mitochondria

  1. haidut

    Mitochondrial Damage And Fatty Acid Buildup, Not Glucose, May Drive Diabetes

    Finally some common sense is coming out of mainstream medicine. The study below demonstrates that it is the buildup of fatty acid metabolites and mitochondrial damage that drives the chronic inflammation now known to be a major causative factor for diabetes II (T2DM), as well as virtually all...
  2. haidut

    MS Tied To Glucose Deficiency Due To Endotoxin And Fat, Extra Glucose May Treat It

    Just a few days ago I posted the groundbreaking study on metabolic derangement in ALS - i.e. it is a diseased characterized by increased FAO, which wastes glucose. Simply increasing dietary glucose was able to greatly restrain the pathology...
  3. Mauritio

    Anxiety / Mental Illness Caused By Mitochondria

    Role of mitochondrial uncoupling protein-2 (UCP2) in higher brain functions, neuronal plasticity and network oscillation This is another study along the lines of what @haidut has been posting here for the last years: mental Illnesses are a metabolic problem, start in the mitochondria and (what...
  4. Mauritio

    Uncoupling Increases Life Span And Generates More Mitochondria

    Dont know if this study has been posted before ,one way or another it is worth a read! Uncoupling protein-2 and the potential link between metabolism and longevity. The discovery of novel uncoupling proteins (UCP2 and UCP3) over 10 years ago heralded a new era of research in mitochondrial...
  5. haidut

    Osteoporosis Is Caused By Mitochondrial Dysfunction Driven By Nitric Oxide (NO)

    Let’s repeat the mantra one more time – structure and function cannot be separated, they are mutually dependent at every level of reality/life. As such, it is little surprise (to us) that a structural disorder like osteoporosis may be caused by a deficiency in energy production. Yet, despite...
  6. haidut

    Mitochondria (energy) As The Main Driver Of Health, Intelligence, And Aging

    We are finally starting to see Peat enter the mainstream and article like the one below are calling for a complete review of what we know about health and aging and how intelligence is tied to them. As the authors says, or actually borrows from Peat, there is solid evidence that mitochondrial...
  7. haidut

    Damaged Mitochondria And Endotoxin (LPS) Drive Chronic Inflammation

    Chronic, low-grade inflammation has now been recognized as the main cause behind a number of chronic degenerative conditions including CVD, diabetes, cancer, Alzheimer, Parkinson, etc. Mainstream medicine claims that the cause of this chronic low-grade inflammatory reaction is unknown, despite...
  8. haidut

    Chronic Stress / Defeat Causes Mental Illness By Damaging Mitochondria

    Yet another study demonstrating that mental illness has little to do with genetics, and is likely entirely due to energetic deficiency caused by environmental stress. This energetic deficiency is caused by mitochondrial damage caused by said stress. Keeping lipolysis and/or PUFA intake low can...
  9. haidut

    Heat Therapy Restores Mitochondrial Function In Human Muscles

    A really cool study, and I think the reported effects would have been even more impressive if instead of diathermy the scientists used a simple incandescent red bulb to both heat the muscle and expose it to red light. Maybe somebody can email them and suggest this as a follow up study... Heat...
  10. haidut

    Children Inherit Mitochondrial DNA From Their Fathers Too

    One of the unquestionable dogmas of genetics (up until) today is that all mitochondrial DNA of a child is inherited strictly from the mother. This firmly entrenched belief is taught as an immutable truth in medical schools and is used to justify extensive genealogical genomic tests down the...
  11. haidut

    Mitochondria Likely Determine Disease Risk, Not The Main Genome / DNA

    As I mentioned several times on Danny's podcasts, the genetic approach to curing disease has not really produced much for the last 80 years so little by little the industry is shifting its focus on metabolism. However, that shift won't happen overtly by admitting metabolism is key. Rather, it...
  12. nigma

    Do Our Mitochondria Run At 50 Degrees C?

    https://phys.org/news/2018-01-mitochondria-degrees.html Not sure if this has been covered yet, didn't find anything after a quick search of the forum. This is really interesting as it fits with the ideas of Ray Peat, Gilbert Ling and Gerald Pollack. Body temp of 37 C is created by what is...
  13. haidut

    Stress As The Underlying Cause Behind ALL Chronic Diseases

    One of the more controversial of Ray's statements is that chronic stress is the underlying cause of many/most chronic conditions, especially autoimmune ones. In several of his articles he describes the role tissue damage under the influence of cortisol and estrogen play in creating an immune...
  14. haidut

    Bile Acid Stimulates Mitochondrial Function, Could Treat Parkinson And Alzheimer's

    I posted a few studied some time ago showing that bile acids increase metabolism but stimulating the synthesis of T3. This increase in metabolism is perhaps the main mechanism behind the ability of "obesity surgery" to provide long-term benefits for the people who undergo the procedure. Aside...
  15. P

    Roles Of Interstitial Fluid PH In Diabetes Mellitus: Glycolysis And Mitochondrial Function

    Roles of interstitial fluid pH in diabetes mellitus: Glycolysis and mitochondrial function
  16. haidut

    Serotonin Causes Bipolar Disorder (through Mitochondrial Dysfunction)

    Yet another nail in the coffin of the "happiness hormone", which may end up being one of the biggest scientific frauds of the 20th century, rivaling the one about estrogen being the "female" hormone. It has been known for a long time that both lithium and methylene blue, both of which are...
  17. haidut

    Niacinamide May Be A Viable Treatment For Parkinson Disease (PD)

    It looks like the pharma industry is experiencing a resurgence in the search for metabolic therapies with patented chemicals. There must have been at least 50 different studies in 2017 alone with the NAD precursor nicotinamide riboside (NR) for conditions ranging from cancer, to glaucoma, to...
  18. haidut

    New Human Trial With An NAD Precursor

    I just wanted to post this here, as it seems interest in raising NAD is high among pharma companies. While nicotinamide riboside is the most popular precursor used in the Western world, nicotinamide mononucleotide (NMN) is another one that has been used clinically. This clinical trial below...
  19. haidut

    Estrogen As The Main Cause Of Cancer And Its Progression

    I think many of the forum users here know about the infamous study that generated a lot of controversy on "scientific" forums like Reddit. It basically showed that the Warburg Effect (overproduction of lactate) is not just an effect but a direct cause of cancer. So, as the top rated comment on...
  20. haidut

    Stearic Acid Increases Mitochondrial Function, May Treat Parkinson Disease (PD)

    I posted recently about the ability of dietary stearic acid to reduce abdominal fat accumulation by more than 70%. This study provides some insight as to what the mechanism of action behind that anti-obesity effect may be. The study below found that when stearic acid was fed at a dose of 10% of...
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