1. haidut

    Niacinamide May Fully Prevent Miscarriages And/or Birth Defects

    I posted recently about the drastic reduction (or even reversal) of pre-eclampsia in pregnant women who took a small dose of aspirin. Aspirin Can Treat Pre-eclampsia Up until that study on aspirin came out, pre-eclampsia was considered untreatable and when a woman develops it usually the only...
  2. P

    Vitamin B3/NAD Fully Prevents The Development Of Glaucoma In Mice And Halts Its Progression If Alrea

    Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice | Science "Oral administration of the NAD+ precursor nicotinamide (vitamin B3), and/or gene therapy (driving expression of Nmnat1, a key NAD+-producing enzyme), was protective both prophylactically and as an...
  3. haidut

    Optimal Dose Of Niacinamide For Stimulating Respiration

    As many of you know, the Wikipedia page has a warning not to take more than 3g daily as it may elevate liver enzymes. I traced the warning to a few studies with high dose niacinamide using 4g - 6g daily for conditions like HIV and arthritis. However, they did not provide an explanation on why...
  4. haidut

    Niacinamide Reverses / Cures Duchenne Muscular Dystrophy

    It is well known even in mainstream medical circles that autoimmune conditions are characterized by greatly reduced levels of NAD. I posted a few studies in the past showing that raising NAD levels through supplementation of niacinamide can help virtually any autoimmune condition. This study...
  5. P

    Taurine Increases NAD+

    Effect of dietary taurine supplementation on GSH and NAD(P)-redox status, lipid peroxidation, and energy metabolism in diabetic precataractous lens. - PubMed - NCBI Abstract PURPOSE: To evaluate changes in glutathione and NAD(P)-redox status, taurine and malondialdehyde (MDA) levels, glucose...
  6. P

    Methylene Blue Protection Against Hypoxic Injury In Primary Cultures Of Rat Hepatocyte Monolayers

    Methylene blue protection against hypoxic injury in primary cultures of rat hepatocyte monolayers. - PubMed - NCBI Mitochondrial respiration is inhibited in cells exposed to hypoxia, and the oxidation of NADH to NAD(+) is blocked. As a result, oxidation reactions requiring NAD(+) are blocked...
  7. haidut

    Recovering Steroidogenesis Inhibited By Alcohol And Drugs

    As many of you know, drugs like Finasteride are really bad not only because they cause a variety of CNS effects as a result of inhibiting 5-AR, but also because they systemically inhibit the entire steroid synthesis cascade. Toxins and alcohol do the same and currently there is no approved...
  8. haidut

    Niacinamide Fully Prevents Breast Cancer Metastasis

    In yet another winning day (as Trump likes to say) for niacinamide, this study shows that the metastatic process of breast cancer is controlled by the NAD/NADH ratio, and NAD precursors like niacinamide can be effective chemotherapeutic agents. The human equivalent dose was 3g - 3.5g daily for a...
  9. haidut

    Niacinamide Causes Dramatic Increase In Nad And Fall In Lactate

    The good things about this study is that it is human and as such the doses are directly relevant. Given that the patient had MELAS, the niacinamide dose used was on the high end but still quite reasonable and comparable to the human trials of niacinamide in Alzheimer disease and stroke. The...
  10. haidut

    Amazing Medicinal Properties Of Beta-lapachone (β-lapachone)

    This thread is similar to the one I created for emodin and in support of the Lapodin supplement I released. Lapodin: Lapodin - Dietary Supplement With Beta-lapachone And Emodin | Ray Peat Forum Emodin: Amazing Medicinal Properties Of Emodin | Ray Peat Forum The purpose of this thread is to...
  11. haidut

    Amazing Medicinal Properties Of Emodin

    This thread is similar to the one I created for beta-lapachone and in support of the Lapodin supplement I released. Lapodin: Beta-lapachone...
  12. P

    Caffeine: Neuroprotective Against Quinolinic Acid Induced Mitochondrial Dysfunction; Huntington's Abstract BACKGROUND: Chronic quinolinic acid (QA) lesions in rats closely resemble Huntington's disease like conditions. Oxidative stress and mitochondrial dysfunction have long been implicated in the neurotoxic effects of QA acting through...
  13. juanitacarlos

    NAD Anti-aging Trials In Mice

    Interesting article - this what haidut has been talking about recently.