p5

A study not directly dealing with disease, though its findings are probably relevant for all diseases. It demonstrates that in addition to the so-called "active transport", which we have been told is the dominant mechanism in steroid absorption and intracellular relevance, there also exists a...

A great new study, and with humans too! As the study aptly demonstrates, the primary driver of cocaine cravings is likely stress and the anxiety it causes. This finding is another corroboration of the findings of the great Rat Park experiment/study on "addiction". In the study below, the...

One of the few direct studies with P5 in-vivo, though that may be changing as I noticed the rate of articles on P5 has been rising over the last 5-6 years. This study used four (4) administrations of P5, at a HED of just 0.3mg/kg, 1, 6, 12, and 18 hours after the (ischemic) stroke was caused...

As many of my readers know, the first step in steroid synthesis is the so-called "side-chain cleavage", which converts cholesterol into pregnenolone (P5). That step is known as the rate-limiting step in the steroid cascade, and its function depends on the redox status and ATP levels. In other...

Take this study with a grain of salt simply because the only link to it is from a scientific conference, which means the study is not yet published in peer-reviewed journals. Yet, the results it reports are quite interesting. Namely, a single 100mg pregnenolone (P5) dose accelerated recovery...

About a month ago, I made a post in regards to aspirin becoming a new treatment for osteoporosis. Several months ago, I made another post about an in-vitro study demonstrating powerful anabolic effects of pregnenolone (P5) on bones. Apparently, the protective effects of P5 on bone health are...

I often get emails from bodybuilders, athletes and others who have used or currently use steroids and want to either protect themselves while using those steroids or want to recover after long-term usage. It is well-known that most performance enhancing steroids, including plain testosterone (T)...

Progesterone does not need an introduction here and most people are likely aware of its antiestrogenic effects. A few years ago, I posted a thread with an old French study showing that a 500mg daily dose pregnenolone completely blocked estrogen's effects - an effect identical to what...