parkinson's

  1. Mauritio

    Pregnenolone for the treatment of L-DOPA-induced dyskinesia in Parkinson's disease

    In this study they showed that administering pregnenolone to rats with parkinsons ameliorated the dyskinesia, caused by L-DOPA. The Human equivalent dosages were 75mg, 225mg and 450mg per day. There was a dose-response effect, meaning higher dose = more effective. Now they often get the MoA...
    • Mauritio
    • Thread
    • dopamine dyskinesia parkinson's parkinson's disease pregnenolone
    • Replies: 0
    • Forum: Scientific Studies
  2. Mito

    L-Theanine alleviates MPTP-induced Parkinson's disease

    Abstract We evaluated the neuroprotective effect of L-theanine in Parkinson's disease and the underlying mechanism focusing on WNT/β-catenin signaling mediated by the MAPK pathway. We treated MPTP-induced SH-SY5Y cells with various concentrations of L-theanine (50, 100, 200, and 500 μg/mL), and...
  3. Mauritio

    Cistanche / Echinachoside restores Tyrosine hydroxilase expression to normal in Parkinson's

    It has been established before that cistanche helps with Parkinson's and has a pro-dopamine effect. This study looked a bit deeper into the mechanism of it. In my opinion most noteworthy is the almost complete recovery of Tyrosine hydroxilase in tje sibstabtia nigra of Parkinson's mice...
  4. Soren

    Pregnenolone vs Progesterone for Back Pain, Endotoxin, Parkinsons Disease

    As some on this forum might know my mother suffers from Parkinson's disease which I have been attempting to treat with a number of serotonin blocking substances. Circumstances of the Pandemic and her own disposition have made it very difficult to get her into consistently good habits and...
    • Soren
    • Thread
    • back pain dhea endotoxin parkinson's parkinson's disease pregnenolone progesterone serotonin
    • Replies: 6
    • Forum: Ask For Help or Advice
  5. Mauritio

    Parkinsons Disease is not just a dopamine deficieny - mainstream admits

    This study goes along the lines of what haidut has been posting the last years . Namely that parkinsons disease (PD) is not just caused by a dopamin deficiency, but a serotonin excess . I think this is what the study is pointing to , in a very twisted indirect way ... I guess they dont want to...
  6. charlie

    An Open-Label Pilot Study With High-Dose Thiamine in Parkinson's Disease

    The administration of high doses of thiamine to patients with PD was effective in reversing the parkinsonian symptoms; we then suppose that the parenteral thiamine supplementation may play an important role in restoring the survivor neurons and in limiting the disease progression, and that the...
  7. S

    Lisuride Healed My Parkinson

    A year ago I took Lisuride for the first time and after two weeks of uncontrolled use, the tremor in my hands disappeared permanently. Since the tremor sometimes recurs only when I simultaneously feel symptoms of low dopamine ... this is an exact science. Until then I had experienced tremors in...
  8. methylenewhite

    Parkinson’s Begins In The Gut. One More Study

    New evidence of gut-brain connection in Parkinson's disease https://www.cell.com/neuron/fulltext/S0896-6273(19)30488-X An important and rigorous new animal study led by scientists at Johns Hopkins University has demonstrated how the misfolded proteins thought to cause Parkinson's disease may...
  9. haidut

    The Protein In Fish, Not Omega-3, May Be Protective Against Brain Disease

    Over the last 2 decades thousands of studies were published on the purported benefits of omega-3 fats commonly found in cold water fish. However, every large human trial with omega-3 either failed to find benefit or even found increased risk of harm. Despite that fact, there is very strong...
    • haidut
    • Thread
    • amyloid calcium blocker calcium-binding cancer fish neurodegenerative parkinson's parvalbumin prevention protective protein seafood
    • Replies: 15
    • Forum: Scientific Studies
  10. P

    Statins May Exert Beneficial Effects Through A Pathway Other Than It's Cholesterol Lowering Action

    Was surprised when saw a study showing statins have positive effects on bones, did a bit of searching and it turned out that it has some positive action,generally, through inhibiting rho kinase, which also is protective against heart disease. Im not promoting statin use at all(for obvious...
    • paymanz
    • Thread
    • aspirin bone health calcitriol cancer cholesterol depression diabetes erectile dysfunction fibrosis histamine hypertension osteocalcin osteoporosis parkinson's rho-kinase salicylates statins taurine vitamin d
    • Replies: 8
    • Forum: Articles & Scientific Studies
  11. haidut

