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osteoporosis

  1. haidut

    Low vitamin D and HIGH (not low) PTH predict bone deterioration

    A great new study, which would hopefully trigger a re-assessment of the current approaches in treating osteoporosis/osteopenia. Namely, one of the core therapies for deteriorating bone health/density (usually associated with aging, glucocorticoid treatment, kidney disease, etc) is administration...
    • haidut
    • Thread
    • bone cholecalciferol osteopenia osteoporosis parathyroid pth vitamin d
    • Replies: 0
    • Forum: Scientific Studies
  2. A

    Reversal of alopecia areata and osteoporosis by activation of bile acid receptor

    Alopecia areta (AA) is one of the most common immune diseases characterized by a chronic inflammatory reaction to hair follicles [1,2]. The lifetime incidence of AA is approximately 2% worldwide, and there was no significant difference between the sexes. Alopecia areata is an autoimmune disorder...
  3. A

    Lactate dehydrogenase inhibition increases osteogenic potential

    Cellular bioenergetics is a promising new therapeutic target in aging, cancer, and diabetes as these pathologies are characterized by a shift from oxidative to glycolytic metabolism. We have previously reported such glycolytic shift in aged bone as a major contributor to bone loss in mice. We...
  4. CreakyJoints

    Deer antler extract and possible applications for degenerative bone and joint disorders.

    I recently came across these (the oldest of which is from 2019) and found them quite interesting. I wonder if anyone has any thoughts, experiences, or any more literature on the subject? Bioactive Molecular Discovery Using Deer Antlers as a Model of Mammalian Regeneration Deer antler extract...
  5. haidut

    DHT restores anabolism / vitality / sexuality even in 90+ y.o. males

    A great study, a true blast from the (better) past, when androgenic steroids and especially DHT were not considered the devil reincarnate, but were commonly used for all types of ailments, including the broad physiological and psychological symptoms of aging such as sarcopenia (muscle loss)...
    • haidut
    • Thread
    • anabolism androgen dht euphoria libido osteoporosis sarcopenia sexuality stanolone vitality
    • Replies: 37
    • Forum: Scientific Studies
  6. Mauritio

    Cistanche increases steroidogenic enzymes, lowers NO, helps osteoporosis and Alzheimer's

    I posted these studies in another thread, but I feel they deserve their own thread as they show that cistanche is helping the body on a systemic level. A few new studies on cistanche tubulosa: This one shows that cistanche increases biosynthesis of testosterone by increasing important...
    • Mauritio
    • Thread
    • alzheimer's cistanche cistanche tubulosa enzymes nitric oxide no osteoporosis steroids testosterone
    • Replies: 186
    • Forum: Scientific Studies
  7. haidut

    Pregnenolone (P5) - A New Osteoporosis Drug

    About a month ago, I made a post in regards to aspirin becoming a new treatment for osteoporosis. Several months ago, I made another post about an in-vitro study demonstrating powerful anabolic effects of pregnenolone (P5) on bones. Apparently, the protective effects of P5 on bone health are...
    • haidut
    • Thread
    • endotoxin inflammation lps menopause osteoporosis p5 pregnenolone prevent treat
    • Replies: 3
    • Forum: Scientific Studies
  8. haidut

    Aspirin - A New Osteoporosis Drug

    A study published almost a decade ago made the bold claim that aspirin may be a novel drug for osteoporosis. [Effect of aspirin administration for the treatment of osteoporosis in ovariectomized rat model]. - PubMed - NCBI However, the study did not get much traction and was in fact mocked by...
    • haidut
    • Thread
    • aspirin bmd bone inflammation osteoporosis prostaglandins therapeutic treat
    • Replies: 12
    • Forum: Scientific Studies
  9. haidut

    Osteoporosis Is Caused By Mitochondrial Dysfunction Driven By Nitric Oxide (NO)

    Let’s repeat the mantra one more time – structure and function cannot be separated, they are mutually dependent at every level of reality/life. As such, it is little surprise (to us) that a structural disorder like osteoporosis may be caused by a deficiency in energy production. Yet, despite...
    • haidut
    • Thread
    • bone breakdown cause cytochrome c cytochrome c oxidase damage dysfunction energetic inflammation metabolic mitochondria nitric oxide no osteoclasts osteoporosis rankl resorption stress
    • Replies: 10
    • Forum: Scientific Studies
  10. haidut

    Pregnenolone Is Anabolic For Bones

    So much for pregnenolone being an inactive steroid. The study below shows that even very low concentrations of pregnenolone are high anabolic for the bone and its effects are comparable to those of potent steroids like DHT or the well-known androgenic-anabolic steroid (AAS) commonly known as...
    • haidut
    • Thread
    • alp anabolic androgens bone bones effects osteocalcin osteoporosis pregnenolone progestins
    • Replies: 15
    • Forum: Scientific Studies
  11. haidut

