precursor

  1. haidut

    Hypogonadism in older males due to low OXPHOS

    I suspect many readers will simply say "duh!", but believe or not the origin of age-related hypogonadism in males is still considered unknown. Most endocrinologists have discovered experimentally that treating their patients with SERM or AI drugs restores androgens to youthful levels, but the...
  2. haidut

    Androsterone May Be The Main Source Of DHT, Drives Fetal Masculinization

    The study below demonstrates that not only may androsterone be the primary pro-hormone used endogenously for DHT synthesis, it likely also drives the masculinization of sexual organs in the fetus. For a long time it was thought that the so-called "front pathway" using testosterone (T) produced...
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