nitric oxide

  1. P

    Interstitial Sodium

    I highlighted some parts but other parts are interesting too https://www.sciencedirect.com/science/article/pii/S0735109714071782 Consequently, a large amount of Na+ is bound to GAGs, creating a microenvironment of hypertonic Na+concentration (19). However, the dense network exhibits a low...
    • paymanz
    • Thread
    • extracellular matrix glycoproteins glycosaminoglycans interstitial fluid lymphatic nitric oxide salt sodium vasopressin
    • Replies: 4
    • Forum: Articles & Scientific Studies
  2. haidut

    Breaking News: Viagra Given To Pregnant Women Is Lethal For The Babies

    As horrifying as it sounds, prescribing NO-boosting drugs to pregnant women is apparently perfectly acceptable in the search of more profit. The doctors probably got misled by the common practice in NICU of giving babies with pulmonary hypertension (or other breathing problems) an inhalation...
    • haidut
    • Thread
    • babies fetus lethal lung damage lung disease nitric oxide no pah poison pregnancy pregnant pulmonary arterial hypertension pulmonary fibrosis sildenafil toxic unborn viagra
    • Replies: 4
    • Forum: Scientific Studies
  3. haidut

    Dietary Nitrates Can Cause Mania After Just Two Weeks Of Consumption

    As many forum users already know dietary nitrates are an effective precursor to nitric oxide (NO). NO has been reliably linked to mania in humans, and mania is a known side effect of drugslike Viagra or nitroglycerin, but so far the official claim is that dietary nitrate intake does not cause...
    • haidut
    • Thread
    • diet humans mania mental health mental illness microbiome nitrate nitrates nitric oxide no
    • Replies: 41
    • Forum: Scientific Studies
  4. ddjd

    Nitric Oxide Isoforms - Information Needed!

    If you have any conflicting or supporting studies or information perhaps you could contribute! Aspirin (lowers ALL - eNOS, iNOS, nNOS conflicting - possibly raises eNOS) Arginine (raises eNOS, nNOS, iNOS) Agmatine (raises eNOS lowers nNOS, iNOS) Caffeine (lowers eNOS iNOS? nNOS?) Iodine...
  5. ddjd

    Taurine Increases Nitric Oxide

    Not very Peaty after all... Here's some studies: "taurine caused elevated concentration of 3-NT and NOx" Effects of taurine on nitric oxide and 3-nitrotyrosine levels in spleen during endotoxemia. - PubMed - NCBI "The results showed that taurine increasedserum levels of nitric oxide and...
  6. haidut

    Schizophrenia Treatment Could Be As Simple As Reducing Ammonia

    I posted a number of studies on Ceylon cinnamon and its metabolite sodium benzoate, showing their benefit in Parkinson disease, depression and anxiety. While all of those studies were on animal models, the toxicity of ammonia in the brain is undisputed and its role in all of these disease has...
    • haidut
    • Thread
    • ammonia ceylon cinnamon nitric oxide psychosis schizophrenia serine sodium benzoate treatment-resistant
    • Replies: 44
    • Forum: Scientific Studies
  7. haidut

    Methylene Blue Is A Potent Anti-inflammatory, With Possibly The Broadest Spectrum

    Some bold statements in this study, which combined both in vitro and in vivo models. The HED for methylene blue (MB) was just 0.15mg/kg, which is in the range of 10mg-15mg doses that showed great effectiveness in treating mental disorders like depression and psychosis. As you can see from the...
    • haidut
    • Thread
    • anti-inflammatory endotoxin inflammation lps metabolism methylene blue mitochondria mitochondrial respiration nitric oxide
    • Replies: 17
    • Forum: Scientific Studies
  8. haidut

    Plain (unmodified) Adamantane Is A Powerful Inhibitor Of NO Synthesis

    Many people on the forum are familiar with the beneficial properties of adamantane and its derivatives. However, most of the research conducted on the beneficial effects of these chemicals has been with adamantane derivatives such as amantadine, memantine, rimantadine, bromantane, etc. When we...
    • haidut
    • Thread
    • adamantane endotoxin inhibitor inos lps nitric oxide no synthesis
    • Replies: 11
    • Forum: Scientific Studies
  9. haidut

    Glycine May Protect From Heart Disease In Women

    The study looked at carriers of a specific variant of the gene CPS1 and the control this gene exerts over specific metabolites. Carriers of this gene variant had significantly increased glycine levels in the blood and lower levels of urea cycle metabolites, especially citrulline (which is a...
    • haidut
    • Thread
    • citrulline cps1 cvd females genes glycine heart disease nitric oxide women
    • Replies: 1
    • Forum: Scientific Studies
  10. haidut

