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neurosteroid

  1. haidut

    The Stereotypes About Testosterone (T) Are Likely Wrong

    Just a few days ago, a thread was posted on the forum about a (observational) study implying that high T leads males to cheating. Higher Testosterone Levels Are Associated With Unfaithful Behavior In Men I made another post several months ago suggesting that it is likely cortisol, and in...
  2. haidut

    The (in)famous Condition “chemo Brain” May Be Simply A State Of Low DHEA

    The condition known as “chemobrain” is notorious among cancer survivors and many other patients undergoing toxic interventions with chemotherapy and may affect up to 85% of cancer patients. It amounts to severe cognitive dysfunction, memory problems, and even personality changes that result in...
  3. haidut

    Pregnenolone Relieves Chronic Low Back Pain (human Study)

    After failing to find any effective treatments for the many ills that plague veterans, doctors are finally turning to older remedies successfully used back in the first half of the 20th century. Pregnenolone is one such remedy and I have been seeing more and more studies and ongoing trials with...
  4. DaveFoster

    Mirtazapine Elevates Neurosteroids, Lowers Others

    This study reflects the findings of forum member haidut and Ray, where antidepressants possess progesterone-like effects in the brain. Besides its benefits for hormonal health, mirtazapine seems to exert beneficial effects on the neuron. However, it lowers 3-beta...
  5. BigYellowLemon

    Effects Of Morphine Dependence And Withdrawal On Levels Of Neurosteroids In Rat Brain

    Effects of morphine dependence and withdrawal on levels of neurosteroids in rat brain. - PubMed - NCBI It's a rat study but I think the results are applicable to humans. "The chronic morphine administration (ip) resulted in a marked decrease in the brain concentrations of pregnenolone (PREG)...
  6. haidut

    5α-Dihydroprogesterone (5α-DHP) - Potent Role In Neurodegenerative Conditions

    While researching saturated steroids and their effects on the brain, I noticed a number of highly promosing studies demonstrating benefit of such steroid for a variety of neurodegenerative conditions such as MS, ALS, Alzheimer, Parkinson, etc. Ray has written extensively on the topic of...
  7. haidut

    5α-Dihydroprogesterone (5α-DHP) - The Primary Progestogen Neurosteroid

    It has been shown that progesterone rapidly metabolizes into more saturated metabolites such as 5α-Dihydroprogesterone (5α-DHP) and tetrahydroprogesterone (also known as allopregnanolone or Allo). The enzyme 5-AR is the one responsible for the saturation, just as it is responsible for the...
  8. haidut

    Androsterone - Liquid Androsterone For Lab/R&D

    EDIT: Since I keep getting questions about androsterone, here is Ray's response when asked about it: Ray Peat Email Advice Depository Discussion/Comment Thread "...I think it would be safe enough to try in treating cancer or brain degenerative diseases." Here is one reference that gives backing...
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