metabolism

  1. haidut

    Century-long metabolic decline, not less exercise and/or more eating, causing the obesity epidemic

    I did a few posts years ago on the alarming findings that the youngest generations are among the most physically active, consume the least amount of calories, yet are the most obese (on average) compared to previous generations going back to at least the 1950s. Those studies did not look at...
  2. mantq

    The Metabolic Effects of Dietary Salt Intake: High Salt intake Leads to Cardiovascular and Metabolic Changes

    Hey everyone! Found an interesting illustration regarding salt, thought many of you would find this rather interesting and perhaps useful :)
    • mantq
    • Thread
    • cardiovascular high salt intake metabolic changes metabolism salt
    • Replies: 1
    • Forum: Scientific Studies
  3. haidut

    Aspirin / eugenol can remove lipofuscin from cells

    One of the visible hallmarks of aging is the accumulation of so-called "age pigment" or "aging spots", commonly known in scientific circles as lipofuscin. The latter is a complex mix of peroxidized polyunsaturated fats (PUFA) and various metals (especially iron) that accumulates in cells with...
    • haidut
    • Thread
    • aging aspirin eugenol iron lipofuscin metabolism peroxidation pufa
    • Replies: 97
    • Forum: Scientific Studies
  4. haidut

    Metabolic rate may determine personality type and disease risk

    Very interesting study that links mitochondrial density/number (and as such, the metabolic rate) with personality types. Namely, people with fewer mitochondrial (i.e. hypometabolic) tend to have high levels of neuroticism, with the latter causally linked to a higher risk of a number of serious...
    • haidut
    • Thread
    • atp bioenergetics metabolism mitochondria neuroticism oxphos personality
    • Replies: 4
    • Forum: Scientific Studies
  5. haidut

    Restoring mitochondrial function may be sufficient to reverse aging

    The findings of the study may not sound very novel to my readers, however please keep in mind that the vast majority of anti-aging studies so far have only looked at slowing (not even stopping) aging. Actually reversing aging is the Holy Grail of gerontology, and to date very few studies have...
    • haidut
    • Thread
    • aging energy lifespan metabolism mitochondria oxphos polarization
    • Replies: 6
    • Forum: Scientific Studies
  6. Limon9

    The Mitochondrial Progesterone Receptor (PR-M) In Human Sperm

    Haidut has written threads elsewhere about the necessity of the CatSper for male fertility, a calcium channel activated by progestogens: Male Fertility Depends On Intensity Of (sperm) Metabolism ... but did you know it expresses the "mitochondrial progesterone receptor" Dr. Peat talked about...
  7. haidut

    The "cancer metabolism" drives aging in humans

    A truly monumental study, as it is perhaps the first one to demonstrate that "aging" in human cells is entirely under metabolic control. What can I say - Ray Peat right again! Unfortunately, the way the actual study has been worded has been, once again, criminally mis-represented by mainstream...
    • haidut
    • Thread
    • aging cancer glycolysis lifespan metabolism mitohondria oxphos
    • Replies: 18
    • Forum: Scientific Studies
  8. haidut

    Gel manicures lead to cell death, mitochondrial dysfunction and cancer

    Yet another common and "benign" cosmetic procedures has now been demonstrated to be actually quite dangerous. Prior studies have already demonstrated that hair dyes, makeup, botox, nail polish, and even essential oil therapy all have toxic side effects that in the long run can cause serious...
    • haidut
    • Thread
    • cancer manicure metabolism mitocchondria mutation nail radiation uv
    • Replies: 15
    • Forum: Scientific Studies
  9. cs3000

    Hesperetin restores youth in old rats - enhances lifespan ~8% up to ~14% when given late, restores mitochondria & metabolism, reverses heart damage

    Posting this part from a thread i wrote on Hesperidins beneficial effects on toxic metal protection, diabetes, wound healing etc Great study on the life promoting effects of hesperitin (the derivative of hesperidin found in orange juice): *Reverses effects of aging / restores youth...
    • cs3000
    • Thread
    • aging flavonoid heart hesperetin hesperidin life extension lifespan metabolism mitochondria mitochondrial dysfunction
    • Replies: 19
    • Forum: Supplements, Pharmaceutical Drugs
  10. haidut

    Mitochondrial dysfunction is a major cause of cardiovascular disease (CVD)