    Lanosterol - Liquid Lanosterol For Lab/R&D

    I guess most people on the forum who have heard of lanosterol know it in the context of treating cataracts. Lanosterol - Wikipedia There is a company out there who used to sell lanosterol as eye drops and it is insanely expensive - $100 for a meager 10mg lanosterol. Anyways, lanosterol is...
    • haidut
    • Thread
    • alzheimer's anti-cancer anti-catabolic anti-cortisol anti-endotoxin antibacterial antiviral cataracts dopaminergic fertility flu huntington's lanosterol metabolism parkinson's protein aggregation tetanus tlr4 uncoupler uncoupling
    • Replies: 160
    • Forum: IdeaLabs
  12. haidut

    White-collar Jobs Linked To ALS And Parkinson

    Ever since ALS and Parkinson were formally introduced into the medical vocabulary, the medical industry has been trying to explain their increasing incidence with a variety of bizarre genetic stories. The genetic explanation started to collapse in the late 90s when it became evident that 90% of...
    • haidut
    • Thread
    • administrative als jobs occupation office parkinson's stress white-collar
    • Replies: 15
    • Forum: Scientific Studies
  13. SQu

    KMUD 170317 Endocrinology, Parkinson's 1

    So I just did this, would appreciate it someone would check, I couldn't identify one or two words. Transcribed by SQu KMUD 17-13-17 endocrinology part 1 Parkinson’s Introduction Greets Ray Peat at 2:52 More intro History of medical research from Chinese to19th Century germ theory 5:52 AM...
  14. Dan W

    KMUD: 3-17-17 Endocrinology (Part 1): Parkinson's

    Direct MP3 link | Podcast setup A thought-provoking session, worth a listen whether you're interested in Parkinson's disease or not. Donate to support KMUD here.
  15. haidut

    Caffeine Protects Against Dementia (AD), ALS, Parkinson, And Huntington Disease

    The link between caffeine intake and lower risk of neurodegenerative conditions has been established before but the mechanism of action was unknown. This study discovered one possible mechanism and also confirmed the associative findings in vivo using a mouse model. The HED was 150mg - 300mg...
    • haidut
    • Thread
    • als alzheimer's caffeine dementia huntington's nmnat2 parkinson's protective treatment
    • Replies: 12
    • Forum: Scientific Studies
  16. Mito

    Combating Iron In The Brain: Researchers Find Anti-aging Micromolecule

    The older we get, the more our brain ages. Cognitive abilities decline and the risk of developing neurodegenerative diseases like dementia, Alzheimer’s and Parkinson’s disease or having a stroke steadily increases. A possible cause is the accumulation of iron molecules within neurons, which...
  17. haidut

    5α-Dihydroprogesterone (5α-DHP) - The Primary Progestogen Neurosteroid

    It has been shown that progesterone rapidly metabolizes into more saturated metabolites such as 5α-Dihydroprogesterone (5α-DHP) and tetrahydroprogesterone (also known as allopregnanolone or Allo). The enzyme 5-AR is the one responsible for the saturation, just as it is responsible for the...
    • haidut
    • Thread
    • 5α-dhp 5α-dihydroprogesterone alzheimer's antidepressant antiestrogen brain cns dementia gaba glycine ms neurosteroid parkinson's protective
    • Replies: 25
    • Forum: Scientific Studies
  18. haidut

    Vitamin D3 Extends Lifespan By Preventing Toxic Protein Buildup

    Over the last 6-9 months I noticed that often people who communicate with Peat over email get a recommendation to supplement with vitamin D. When asked why, Peat said that he knows quite a few people who recovered from "very serious symptoms" by using vitamin D. Well, this new study shows that...
    • haidut
    • Thread
    • aging alzheimer's brain cholecalciferol condition extension homeostasis lifespan neurodegenerative parkinson's protein study vitamin d
    • Replies: 21
    • Forum: Scientific Studies
  19. haidut

    RoundUp (glyphosate) Linked To Alzheimers, Parkinson And ALS

    I posted about a similar study a few months ago, but this time the scientists are directly making the claim that RoundUp is causally involved with these conditions. The mechanism of action is again glycine antagonism / deletion by glyphosate. Monsanto's Roundup Weedkiller Linked to Alzheimer's...
    • haidut
    • Thread
    • als alzheimer's glycine glyphosate parkinson's roundup
    • Replies: 4
    • Forum: Scientific Studies
  20. P

    Reduced Plasma Taurine Level In Parkinson's Disease: Association With Motor Severity And Levodopa Tr

    http://www.ncbi.nlm.nih.gov/pubmed/26004911 Abstract PURPOSE: This study aimed to evaluate the level of taurine in plasma, and its association with the severity of motor and non-motor symptoms (NMS) and chronic levodopa treatment in Parkinson's disease (PD). PATIENTS AND METHODS: Plasma...
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