mitochondria

  1. haidut

    Inosine Powerfully Stimulates Mitochondriogenesis, Oxidative Metabolism & Cell Differentiation

    Yet another absolutely great study on inosine. It shows that not only can inosine replenish ATP (as shown in the previous studies I posted) but it can inhibit excessive glycolysis, lower lactate, and dramatically improve oxidative metabolism - effects which are key driver of cell differentiation...
    • haidut
    • Thread
    • atp cancer differentiation glycolysis inosine lactate ldh mitochondria mitochondrial respiration mitochondriogenesis oxidative metabolism respiration
    • Replies: 27
    • Forum: Scientific Studies
  2. haidut

    Methylene Blue Is A Potent Anti-inflammatory, With Possibly The Broadest Spectrum

    Some bold statements in this study, which combined both in vitro and in vivo models. The HED for methylene blue (MB) was just 0.15mg/kg, which is in the range of 10mg-15mg doses that showed great effectiveness in treating mental disorders like depression and psychosis. As you can see from the...
    • haidut
    • Thread
    • anti-inflammatory endotoxin inflammation lps metabolism methylene blue mitochondria mitochondrial respiration nitric oxide
    • Replies: 17
    • Forum: Scientific Studies
  3. haidut

    Niacinamide And Doxycycline May Treat Alzheimer Disease (AD)

    This study is yet another one that shows benefit of raising NAD levels for treating neurodegenerative conditions like AD. There were a few older studies around 2003, which were also done on mice and as a result of those studies a human clinical trial with 3g niacinamide daily (a dose that...
    • haidut
    • Thread
    • alzheimer's cure doxycycline metabolic mitochondria mitochondrial dysfunction nad niacinamide parkinson reverse treat
    • Replies: 7
    • Forum: Scientific Studies
  4. haidut

    Palmitic Acid (palmitate) Strongly Increases Oxidative Metabolism

    This is yet another thread as a follow up on the recent posts about plamitic acid inhibiting fatty acid oxidation and having therapeutic roles in cancer, diabetes and all other disease characterized by elevated/abnormal fatty acid metabolism. Palmitic Acid (palmitate) Is A Fatty Acid Oxidation...
    • haidut
    • Thread
    • increase mitochondria oxidative metabolism oxygen consumption palmitate palmitic acid respiration stimulate
    • Replies: 40
    • Forum: Scientific Studies
  5. haidut

    Exposure To EMF May Cause ALS

    I am posting this not so much because the link is strong but because the official message is that EMF is "completely benign" and cannot cause any disease because there is no known mechanism of action for it. That is of course a lie, and I posted a Q&A on Reddit that occurred a few years ago in...
    • haidut
    • Thread
    • als causative electric shock electrical fields electromagnetic radiation emf metabolism mitochondria neurodegenerative
    • Replies: 19
    • Forum: Scientific Studies
  6. haidut

    Lifespan / Longevity May Be Tied To Environmental Conditions

    While I do not agree with the main assertions of the author on "rate of living" theory, he does make a few very important points, including the vital importance of mitochondria and metabolism for evolution and lifespan. Also, he lists a few examples of species where lifespan doubled simply...
    • haidut
    • Thread
    • adversity evolution lifespan longevity metabolic rate metabolism mitochondria ros
    • Replies: 0
    • Forum: Scientific Studies
  7. zarrin77

    Study Shows Aspirin Inhibits Mitochondrial Complex I

    So I know Peat says that aspirin increases oxidative glucose metabolism, however this study (and if you read the full text, other studies as well) shows that all NSAIDs, including aspirin, inhibits mitochondrial complexes (especially complex I). This study shows that quercetin can be used to...
  8. haidut

    Androsterone Is A Potent Agonist / Activator Of The Farnesoid X Receptor (FXR)

    The so-called Farnesoid X Receptor (FXR) is a very interesting nuclear receptor inside the cell. It has a multitude of functions, but one of the main functions includes sensing and controlling the levels and synthesis of bile acids. As I mentioned in a few other posts, nuclear receptors...
    • haidut
    • Thread
    • activator agonist androsterone bile acid farnesoid fxr liver metabolism mitochondria study
    • Replies: 42
    • Forum: Scientific Studies
  9. P

    Some Pentoxifylline Studies

    Pentoxifylline Reverses Oxidative Mitochondrial Defect in Claudicating Skeletal Muscle The effect of pentoxifylline on filterability of normal red blood cells and their adhesiveness to cultured endothelial cells - Springer Pentoxifylline Neuroprotective Effects Are Possibly Related to Its...
    • paymanz
    • Thread
    • antiinflammatory cardiac diabetes dopaminergic jnk mitochondria mitochondrial dysfunction neuroprotective oxidative metabolism parkinson's pentoxifylline study tnf
    • Replies: 8
    • Forum: Scientific Studies
  10. haidut

