pdh

  1. haidut

    Restoring Glucose Metabolism May Treat Crohn's Disease (CD)

    As my readers know, the role of metabolism in the initiation and progression of cancer is enjoying renewed interest, after more than a century of neglect and deliberate suppression. One of the promising drugs that target metabolic pathways is dichloroacetate (DCA). The main mechanism of action...
    • haidut
    • Thread
    • cure dca dichloroacetate glucose metabolism ibd inflammatory bowel disease pdh treat
    • Replies: 8
    • Forum: Scientific Studies
  2. haidut

    Forcing The Heart To Burn Glucose Instead Of Fat May Cure Heart Failure

    One of the blockbuster studies I have seen over the last 12 months. It reads as if written by Peat himself and discusses tissue regeneration, Randle cycle, dietary control of metabolism, etc. AFAIK this is the first study brave enough to demonstrate that simply switching fuel types in an...
    • haidut
    • Thread
    • estrogen fatty acid oxidation glucose heart failure niacinamide pdh pdk thiamine
    • Replies: 27
    • Forum: Scientific Studies
  3. haidut

    Increasing Metabolism May Reverse Alzheimer Disease (AD) And General Aging

    Yet another study demonstrating the remarkable parallels between the decline in function (metabolism) and the structural abnormalities that occur not only in specific pathologies such as AD but also in the generalized degradation known as "aging". FDA currently does not recognize aging as a...
    • haidut
    • Thread
    • acetyl-coa ad aging alzheimer's energy metabolism mitochondria oxphos pdh reverse
    • Replies: 3
    • Forum: Scientific Studies
  4. haidut

    Pyrucet - Liquid (ethyl) Pyruvate/Aceatoacetate Mix

    As many forum users know, I have been interested in the Randle Cycle (glucose/fat competition for oxidation) for quite some time. The topic of limiting fatty acid oxidation (FAO) and promoting glucose oxidation is pretty central to the metabolic theory of health. Peat has written many times on...
    • haidut
    • Thread
    • acetoacetate brain dementia endotoxin ethyl acetoacetate ethyl pyruvate fao fatty acid oxidation glucose oxidation gssg heart attack idealabs metabolism nad/nadh oxidation pdh pyruvate redox sepsis stroke
    • Replies: 602
    • Forum: IdeaLabs
  5. haidut

    Saturated Fats (SFA) Increase Glucose Oxidation While PUFA Decrease It

    This is great human study that addresses two key questions people have often asked Peat in regards to SFA vs. PUFA. As Peat has mentioned several times, during stress (exercise in this case) PUFA is preferentially oxidized while SFA is stored. The preferential oxidization of PUFA during stress...
    • haidut
    • Thread
    • differential effects fatty acid oxidation glucose metabolism glucose oxidation metabolism pdh pufa randle cycle saturated fat sfa
    • Replies: 82
    • Forum: Scientific Studies
  6. haidut

    The Anti-cancer Chemical DCA May Treat Chronic Fatigue Syndrome (CFS)

    Over the last 2 years, I posted a few studies on the stress-induced origins of CFS as well as some of details about the pathology such as downregulated activity of the enzyme PDH. That enzyme is crucial for proper glucose metabolism and is downregulated in many other conditions, especially...
    • haidut
    • Thread
    • cfs dca glucose improve metabolism pdh pdk thiamine treat vitamin b1
    • Replies: 17
    • Forum: Scientific Studies
  7. haidut

    Estrogen As The Main Cause Of Cancer And Its Progression

    I think many of the forum users here know about the infamous study that generated a lot of controversy on "scientific" forums like Reddit. It basically showed that the Warburg Effect (overproduction of lactate) is not just an effect but a direct cause of cancer. So, as the top rated comment on...
    • haidut
    • Thread
    • cancer estrogen estrogen receptor fatty acid oxidation glycolysis hif hif-1 hypoxia lactate lactic acid mitochondria nad/nadh pdh pdk pyruvate randle cycle redox homeostasis warburg cause warburg cycle warburg effect
    • Replies: 18
    • Forum: Scientific Studies
  8. haidut

    CFS/ME Once Again Confirmed As A Metabolic Disorder

    I posted previously about recent research indicating that CFS/ME is likely due to hypometabolism caused by environmental stress. CFS Is Likely Hypometabolism Triggered By Environmental Stress The earlier studies found lower activity of the enzyme PDH, which is the rate-limiting step for entrance...
    • haidut
    • Thread
    • atp cfs chronic fatigue syndrome citric acid cycle environmental krebs cycle low me metabolic metabolism pdh
    • Replies: 13
    • Forum: Scientific Studies
  9. haidut

    The Ability To Metabolize Glucose Is Impaired In CFS/ME Patients

    The enzyme pyruvate dehydrogenase (PDH) is perhaps the single most important factor in proper glucose metabolism and it is often severely downregulated (both in function and levels) in a number of diseases, most notably cancer, diabetes and neurodegenerative conditions. Without proper...
    • haidut
    • Thread
    • catabolic cfs lactate magnesium pdh pdk pyruvate thiamine
    • Replies: 31
    • Forum: Scientific Studies
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