mitochondria

  1. cs3000

    Profound linear effect of Hesperidin in diabetes & ulcer / wound healing (& protection against toxic heavy metals) (+youth restoration)

    Hesperidin enhances angiogenesis via modulating expression of growth and inflammatory factor in diabetic foot ulcer in rats Rats with induced diabetes & ulcers were given Hesperidin orally, at does 10mg/kg - 80mg/kg . Group I = non-diabetic non-wounded controls Group II = non-diabetic wounded...
    • cs3000
    • Thread
    • diabetes heavy metals hesperidin mitochondria toxic metals ulcer wound healing
    • Replies: 12
    • Forum: Scientific Studies
  2. haidut

    Mitochondrial dysfunction is a major cause of cardiovascular disease (CVD)

    At a first glance, mitochondrial dysfunction (a "functional" problem) has little in common with the build-up of plaque on arterial walls (a "structural" problem). However, as my readers know quite well, structure and function cannot be separated and a functional pathology is perfectly capable...
    • haidut
    • Thread
    • cvd heart disease inflammation metabolism mitochondria plaque ros
    • Replies: 7
    • Forum: Scientific Studies
  3. haidut

    Neuron/brain growth depends on metabolism (OXPHOS)

    As many of my readers know, the mainstream medical dogma is that the number of neurons in the human grain increases until early adulthood, after which it stops completely. Thus, medicine views the adult human brain as having a fixed number of neurons and any damage to them or complete loss of...
    • haidut
    • Thread
    • brain differentiation growth metabolism mitochondria neuron oxphos
    • Replies: 1
    • Forum: Scientific Studies
  4. haidut

    Major depression likely driven by mitochondrial deterioration/dysfunction

    This the latest study demonstrating that not only are various chronic diseases and aging essentially the same process, but that this process is fundamentally bioenergetic in nature. Namely, dysfunctional mitochondria, leading to low OXPHOS, is the direct cause of many physiological and "mental"...
    • haidut
    • Thread
    • aging bioenergetics depression gdf-15 mitochondria oxphos senescence senolytic
    • Replies: 4
    • Forum: Scientific Studies
  5. haidut

    Harvard Psychiatrist: All Mental Disease is Metabolic/Bioenergetic Disease

    It is always nice to see mainstream medicine plagiarize from Dr. Peat attempt to right its course after decades-long mistakes. While the genetic dogma still rules supreme in medicine's attitude towards most "physical" diseases, the utter failure of the "serotonin hypothesis" and its dear...
    • haidut
    • Thread
    • diet energy mental disease mental health metabolism mitochondria oxphos stress
    • Replies: 32
    • Forum: Scientific Studies
  6. haidut

    Diabetes, Alzheimer's, cancer are bioenergetic diseases; PUFA may be the cause

    The bad news for PUFA (in this case linoleic acid) just keep piling on. At this point, there is hardly a chronic condition out there that has not been linked to elevated PUFA and/or their peroxidation products. The first study below makes the argument that PUFA peroxidation byproducts (created...
    • haidut
    • Thread
    • 4-hydroxynonenal alzheimer cancer diabetes mitochondria oxphos pufa ros
    • Replies: 1
    • Forum: Scientific Studies
  7. haidut

    Impaired OXPHOS by high ketones drives heart failure

    Just a few weeks after my post on how excessive fatty acid oxidation (FAO) drives cancer, below is another great new study, which corroborates once again the hypothesis that excessive FAO (and/or fatty acid supply into the mitochondria of the cell) result in impaired OXPHOS and organ damage...
    • haidut
    • Thread
    • fao fatty acid oxidation heart failure ketone krebs mitochondria oxphos succinate
    • Replies: 4
    • Forum: Scientific Studies
  8. haidut

    Disrupting mitochondrial function can cause severe anemia

    Most doctors consider anemia mostly an iron-related issue, despite the fact that iron supplementation often fails to correct the condition, even in people with true iron deficiency anemia (e.g. low iron saturation index, low ferritin, high transferin). The role of bioenergetics is rarely...
    • haidut
    • Thread
    • anemia hematopoiesis metabolism mitochondria oxphos rbc thyroid
    • Replies: 1
    • Forum: Scientific Studies
  9. haidut

    PUFA damages mitochondria, blocks mitophagy, leads to heart damage

    I can't get access to the full study text, so the comments I have here are based only on the abstract of the study below. However, even just the abstract is sufficient to demonstrate once again the dangers of PUFA. Despite the study not calling PUFA out directly, it does mention lard as the food...
    • haidut
    • Thread
    • debris fibrosis heart inflammation lard mitochondria mitophagy pufa
    • Replies: 2
    • Forum: Scientific Studies
  10. haidut