    High Serotonin Is A Likely Cause Of Most Types Of Fractures

    Peat wrote in a few articles that serotonin is extremely detrimental for bone growth and that anti-serotonin drugs are anabolic for the bone. Serotonin is the most potent inducer of cortisol synthesis, which is probably the main mechanism behind its bone destructive effects. However, serotonin...
    • haidut
    • Thread
    • 5-ht bone health bone loss bones cause detrimental fractures increase osteopenia osteoporosis risk serotonin
    • Replies: 2
    • Forum: Scientific Studies
  12. P

    Statins May Exert Beneficial Effects Through A Pathway Other Than It's Cholesterol Lowering Action

    Was surprised when saw a study showing statins have positive effects on bones, did a bit of searching and it turned out that it has some positive action,generally, through inhibiting rho kinase, which also is protective against heart disease. Im not promoting statin use at all(for obvious...
    • paymanz
    • Thread
    • aspirin bone health calcitriol cancer cholesterol depression diabetes erectile dysfunction fibrosis histamine hypertension osteocalcin osteoporosis parkinson's rho-kinase salicylates statins taurine vitamin d
    • Replies: 6
    • Forum: Articles & Scientific Studies
  13. Drareg

    Sex Hormone-binding Globulin In Osteoporosis

    Sex hormone-binding globulin in osteoporosis. - PubMed - NCBI Abstract Sex hormone-binding globulin (SHBG) is a plasma glycoprotein that binds with high affinity to sex steroids, most notably 5alpha-dihydrotestosterone, testosterone, and 17beta-estradiol, thereby regulating their...
  14. haidut

    SSRI Drugs Damage Bone By Increasing Adrenaline

    Over the last few years there have been a number of studies linking SSRI use with increased risk of fracture. Subsequent studies found this link to be definitively causal - i.e. SSRI drugs cause those fractures. However, the mechanism of action was officially ascribed to the medical...
    • haidut
    • Thread
    • adrenaline beta-blocker bone loss osteoporosis reverse serotonin ssri sympathetic
    • Replies: 9
    • Forum: Scientific Studies
  15. P

    LRP5 Controls Bone Formation By Inhibiting Serotonin Synthesis In The Duodenum

    LRP5 - Wikipedia im so interest to find any info on how increase Lrp5(it strongly inhibit gut serotonin release) , only thing i found that upregulates the synthesis of it is vitamin D, and also Cholesterol. but who knows, maybe serotonin lowering effect of salt works through this pathway...
    • paymanz
    • Thread
    • antiserotonin bone curcumin inflammation jnk lrp5 obesity osteoarthritis osteoporosis serotonin serotonin depletion study vitamin d
    • Replies: 4
    • Forum: Articles & Scientific Studies
  16. haidut

    Low-dose Glycine As A Treatment For Menopause, Osteoporosis, Obesity

    This study is a great find IMO but unfortunately it uses the elevations in blood levels of estrogen as a reason to label glycine as estrogenic, which is wrong. Just like progesterone, glycine can trigger release of estrogen from tissues/cells and this elevates the blood levels while lowering it...
  17. haidut

    Transdermal Progesterone Reverses Osteoporosis

    I posted this study in the Progestene thread, but I thought that in light of its spectacular claims/results it deserved a separate thread. The dose of progesterone used was not high at all - 7mg twice daily for a total of 14mg daily. However, the study period was quite long (6 years) so it might...
  18. haidut

    Aspirin As A "novel" Drug Against Osteoporosis

    If aspirin imporved bone density in this animal model of osteoporosis. So, combining with vitamin K (as Peat suggests) may have an even stronger effect on bone health. [Effect of aspirin administration for the treatment of osteoporosis in ovariectomized rat model]. - PubMed - NCBI "...Aspirin...
  19. M

    It's Rainmaking Time - Energy Protective Materials (June 14)

    It’s Rainmaking Time -­ Energy-­Protective Materials (June 2014) KG: Kim Greenhouse RP: Ray Peat PhD Transcribed by moss Verified by Sheila http://itsrainmakingtime.com/_radioshows/140602Peat.mp3 Ladies and gentlemen, welcome to It’s Rainmaking Time. This is Kim Greenhouse and it’s an...
    • moss
    • Thread
    • co2 edema hypertension osteoporosis ph pregnenolone rainmaking time ray peat salt thyroid transcripts x-ray
    • Replies: 9
    • Forum: Audio Interview Transcripts
  20. loess

    KMUD: Hair Loss, Inflammation and Osteoporosis (2012)

    Raymond Peat, Ph.D. HAIR LOSS, INFLAMMATION AND OSTEOPOROSIS KMUD “Ask Your Herb Doctor” (2012) HD - Andrew Murray and Sarah Johannesen-Murray RP - Ray Peat HD: Dr Peat, could you please let listeners know about your academic background? RP: I studied biology at the University of Oregon...
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