    At a first glance, mitochondrial dysfunction (a "functional" problem) has little in common with the build-up of plaque on arterial walls (a "structural" problem). However, as my readers know quite well, structure and function cannot be separated and a functional pathology is perfectly capable...
    • haidut
    • Thread
    • cvd heart disease inflammation metabolism mitochondria plaque ros
    • Replies: 7
    • Forum: Scientific Studies
  11. haidut

    Neuron/brain growth depends on metabolism (OXPHOS)

    As many of my readers know, the mainstream medical dogma is that the number of neurons in the human grain increases until early adulthood, after which it stops completely. Thus, medicine views the adult human brain as having a fixed number of neurons and any damage to them or complete loss of...
    • haidut
    • Thread
    • brain differentiation growth metabolism mitochondria neuron oxphos
    • Replies: 1
    • Forum: Scientific Studies
  12. A

    DHT + T3 + Creatine combo

    + pyrucet Explosive.
    • Arnau
    • Thread
    • androgens atp creatine dht ethyl acetoacetate ethyl pyruvate metabolism pyrucet pyucet t3
    • Replies: 19
    • Forum: Experiments
  13. Mr Joe

    Fraud Case Report : Hydrocortisone + Acetazolamide

    I am trying to dig Dr. Peat mention of Acetazolamide to help retain CO2. I've found a recent article : "We report a novel presentation of deficit in anterior pituitary function with variable immune deficiency (DAVID) syndrome in a healthy young girl presenting in Addisonian crisis with raised...
    • Mr Joe
    • Thread
    • acetazolamide co2 cortisol intracranial intracranial pressure metabolism
    • Replies: 2
    • Forum: CO2, Bag Breathing
  14. EnergeticLeo

    Can anyone help me find this study that Ray references?

    Ray talks about a group of women trying to lose weight who were found to be able to gain weight on even 700 calories a day, where the food was controlled in metabolic wards. He mentions it here, for example: View: https://youtu.be/yylOTFJFxko?t=1203 Does anyone know what study he's referring...
    • EnergeticLeo
    • Thread
    • metabolic rate metabolism obesity thyroid weight gain
    • Replies: 0
    • Forum: Metabolism
  15. haidut

    Harvard Psychiatrist: All Mental Disease is Metabolic/Bioenergetic Disease

    It is always nice to see mainstream medicine plagiarize from Dr. Peat attempt to right its course after decades-long mistakes. While the genetic dogma still rules supreme in medicine's attitude towards most "physical" diseases, the utter failure of the "serotonin hypothesis" and its dear...
    • haidut
    • Thread
    • diet energy mental disease mental health metabolism mitochondria oxphos stress
    • Replies: 32
    • Forum: Scientific Studies
  16. EnergeticLeo

    The one metric to optimise. What is a "good" metabolic rate / gram of tissue?

    In Peat's Optimizing Respiration newsletter, he says: Does anyone have any sources of data on what the population average for metabolic rate adjusted per gram of bodyweight, and adjusted for physical activity? It would be interesting to have a benchmark.
  17. EnergeticLeo

    Thoughts on combining machine learning and bioenergetics?

    I've been thinking about this a lot recently, since I'm a programmer by trade, with an interest in stats and machine learning (ML). I have a sense that there is huge untapped potential in the combination of the metabolic view of health and ML. More health-tech companies I don't think have a...
  18. EnergeticLeo

    Nice video on the electron transport chain!

    View: https://www.youtube.com/watch?v=UyTto4Aegss Really enjoyed this video - there were some holes in my understanding that I wanted to fill up. I'm sure it's not perfect, but I still found it useful.
  19. haidut

    Disrupting mitochondrial function can cause severe anemia

    Most doctors consider anemia mostly an iron-related issue, despite the fact that iron supplementation often fails to correct the condition, even in people with true iron deficiency anemia (e.g. low iron saturation index, low ferritin, high transferin). The role of bioenergetics is rarely...
    • haidut
    • Thread
    • anemia hematopoiesis metabolism mitochondria oxphos rbc thyroid
    • Replies: 1
    • Forum: Scientific Studies
  20. haidut

    Hypothyroidism, deficiency of calcium, vitamin D/B12 may cause hair graying

    Yet another study/article that reports a link between bioenergetics and hair color. Premature graying has been one of the fastest-growing "epidemics" over the last 20 years in developed countries. While a connection with stress has been suggested by numerous studies, mainstream medicine has...
    • haidut
    • Thread
    • calcium graying hair hypothyroidism metabolism thyroid vitamin b12 vitamin d
    • Replies: 13
    • Forum: Scientific Studies
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