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mufa

  1. Mauritio

    Activating FXR decreases PUFA in the liver

    Very interesting study showing that activating the Farnesoid X Receptor results in lower levels of MUFA and PUFA in the liver. (Farnesoid X receptor - Wikipedia) Lowers levels of MUFA are brought on by downregulating genes like SCD1. "Elevated expression levels of SCD1 is found to be...
  2. haidut

    Lipolysis preferentially releases PUFA from adipose tissue

    ...compared to SFA and/or MUFA. This topic is considered highly controversial in Peat-land, mostly because of the dearth of studies dealing with it. I must have received hundreds of emails at this point criticizing Peat's stance on this issue and claiming that there is no evidence for...
  3. haidut

    Stearic acid (SA) is an estrogen receptor antagonist

    Over the last year or so I stumbled upon a few studies claiming both SA (C18:0) and its methyl ester are capable of binding the estrogen receptors (ER) and modulate their transcription effects. However, those studies did not evaluate if SA acted as an agonist or antagonist on those receptors...
  4. miquelangeles

    Botanical fixed oils clustered according to their fatty acid composition and saturation SFA:MUFA:PUFA ratios

    From: The Enigma of Bioactivity and Toxicity of Botanical Oils for Skin Care @Mauritio bear fat is also mentioned
  5. Mauritio

    Why PUFA is bad: how high membrane polyunsaturation decreases longevity

    Why PUFA is bad: how high membrane polyunsaturation decreases longevity: This is probably one of the most interesting papers I've read in a long time . It goes into depth about the danger of PUFA and conncects the dots between PUFA ,membranes ,rate of living theory, life expectancy, and...
  6. haidut

    Dietary PUFA In Childhood Causes Diabetes And Irreversible (male) Infertility

    A great study, which corroborates the discussion in another recent post of mine on PUFA's role in infertility and insulin-resistance / diabetes. However, the study below found that the infertility caused by dietary PUFA exposure were NOT reversible upon discontinuation of the high-fat (both PUFA...
  7. haidut

    Melanoma Defined By Increased Fatty Acid Synthesis And Unsaturation

    Yet another study implicating dysregulated fatty acid, instead of glucose, metabolism in cancer cells. Namely, the expression and activity of the enzyme fatty acid synthase (FASN) is increased in melanoma cells. Another interesting finding of the study is the increased unsaturation of the...
  8. haidut

    SFA / MUFA Are Preferentially Oxidized, While PUFA Are Stored/accumulated

    Just a quick post in response to some of the hate mail I keep getting on a daily basis in regards to the body's discriminatory treatment of various fat types. According to various proponents of keto diets, fasting, etc the organism has no preference for one type of fat or another in terms of...
  9. haidut

    Cholesterol And SFA Are Anabolic; PUFA/MUFA Akin To Chemical Castration

    A pair of interesting study and a commentary in the highly respected Journals of Gerontology. Namely, higher cholesterol intake is associated with much higher lean muscle mass accrual as a result of weight lifting. Interestingly, higher protein intake was not. Even more interestingly, and much...
  10. P

    Different Effect Of MUFA Vs SFA On Tissues PUFA Content

    Comparative effects of high oleic acid vs high mixed saturated fatty acid obesogenic diets upon PUFA metabolism in mice. - PubMed - NCBI Abstract Emerging evidence indicates that the fatty acid composition of obesogenic diets influences physiologic outcomes. There are scant data regarding how...
  11. haidut

    PUFA And MUFA Are Strong Inhibitors Of 5-AR, Saturated Fatty Acids Are Not

    I have posted quite a few studies showing the effects of various fatty acids on estrogen, androgen and glucocorticoid synthesis. This study shows that both PUFA and MUFA are strong inhbitors of 5-AR, with PUFA being the more potent inhibitors and inhibition potency being strongly dependent on...
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