obesity

  1. haidut

    PUFA, From Formula Feeding Or Maternal Obesity, May Cause Leukemia

    Another great study, and one of the few that dares point the finger at medicine's Holy Grail - the "essential fatty acids". As the study aptly says, high levels of PUFA in the blood and especially higher levels of linoleic acid predict subsequent development of acute lymphoblastic leukemia (ALL)...
  2. haidut

    Obesity Increasing; Is NOT Due To The Cliche Urban, Gluttonous, Sedentary Lifestyle

    The study below shows that obesity rates are rising worldwide. A doctor would immediately suggest that this is due to urban overpopulation, with hordes of gluttonous, chips-eating, video-game-playing, sedentary, bored people who do little more than eat and sleep. However, the study below found...
  3. haidut

    Mitochondria Likely Determine Disease Risk, Not The Main Genome / DNA

    As I mentioned several times on Danny's podcasts, the genetic approach to curing disease has not really produced much for the last 80 years so little by little the industry is shifting its focus on metabolism. However, that shift won't happen overtly by admitting metabolism is key. Rather, it...
  4. P

    “NO” To Autophagy: Fat Does The Trick For Diabetes

    “NO” to Autophagy: Fat Does the Trick for Diabetes During the progression from obesity to diabetes, a critical attribute is inability to maintain metabolic homeostasis under excessive energy and nutrient exposure, which triggers insulin resistance. Intensive research efforts have linked chronic...
  5. haidut

    Saturated Fat (palmitate) Does NOT Activate TLR4

    We must have had hundreds of discussions on this topic on the forum. Some forum users strongly believe that saturated fat (SFA) increases inflammation by binding to and activating the endotoxin (LPS) receptor TLR4. Among all SFA, palmitate is the one most commonly blamed and has been...
  6. haidut

    The Benefits Of Fasting Are Due To Lowering Endotoxin (LPS), Not Less Calories

    As many of you know, the argument for/against fasting has been raging on the forum for several years at this point. While Ray has spoken several times favorably about potentially skipping a meal or two, he has repeatedly said that chronic fasting is not something he recommends due to its...
  7. Hans

    Excess Iron Is Associated With Diabetes, Obesity And Metabolic Syndrome

    By this time we are all aware that iron should be kept low. In this study iron is involved in insulin resistance, inflammation and fat gain. Iron homeostasis: a new job for macrophages in adipose tissue? "men and women in the highest quintile of serum ferritin (Ft) levels – the primary...
  8. haidut

    Sterilizing The Gut Restores Insulin Sensitivity By Reducing Fatty Acid Oxidation

    I am posting this study just as an example of how important the role of endotoxin is in insulin resistance and diabetes. Similarly to the human study with aspirin, sterilizing the gut with antibiotics did not reduce the weight in the obese subjects (in this case mice). So, obesity may be a less...
  9. haidut

    Elevated PUFA In Blood Drive Metabolic Syndrome And Diabetes

    Some good evidence on the role of PUFA and inflammation in obesity and diabetes. The findings that FFA are elevated in obese people is not surprising and even mainstream medicine has wisened up to that fact. The surprising (for the authors) part was that unsaturated fats were involved in the...
  10. haidut

    Only Dietary Fat, Not Protein Or Sugar (sucrose), Drives Obesity

    This is a recent study that confirms another controversial one I posted on the forum more than a year ago. https://raypeatforum.com/community/threads/low-protein-high-carb-diet-healthier-than-caloric-restriction.6909/ The newer study also had some unexpected findings. For example, increasing...
  11. haidut

    Another Obesity Paradox - Higher BMI Linked To Lower Breast Cancer Risk

    I am sure this study will generate a lot of controversy, but the reductions in risk are pretty significant and hard to argue with. The fact that there was no threshold at which BMI started being protective suggests that the protective effect is indeed drive by increased mass. The study only...
  12. haidut

    Carbon Dioxide (CO2) Therapy Reduces Belly Fat In Humans

    Finally some good news out of mainstream medicine! I am quite happy to see that the crucial role of carbon dioxide in health and metabolism is finally being recognized. This was a human study, which makes it even more relevant. Finally, given that belly fat is primarily driven by cortisol is...
  13. haidut

    Serotonin Causes Obesity And Diabetes In Humans

    This study is presented as groundbreaking and unexpected but in fact big pharma has been quietly working on anti-serotonin therapy for obesity/diabetes for more than a decade. I think the importance of this study is the admission that serotonin causes obesity/diabetes in humans, as one of the...
  14. haidut

    Serotonin/endotoxin/PUFA As Primary Causes Of Depression And Diabetes; Can Be Easily Blocked

    This is one of the unique studies that breaks away from the mainstream dogma that serotonin is the "happy hormone" and increasing it with drugs like SSRI can lead to nothing but goodness. The study not only directly states that past/current SSRI use is a risk for developing diabetes but show how...
  15. haidut

    The Financial Crisis In 2008 Increased Obesity, Diabetes And Mental Illness

    So much for these issues being "predominantly genetically driven" as mainstream medicine likes to proclaim. It would have been nicer if the authors of the study also tested thyroid function as that would have directly implicated declining metabolism in these health issues strongly linked to...
  16. P

    Glycine Enhances Expression Of Adiponectin And IL-10 In 3T3-L1 Adipocytes Without Affecting Adipogen

    https://www.ncbi.nlm.nih.gov/pubmed/29356901 Amino Acids. 2018 Jan 22. doi: 10.1007/s00726-018-2537-3. [Epub ahead of print] Glycine enhances expression of adiponectin and IL-10 in 3T3-L1 adipocytes without affecting adipogenesis and lipolysis. Chen J1, Ma X1, Yang Y1, Dai Z1, Wu Z2,3, Wu G1,4...
  17. haidut

    Estrogen+PUFA Esters May Drive Obesity; Most Doctors Have Not Even Heard Of Them

    An unassailable dogma in endocrinology is that menopause is characterized by low estrogen levels. The fact that plasma levels are only indicative of ovarian activity is conveniently overlooked, as is the fact that fat tissue grows after menopause and fat is the primary source of estrone (estrone...
  18. P

    Low Dose Doxycycline Decreases Systemic Inflammation And Improves Glycemic Control, Lipid Profiles,

    Low dose doxycycline decreases systemic inflammation and improves glycemic control, lipid profiles, and islet morphology and function in <i>db/db</i> mice Low dose doxycycline decreases systemic inflammation and improves glycemic control, lipid profiles, and islet morphology and function in...
  19. P

    Scientists Discover An Entirely New Biological System That Regulates Body Fat

    Scientists Discover an Entirely New Biological System That Regulates Body Fat
  20. P

    Creatine Fuels The Thermic Effect Of Feeding

    Creatine Fuels the Thermic Effect of Feeding. - PubMed - NCBI The current obesity epidemic has focused a great deal of attention on cellular pathways of energy expenditure. While a crucial part of this process is diet-induced thermogenesis, the underlying mechanisms have remained unexplained...
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