parkinson's disease

  1. Candeias

    L-type calcium channel blockers (which cross the blood-brain barrier) reverse Parkinson's disease neurons

    ‘Rejuvenation’ protects neurons in mouse models of Parkinson’s disease "Our studies suggest that the unusual reliance of these neurons on L-type Cav1.3 Ca2+ channels to drive their maintained, rhythmic pacemaking renders them vulnerable to stressors thought to contribute to disease progression...
  2. Candeias

    (A non-protection of) Dopamine oxidation metabolites as a cause of Parkinson's disease

    5-S-cysteinyl-dopamine, a neurotoxic endogenous metabolite of dopamine: Implications for Parkinson's disease "Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide and is characterized for being an idiopathic and multifactorial disease. Extensive research has...
  3. Mauritio

    Pregnenolone for the treatment of L-DOPA-induced dyskinesia in Parkinson's disease

    In this study they showed that administering pregnenolone to rats with parkinsons ameliorated the dyskinesia, caused by L-DOPA. The Human equivalent dosages were 75mg, 225mg and 450mg per day. There was a dose-response effect, meaning higher dose = more effective. Now they often get the MoA...
    • Mauritio
    • Thread
    • dopamine dyskinesia parkinson's parkinson's disease pregnenolone
    • Replies: 0
    • Forum: Scientific Studies
  4. skuabird

    Need help- DHT source

    My husband's health has been deteriorating. To make a long story short, he was treated for testicular cancer almost five years ago. I have seen a decline in his libido, energy and motivation for a time since then. This last year being the worse- I thought for sure he'd be eligible for HRT but he...
    • skuabird
    • Thread
    • dht parkinson's disease parkinsonism
    • Replies: 33
    • Forum: Male Issues
  5. Sefton10

    Mitochondrial Calcium: Effects of Its Imbalance in Disease

    Mitochondrial Calcium: Effects of Its Imbalance in Disease https://www.mdpi.com/2076-3921/11/5/801/htm
    • Sefton10
    • Thread
    • alzheimer alzheimer disease atp calcium huntington's mitochondria parkinson's disease
    • Replies: 3
    • Forum: Calcium
  6. Soren

    Pregnenolone vs Progesterone for Back Pain, Endotoxin, Parkinsons Disease

    As some on this forum might know my mother suffers from Parkinson's disease which I have been attempting to treat with a number of serotonin blocking substances. Circumstances of the Pandemic and her own disposition have made it very difficult to get her into consistently good habits and...
    • Soren
    • Thread
    • back pain dhea endotoxin parkinson's parkinson's disease pregnenolone progesterone serotonin
    • Replies: 6
    • Forum: Ask For Help or Advice
  7. Mauritio

    Parkinsons Disease is not just a dopamine deficieny - mainstream admits

    This study goes along the lines of what haidut has been posting the last years . Namely that parkinsons disease (PD) is not just caused by a dopamin deficiency, but a serotonin excess . I think this is what the study is pointing to , in a very twisted indirect way ... I guess they dont want to...
  8. charlie

    An Open-Label Pilot Study With High-Dose Thiamine in Parkinson's Disease

    The administration of high doses of thiamine to patients with PD was effective in reversing the parkinsonian symptoms; we then suppose that the parenteral thiamine supplementation may play an important role in restoring the survivor neurons and in limiting the disease progression, and that the...
  9. haidut

    Drop In Androgen Levels Causes Parkinson Disease (PD), DHT Reverses It

    Yet another study demonstrating that many of the so-called chronic, degenerative and above all "mysterious" conditions often have quite a simple cause and, potentially, treatment. There is no need for mutated genes or complex interactions of genes with environment that nobody can decipher...
    • haidut
    • Thread
    • 5α-dihydrotestosterone androgen brain castration cns dht dopamine gdnf inos neurodegeneration neurodegenerative neuroinflammation nitric oxide no parkinson parkinson's disease testosterone α-synuclein
    • Replies: 41
    • Forum: Scientific Studies
  10. Tristan Loscha

    Parkinsonism As A Third Wave Of The COVID-19 Pandemic?

    Parkinsonism as a Third Wave of the COVID-19 Pandemic? Article type: Review Article Authors: Beauchamp, Leah C.a; b | Finkelstein, David I.a | Bush, Ashley I.a; c | Evans, Andrew H.d | Barnham, Kevin J.a; b; c; * Affiliations: [a] Florey Institute of Neuroscience and Mental Health, Parkville...
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