    Nitrates / Nitrites Inhibit Androgen Synthesis By Raising NO

    Ray had a separate newsletter and a radio show on the dangers of NO precursors like dietary nitrates / nitrites and supplements like arginine. It is a bit ironic that quite a few bodybuilders out there pay a lot of money for the so-called NO boosters and in reality get the exact opposite effect...
    • haidut
    • Thread
    • androgen synthesis inhibition nitrates nitric oxide nitrites steroidogenesis study
    • Replies: 17
    • Forum: Scientific Studies
  11. raypeatclips

    Caffeine Decreases Nitric Oxide (NO) , Cox-2 Inhibitor

    Didn't see this posted and is a fairly new study. Also, does anyone any ideas how this relates to endotoxin? I am quite new at looking at studies. Caffeine prevents LPS-induced inflammatory responses in RAW264.7 cells and zebrafish. - PubMed - NCBI " Caffeine decreased the LPS-induced...
  12. haidut

    Nitrix Oxide (NO) Is A Likely Cause Of Migraines

    The good thing about this study is that it finally makes the connection between the known neurotoxin NO and the pathology of migraines. The bad thing about this study is that it still refers to NO as a heart-protective chemical and it also tries to blame the elevated levels of NO on specific gut...
    • haidut
    • Thread
    • endotoxin gut flora microbiome migraine nitrates nitric oxide study
    • Replies: 54
    • Forum: Scientific Studies
  13. P

    L-theanine Inhibits Nitric Oxide Production In Brain

    http://www.ncbi.nlm.nih.gov/pubmed/26957301 L-theanine is unique amino acid which readily crosses blood brain barrier and possesses neuroprotective potential against neurodegenerative disorders including Huntington disease (HD). HD is characterized by selective loss of GABAergic medium spiny...
  14. S

    Modern Anesthetic Theory Admits It's Not All About Lock & Key

    But still Ray Peat wouldn't like this too much. In fact if you keep reading the wikipedia it goes back to proteins (Ray Peat, Gilbert Ling, Stuart Hameroff, etc.): This aspect is also of relevance to Ray Peat: General anesthetics inhibit cytochrome P450 monooxygenases and arachidonic acid...
  15. P

    Nitric Oxide Synthase In Diabetic Rat Testicular Tissue And The Effects Of Pentoxifylline Therapy

    Nitric oxide synthase in diabetic rat testicular tissue and the effects of pentoxifylline therapy. - PubMed - NCBI Abstract Diabetes is known to be associated with erectile dysfunction, retrograde ejaculation, level of testicular hormone, and a decrease in semen quality, respectively. In this...
  16. P

    Phosphodiesterase Inhibitors Pentoxifylline And Rolipram Suppress Macrophage Activation & Nitric Oxi

    The phosphodiesterase inhibitors pentoxifylline and rolipram suppress macrophage activation and nitric oxide production in vitro and in vivo. - PubMed - NCBI Abstract We studied the effects of the phosphodiesterase inhibitors pentoxifylline (PTX) and rolipram (ROL) on nitric oxide (NO)...
    • paymanz
    • Thread
    • autoimmune disease inflammation nitric oxide pentoxifylline study
    • Replies: 0
    • Forum: Scientific Studies
  17. Koveras

    Serotonin Can Be Metabolized To Nitric Oxide

    May explain one of the mechanisms of serotonin's inflammatory effect in the brain, gut, and elsewhere. 5-Hydroxytryptamine is biotransformed by CYP2C9, 2C19 and 2B6 to hydroxylamine, which is converted into nitric oxide. "There is circumstantial evidence suggesting that 5-hydroxytryptamine...
  18. P

    Effect Of Ginger Powder Supplementation On Nitric Oxide

    Effect of ginger powder supplementation on nitric oxide and C-reactive protein in elderly knee osteoarthritis patients: A 12-week double-blind randomized placebo-controlled clinical trial Abstract There is limited evidence that ginger (生薑 shēng jiāng) powder consumption can relieve pain and...
  19. P

    Dark Chocolate Increase Nitric Oxide

    Effect of dark chocolate on nitric oxide serum levels and blood pressure in prehypertension subjects. - PubMed - NCBI Abstract AIM: to investigate the effect of consumption of dark chocolate 30 g/day for fifteen days on Nitric oxide (NO) serum levels and blood pressure in male and female...
  20. K

    Theanine Promotes Nitric Oxide Production?

    I was wondering what you guys think of this study: L-theanine promotes nitric oxide production in endothelial cells through eNOS phosphorylation. - PubMed - NCBI I take quite some theanine daily, 200mg up to 1 gram a day. I like it, but I'm not sure if I shouldn't take it, if it promotes...
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