    Pregnenolone (P5) improves recovery from stroke

    One of the few direct studies with P5 in-vivo, though that may be changing as I noticed the rate of articles on P5 has been rising over the last 5-6 years. This study used four (4) administrations of P5, at a HED of just 0.3mg/kg, 1, 6, 12, and 18 hours after the (ischemic) stroke was caused...
    • haidut
    • Thread
    • cognition etc ischemia mitochondria p5 pregnenolone strength stroke
    • Replies: 1
    • Forum: Scientific Studies
  11. haidut

    Mitochondrial debris (from stress/injury) causes "autoimmune" disease

    After dancing around the issue for the last 10+ years, it looks like medicine is finally ready to admit the obvious. Namely, cellular (and more specifically, mitochondrial) debris created by stress/injury and dumped into the bloodstream causes the (in)famous "flares" that define virtually all...
    • haidut
    • Thread
    • autoimmune catabolism cellular debris inflammation mitochondria mtdna
    • Replies: 27
    • Forum: Scientific Studies
  12. Sefton10

    Mitochondrial Calcium: Effects of Its Imbalance in Disease

    Mitochondrial Calcium: Effects of Its Imbalance in Disease https://www.mdpi.com/2076-3921/11/5/801/htm
    • Sefton10
    • Thread
    • alzheimer alzheimer disease atp calcium huntington's mitochondria parkinson's disease
    • Replies: 3
    • Forum: Calcium
  13. haidut

    Stem cells availability, and their differentiation, depend on metabolism

    Once again, the master controller role metabolism plays in human life is revealed in yet another experiment. The study below demonstrated that the degree of cell "stemness", as well as its differentiation into a specific organ/tissue depends entirely on the metabolic rate of the cell, and thus...
    • haidut
    • Thread
    • cancer differentiation metabolism mitochondria mitosis morphogenesis oxphos stem cell
    • Replies: 1
    • Forum: Scientific Studies
  14. haidut

    Epilepsy/seizures caused by energetic deficit leading to calcium overload

    Yet another study demonstrating that not only is a chronic, "incurable" disease of unknown origin treatable but that its main cause is energetic/metabolic and linked to impaired glucose metabolism. Specifically, the study demonstrated that impaired pyruvate transport into the mitochondria is...
    • haidut
    • Thread
    • calcium epilepsy glucose ketogenic mitochondria oxphos pyruvate seizure
    • Replies: 3
    • Forum: Scientific Studies
  15. haidut

    Aging and disease are the same process, driven by low metabolism

    I am posting about this mostly due to its "told you so" factor - i.e. more and more professionals in the medical and research fields are starting to realize that the super-specialized approach to treating chronic diseases has not produced any substantial results. In addition, the correlation...
  16. haidut

    "Reductive" stress harms cells, mitochondria protect by increasing metabolism

    Finally a study that provide me with some "ammo" during my arguments with people I know who work in the medical profession. A common topic in such arguments is the mainstream medical idea that it is almost impossible to have too much antioxidants and too little oxidation. In fact, to many...
    • haidut
    • Thread
    • metabolism mitochondria oxidation redox reduction stress sulfhydryl thiol
    • Replies: 24
    • Forum: Scientific Studies
  17. haidut

    Cancer cells deprive immune cells of energy by devouring their mitochondria

    In a description that could be a good plot for a horror-movie, the study below demonstrates that the immune failure often seen in cancer is, again, bioenergetic in origin. More specifically, the immune system cells are getting literally the energy (i.e. mitochondria) sucked out of them by cancer...
    • haidut
    • Thread
    • cancer cell endotoxin estrogen immune invadopodia lps mitochondria oxphos phagocytosis
    • Replies: 1
    • Forum: Scientific Studies
  18. haidut

    Uncoupling metabolism/OXPHOS may treat inflammatory conditions

    In several of his articles and interviews, Peat mentioned that one of the reliable signs/symptoms of low metabolism is the presence of low-grade chronic inflammation. Basically, the cell is stuck into a constant (and futile) repair process as it cannot complete it properly after discovering the...
    • haidut
    • Thread
    • atpase inflammation metabolism mitochondria oxphos ros uncoupling
    • Replies: 4
    • Forum: Scientific Studies
  19. haidut

    Restoring oxidative metabolism has curative effects on cancer (leukemia)

    A great study, which directly demonstrates not only the OXPHOS deficiency characteristic of all "cancer" cells, but also proving that restoration of OXPHOS is highly therapeutic (and likely curative) for leukemia. Just as importantly, the study demonstrates that cancer cells have, in fact...
  20. haidut

    Cartilage/bone health depends on oxidative metabolism

    A good study that demonstrates yet another "structural" aspect of health - the strength and growth or our cartilage/bones - is heavily dependent on proper mitochondrial function. As such, even minor disruptions of oxidative metabolism can lead to long-term deformations in bone/cartilage, which...
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