osteoporosis

I recently came across these (the oldest of which is from 2019) and found them quite interesting. I wonder if anyone has any thoughts, experiences, or any more literature on the subject? Bioactive Molecular Discovery Using Deer Antlers as a Model of Mammalian Regeneration Deer antler extract...

A great study, a true blast from the (better) past, when androgenic steroids and especially DHT were not considered the devil reincarnate, but were commonly used for all types of ailments, including the broad physiological and psychological symptoms of aging such as sarcopenia (muscle loss)...

I posted these studies in another thread, but I feel they deserve their own thread as they show that cistanche is helping the body on a systemic level. A few new studies on cistanche tubulosa: This one shows that cistanche increases biosynthesis of testosterone by increasing important...

About a month ago, I made a post in regards to aspirin becoming a new treatment for osteoporosis. Several months ago, I made another post about an in-vitro study demonstrating powerful anabolic effects of pregnenolone (P5) on bones. Apparently, the protective effects of P5 on bone health are...

A study published almost a decade ago made the bold claim that aspirin may be a novel drug for osteoporosis. [Effect of aspirin administration for the treatment of osteoporosis in ovariectomized rat model]. - PubMed - NCBI However, the study did not get much traction and was in fact mocked by...

Let’s repeat the mantra one more time – structure and function cannot be separated, they are mutually dependent at every level of reality/life. As such, it is little surprise (to us) that a structural disorder like osteoporosis may be caused by a deficiency in energy production. Yet, despite...

So much for pregnenolone being an inactive steroid. The study below shows that even very low concentrations of pregnenolone are high anabolic for the bone and its effects are comparable to those of potent steroids like DHT or the well-known androgenic-anabolic steroid (AAS) commonly known as...

Peat wrote in a few articles that serotonin is extremely detrimental for bone growth and that anti-serotonin drugs are anabolic for the bone. Serotonin is the most potent inducer of cortisol synthesis, which is probably the main mechanism behind its bone destructive effects. However, serotonin...

Was surprised when saw a study showing statins have positive effects on bones, did a bit of searching and it turned out that it has some positive action,generally, through inhibiting rho kinase, which also is protective against heart disease. Im not promoting statin use at all(for obvious...

Sex hormone-binding globulin in osteoporosis. - PubMed - NCBI Abstract Sex hormone-binding globulin (SHBG) is a plasma glycoprotein that binds with high affinity to sex steroids, most notably 5alpha-dihydrotestosterone, testosterone, and 17beta-estradiol, thereby regulating their...

Over the last few years there have been a number of studies linking SSRI use with increased risk of fracture. Subsequent studies found this link to be definitively causal - i.e. SSRI drugs cause those fractures. However, the mechanism of action was officially ascribed to the medical...

LRP5 - Wikipedia im so interest to find any info on how increase Lrp5(it strongly inhibit gut serotonin release) , only thing i found that upregulates the synthesis of it is vitamin D, and also Cholesterol. but who knows, maybe serotonin lowering effect of salt works through this pathway...

This study is a great find IMO but unfortunately it uses the elevations in blood levels of estrogen as a reason to label glycine as estrogenic, which is wrong. Just like progesterone, glycine can trigger release of estrogen from tissues/cells and this elevates the blood levels while lowering it...

I posted this study in the Progestene thread, but I thought that in light of its spectacular claims/results it deserved a separate thread. The dose of progesterone used was not high at all - 7mg twice daily for a total of 14mg daily. However, the study period was quite long (6 years) so it might...

If aspirin imporved bone density in this animal model of osteoporosis. So, combining with vitamin K (as Peat suggests) may have an even stronger effect on bone health. [Effect of aspirin administration for the treatment of osteoporosis in ovariectomized rat model]. - PubMed - NCBI "...Aspirin...

It’s Rainmaking Time -­ Energy-­Protective Materials (June 2014) KG: Kim Greenhouse RP: Ray Peat PhD Transcribed by moss Verified by Sheila http://itsrainmakingtime.com/_radioshows/140602Peat.mp3 Ladies and gentlemen, welcome to It’s Rainmaking Time. This is Kim Greenhouse and it’s an...

Raymond Peat, Ph.D. HAIR LOSS, INFLAMMATION AND OSTEOPOROSIS KMUD “Ask Your Herb Doctor” (2012) HD - Andrew Murray and Sarah Johannesen-Murray RP - Ray Peat HD: Dr Peat, could you please let listeners know about your academic background? RP: I studied biology at the University of Oregon...

I was shocked to find this "editorial" in, of all places, the BMJ since it is known as one of the bastions of modern "medicine" (together with NEJM). I hope this is a good sign that not all allopathic doctors are villains. Either way, it makes for a very interesting read and it reads as if Peat...

Not sure if Peat has mentioned this before, but I decided to post it anyway. The take of the story is that serotonin antagonists, and especially 5-HT3 antagonists like ondansetron would be very good treatment for osteoporosis. Pharmacological inhibition of gut-derived serotonin synthesis is a...

That is a lot of K2. Vitamin K administration to elderly patients with osteoporosis induces no hemostatic activation, even in those with suspected vitamin K deficiency http://www.ncbi.nlm.nih.gov/pubmed/11846334 The administration of menaquinone-4 (MK-4), one of subclasses of vitamin K2...