    MitoLipin - Liquid Saturated Phosphatidylcholine (PC) Mix

    Ray has written extensively about the mitochondria and its crucial role in health. The structure and contents of the mitochondria undergo extensive change as part of the aging process and one of the most important constituents of mitochondria is the lipid cardiolipin (CL). CL is crucial for the...
    • haidut
    • Thread
    • cardiolipin complex iii complex iv complex v cytochrome dipalmitoylphosphatidylcholine distearoylphosphatidylcholine dppc dspc electron transport chain mitochondria mitolipin oxidase oxidative metabolism phosphatidylcholine phospholipid
    • Replies: 732
    • Forum: IdeaLabs
  11. S

    Acknowledging Selection At Sub-organismal Levels Resolves Controversy On Pro-cooperation Mechanisms

    Acknowledging selection at sub-organismal levels resolves controversy on pro-cooperation mechanisms
  12. P

    Mitochondrial Nutrients Stimulate Performance And Mitochondrial Biogenesis In Exhaustively Exercised

    Mitochondrial nutrients stimulate performance and mitochondrial biogenesis in exhaustively exercised rats. - PubMed - NCBI Abstract The aim of this study was to investigate the effects of a combination of nutrients on physical performance, oxidative stress and mitochondrial biogenesis in...
    • paymanz
    • Thread
    • coq10 creatine mitochondria mitochondriogenesis niacinamide study taurine vitamin b2 vitamin b6 vitamin b7
    • Replies: 1
    • Forum: Articles & Scientific Studies
  13. haidut

    Breakthrough In Understanding (and Potentially Reversing) Aging

    This studies only looked at skin cells but the mechanism is apparently present in all tissue cells and as such the scientists think that therapies can be developed not only for reversing skin aging but also systemic aging. Unsurprisingly, skin cell aging was found to be due to decline of...
    • haidut
    • Thread
    • aging decline dehydrogenase mitochondria succinate succinic
    • Replies: 8
    • Forum: Scientific Studies
  14. haidut

    Blood Sugar Is Controlled Mostly By The Brain, Not Pancreas

    Ray wrote in one of his articles that pancreatic insulin is responsible for no more than 20% of glycemic control. While he mentioned potassium as the major factor, he also said that it is the brain that ultimately controls the levels of sugar in the blood. This study from Yale seems to confirm...
    • haidut
    • Thread
    • biogenesis blood brain control insulin mitochondria pancreas sugar uncoupling
    • Replies: 8
    • Forum: Scientific Studies
  15. haidut

    Aging In Cells Is Driven By Mitochondria

    The process of aging is complex and according to mainstream science comes down to genes. Over the last few decades some scientists have discovered that genes probably do not play a major role but rather that aging comes down to processes in the mitochondria. However, until now, there had been no...
  16. A

    Increased Uncoupling Protein 1 In Brown Adipose Tissue Of Mice Fed A Ketone Ester Diet

    http://www.ncbi.nlm.nih.gov/pubmed/22362892 "The KE group exhibited 14% greater resting energy expenditure, but the total energy expenditure measured over a 24-h period or body weights was not different. The quantitative insulin-sensitivity check index was 73% higher in the KE group. These...
  17. L

    Mitochondria Affect Stress Responses

    Mitochondria affect stress responses Cell's powerhouse plays role in mind-body interactions, with long-term health effects Wallace postulates that the current study indicates that an important reason for our limited progress in understanding the genetic and biologic basis of psychology is our...
    • lollipop
    • Thread
    • article health mind mitochondria stress response
    • Replies: 0
    • Forum: Mind, Sleep, Stress
  18. P

    Methylene Blue Delays Cellular Senescence And Enhances Key Mitochondrial Biochemical Pathways

    www.ncbi.nlm.nih.gov/pubmed/17928358 Abstract Methylene blue (MB) has been used clinically for about a century to treat numerous ailments. We show that MB and other diaminophenothiazines extend the life span of human IMR90 fibroblasts in tissue culture by >20 population doubling (PDLs). MB...
    • paymanz
    • Thread
    • aging cytochrome c fibroblast methylene blue mitochondria study
    • Replies: 1
    • Forum: Scientific Studies
  19. haidut

    Aging In Human Mitochondria Fully Reversed By Glycine

    In the latest confirmation of Ray's views, this study demonstrates that mitochondrial aging (and maybe the entire cell) is NOT controlled by genetic factors and mutations but by epigenetics. I personally think the days of the fraudulent "Hayflick limit" are numbered. Since it is epigenetically...
  20. haidut

    Aspirin Comparable To DNP As Mitochondrial Uncoupler

    This image is from the study I posted on the effects of aspirin on GI tract. As you can see from the attached image, aspirin increased mitochondrial respiration by 300% while DNP increased it by 400%. However, the authors stated that this concentration of DNP is not safe and in reality most...
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