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Another study implicating endotoxin (LPS) and its associated receptor (TLR4) in a phenotype of aging considered "normal" by mainstream medicine, though it almost universally progresses into dementia territory with advancing age, to the point where 90%+ of people over 85 have at least moderate...
I’d love to know peoples’ thoughts on how Lion’s mane mushroom & methylene blue compare.
From what I understand, both are useful for improved mental clarity, memory, and they have potential in cases of Alzheimer’s.
I just ordered some methylene blue, and am curious/excited to experiment with...
Just a quick announcement that we have replaced the 5α-DHP in our store with allopregnanolone. The main reason for switching over to allopregnanolone is that we always wanted to provide that steroid right from the start, however we could not find a lab willing to synthesize it. Thus, 5α-DHP...
A new study demonstrating that even short-term (less than a month) exposure to polluted air impaired cognition in humans, and that the mechanism of action was by triggering an inflammatory response. Ergo, anti-inflammatory drugs (NSAID) and especially aspirin, were found to be protective. Since...
As many of my readers know, the WHI studies were highly detrimental to the profits of the estrogen industry. Every since the results of those studies came out, the estrogen industry has been trying to undermine the findings and re-introduce estrogen HRT for women with the claims that estrogen is...
Every time I look at the title for this post I can’t help but think – so, how are wasps different from us humans? I think the answer is – not much, if at all. And this is pretty much what the study below argues, adding yet another piece to an already sizeable mountain of evidence showing that...
The condition known as “chemobrain” is notorious among cancer survivors and many other patients undergoing toxic interventions with chemotherapy and may affect up to 85% of cancer patients. It amounts to severe cognitive dysfunction, memory problems, and even personality changes that result in...
A really great article that not only makes a major argument against the success of AI as implemented in digital computers, but also calls into question the mainstream approach to neuroscience. Even neuroscience currently views the brain as little more than "wetware" - a biological CPU...
This study looks at a concept that Peat has written a lot about and which has been largely ignored by mainstream medicine (in favor of genetic explanations) - epigenetic cell memory. The study only looked at muscle cells but there is no reason to believe the same mechanism is not present in...
There has been some evidence from rodent studies that estrogen and BDNF are antagonistic to each other as animals exposed to estrogen cannot remember very well. BDNF is akin to an anabolic steroid for the brain, and estrogen powerfully impairs its effects, especially in cases of traumatic brain...
I don't fully understand this one myself, it looks interesting though and have seen calcium channel blockers mentioned before on here. The study concludes that this should be considered when designing treatment for dementia and other memoryproblems.
Sex- and dose-dependent effects of post-trial...
Daily supplementation with mushroom (Agaricus bisporus) improves balance and working memory in aged rats. - PubMed - NCBI
Rats on the 2% or 5% mushroom-supplemented diet consumed more food, without gaining weight, than rats in the other diet groups. Rats in the 0.5% and 1% group stayed on a...
Estrogen seems to have very similar effects to serotonin on memory and behavior (as I posted about serotonin earlier this year). This study was human, so the results are even more relevant.
How women navigate depends on their menstrual cycles
"...We found that during the ovulatory phase when...
This mechanism of pregnenolone is one of the proposed methods through which it enhances neurogenesis, memory, mood and even motor function. Low doses pregnenolon improve sleep quality and are even mildly sedating, which may also be due to the activation of the glycine receptor.
Subunit-specific...
I suppose the results of this study are to be expected but I wanted to post it anyways since it was one of the few human studies using methylene blue. The doses used was pretty high (4mg/kg for human) but for some reason the authors claim that this is actually a pretty low dose. Be that as it...
I already posted several studies showing that stress elevates estrogen in males. So much for estrogen being a beneficial female hormone.
Acute stress persistently enhances estrogen levels in the female rat. - PubMed - NCBI
"...Here we tested whether exposure to either tailshock or swim stress...
Evaluation of the effect of pentoxifylline on sleep-deprivation induced memory impairment. - PubMed - NCBI
Abstract
In this study, we examined the ability of Pentoxifylline (PTX) to prevent sleep deprivation induced memory impairment probably through decreasing oxidative stress. Sleep...
Has anyone ever tried the combination of B1 and Thyroid that Peat claims let's you have access to everything you've ever know? I'd be very interested to hear reports!
http://www.ncbi.nlm.nih.gov/pubmed/26274973
Abstract
Our objective was to determine whether dietary vitamin K intake was associated with cognition and behavior among older adults. 192 consecutive participants ≥65 years, recruited in the cross-sectional CLIP (Cognition and LIPophilic vitamins)...