1. haidut

    Blocking serotonin (5-HT) stops withdrawal symptoms in addicts

    The role of 5-HT and other stress mediators such as cortisol, adrenaline, estrogen, prolactin, histamine, etc has long been suspected in both "addiction" and the withdrawal symptoms seen in virtually all "addicts" upon abstinence. The anti-adrenaline (and anti-cortisol) drug clonidine has been...
  2. F

    Mirtazapine Sources? (And overwhelming positive experience)

    Hi all, I have been taking mirtazapine for about a week now, at a dose of approximately 2mg nightly. (via the "Mirataz" feline formulation, lol) I struggle with excess cortisol/adrenaline and I find that this medication works for me in the same way as cyproheptadine, but with more mental...
  3. Jwicks1995

    Seroquel/Quetiapine - Cortisol/Anti-Seretonin

    I have Unipolar Depression, Anxiety & Major Gut issues. Mirtazapine seems to have failed due to the Noradrenergic profile having a negative effect on my extremely high anxiety. Cannot even handle 15mg it seems...I want to try Seroquel, I understand it affects 5HT1A & antagonizes various 5-HT...
  4. L

    How Do Cyproheptadine And Mirtazapine Induce Sleep And Increase Appetite?

    What are the main mechanisms for these effects? Is it the anti serotonin action, anti histamine, or both together? Or something else? @DaveFoster could you explain, in detail?
  5. L

    Risk Of Fibrosis With Serotonin Antagonists

    We know that drugs with the 5-ht2b agonist effect have been linked with fibrosis risk. Which of the serotonin antagonists are safe to use for long term in this regard? I have read that cyproheptadine, pizotifen, lisuride, metergoline, ritanserin, ketanserin are safe. Any more?
  6. DaveFoster

    Mirtazapine Increases T4-T3 Conversion, Possible Antidepressant Mechanism

    Dr. Peat has written about cortisol's ability to impair the liver's conversion of T4 to T3, and since elevated serotonin signals the ACTH to produce excess cortisol, it's no surprise that an anti-serotonin drug lowers cortisol and restores the endogenous conversion of T4 to T3. Those who have...
  7. DaveFoster

    Mirtazapine Elevates Neurosteroids, Lowers Others

    This study reflects the findings of forum member haidut and Ray, where antidepressants possess progesterone-like effects in the brain. Besides its benefits for hormonal health, mirtazapine seems to exert beneficial effects on the neuron. However, it lowers 3-beta...
  8. DaveFoster

    Mirtazapine Powerfully Lowers Cortisol

    Forum member haidut has posted many studies that anti-serotonin drugs lower cortisol, and here's some more evidence that the antidepressant mirtazapine dose the same. Mirtazapine has mixed serotenergic properties, but Ray thinks it might be useful in some situations. It's anti-serotonin and...
  9. DaveFoster

    Anti-Serotonin Drugs May Treat Fibromyalgia

    Effects of antidepressant mirtazapine on fibromyalgia symptoms. PURPOSE: Fibromyalgia syndrome (FS) is a form of non-articular rheumatism. The main criteria are the widespread musculoskeletal pain and tender points at multiple characteristic sites which are associated with several vegetative...
  10. DaveFoster

    Long-term Mirtazapine Administration Permanently Lowers Adrenaline

    Effects of long-term treatment with the alpha 2-adrenoceptor antagonist mirtazapine on 5-HT neurotransmission. Mirtazapine (ORG 3770, Remeron) is a nonselective alpha 2-adrenoceptor antagonist with antidepressant activity in major depression. The aim of the present study was to assess, using an...
  11. Kang


    OK first time poster. Patience please. I ran a search came up empty. I used to use Mirtazipine when I was low carb etc. but this is my first time since going Peat about 5 years ago. I just came back from driving 18 hours out of 36, 9 hours each end of an 18 hour work window with about 6 hours...
  12. DaveFoster

    Mirtazapine Experiences

    I've heard mirtazapine mentioned on this forum, and my psychiatrist has brought it up a couple times. It increases noradrenaline concentrations in the brain at higher dosages; haidut has mentioned the NE increases estrogen. Besides this, any experiences with depression/anxiety and general...
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