p4

  1. haidut

    Parkinson Disease (PD) is metabolic, of gut origin, progesterone to the rescue

    One of the most famous sayings in medicine since antiquity has been Hippocrates' quip that "all disease begins in the gut". Despite millennia that passed since that phrase was first uttered and countless "advances" in our knowledge of diseases, evidence continues to accumulate that the ancients...
  2. haidut

    Cells preferentially accumulate Pregnenolone (P5), Progesterone (P4), and DHEA

    A study not directly dealing with disease, though its findings are probably relevant for all diseases. It demonstrates that in addition to the so-called "active transport", which we have been told is the dominant mechanism in steroid absorption and intracellular relevance, there also exists a...
  3. P

    Progesterone receptors and serotonin levels in colon epithelial cells from females with slow transit constipation (P4 lowers SERT)

    Abstract link to study Background: Females with slow transit constipation (STC) exhibit progesterone receptor (P4R) overexpression in colon muscle that impair their contractility. These studies examined whether these patients have an overexpression of P4R in epithelial cells and...
  4. haidut

    Pregnenolone Is As Potent As Progesterone As An (irreversible) Aromatase Inhibitor

    Progesterone does not need an introduction here and most people are likely aware of its antiestrogenic effects. A few years ago, I posted a thread with an old French study showing that a 500mg daily dose pregnenolone completely blocked estrogen's effects - an effect identical to what...
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