor salt sodium vascular calcification
    • Replies: 39
    • Forum: Scientific Studies
  14. haidut

    Chronic Stress During Pregnancy Accelerates Fetal Aging And Harms Its Health

    Allopathic medicine still denies that maternal stress during pregnancy affects the child's long term health. If anything, they say that the fetus may experience a slightly increased risk of infection during pregnancy but that risk goes back normal as soon as the baby is born. The main argument...
    • haidut
    • Thread
    • aging chronic cortisol crh fetus health pregnancy pregnenolone premature stress
    • Replies: 5
    • Forum: Scientific Studies
  15. haidut

    Cortisol/Estrogen Impair Fertility; Progesterone/Pregnenolone Improve It

    I posted a study s few months ago about the role of progesterone in ensuring proper sperm motility, and as such being crucial for male fertility. Male Fertility Requires Progesterone And Antagonism Of A PUFA Metabolite This new study from the same authors analyzed the effects of a few other...
    • haidut
    • Thread
    • cortisol estrogen fertility pregnenolone pregnenolone sulfate progesterone sperm motility testosterone
    • Replies: 7
    • Forum: Scientific Studies
  16. haidut

    Finasteride Causes Physical Damage To Nerves, Depression, ED, Steroid Imbalance

    After a decade of denying that a thing such as PFS exists, mainstream medicine seems to be wisening up to the fact that this poison does a lot more than lower the "bad" DHT. Up until very recently, it was common to simply measure blood steroid levels and then declare that they had rebounded upon...
    • haidut
    • Thread
    • 5a-dhp allopregnanolone damage depression dhea dht edd erectile dysfunction finasteride imbalance mdd nerve nervous system pregnenolone progesterone pudental steroid
    • Replies: 41
    • Forum: Scientific Studies
  17. haidut

    New Human Study With Pregnenolone For Treating Autism

    It is to be held at Stanford University and is set to last 14 weeks. No word on dosing but the explanation is that downstream metabolites of pregnenolone are inhibitory in the CNS and can balance the excessive neuroexcitation that is a feature of autism. Given that serotonin is the likely main...
    • haidut
    • Thread
    • autism excitatory human inhibitory pregnenolone serotonin treatment trial
    • Replies: 10
    • Forum: Scientific Studies
  18. haidut

    Pregnenolone As A Possible Treatment Of CFS/ME

    I just posted yet another study showing that CFS/ME is a metabolic disorder that can be treated using various substances that activate PDH and Krebs cycle activity. CFS/ME Once Again Confirmed As A Metabolic Disorder This study took an alternative path and discovered that people with CFS/ME also...
    • haidut
    • Thread
    • cfs chronic fatigue syndrome deficiency me metabolic disorder pregnenolone thyroid trmp3
    • Replies: 27
    • Forum: Scientific Studies
  19. Elchapchapchapo

    Haidut On Insulin Sensitivity / Insulin Resistance

    Insulin resistance is caused by elevated fatty acids (FFA)
  20. BigYellowLemon

    Effects Of Morphine Dependence And Withdrawal On Levels Of Neurosteroids In Rat Brain

    Effects of morphine dependence and withdrawal on levels of neurosteroids in rat brain. - PubMed - NCBI It's a rat study but I think the results are applicable to humans. "The chronic morphine administration (ip) resulted in a marked decrease in the brain concentrations of pregnenolone (PREG)...
    • BigYellowLemon
    • Thread
    • allopregnanolone dhea dhea-s morphine naloxone naltrexone neurosteroid opioids pregnenolone progesterone steroids
    • Replies: 5
    • Forum: Scientific Studies
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