1. F

    Outrageously long flights and sleep

    I'm surprised to find no mention of this, in ploughing through past posts. I'm going to be on a 19-hr flight, followed by another 36 hrs. of waiting and flights to get to my destination. I'd really like to pass out on the 19-hr. flight and willing to ingest substances I would not usually.:) I...
  2. Mauritio

    Rheumatoid Arthritis patients have higher serotonin and cortisol levels

    In this study they looke at some blood markers in patients with RA. As it turns out they have slighlty higher cortisol and way higher serotonin: their serotonin level was 3 times higher! Their melatonin level was a lot lower than that of the control group, which indicates less downstream...
  3. NewACC

    High doses of melatonin can FULLY stop pufa peroxidation This study says that 1.2mM of melatonin can fully stop peroxidation of long-chain pufa, but only particularly block LOX and COX pufa metabolism. High dose of melatonin with such antiserotonin drug like cypro or just with thyroid is very interesting to...
  4. cs3000

    Sunlight brightness not needed for circadian rhythm? (lightbulb brightness can be enough?)

    Probably best to assume sunlight brightness is optimal for circadian rhythm still, (faster effects at that brightness?), but studies have shown light from standard lightbulbs give significant effects on circadian rhythm still, especially if around 500 lux which looks to give full effects in...
  5. Hayley

    Horrible depressive side effects from melatonin

    I just ran out of the melatonin (3 mg) I’ve been taking for 3 months now. I kind of suspected it might be making me sluggish but I kept taking it because I wanted to be knocked out to go to sleep. The past two mornings without taking it the night before I’ve woken up not feeling like a train hit...
  6. C

    Guy claims high dose Melatonin & Niacin is a cure all and also cures Covid/long Covid and vaccine damage

    I wondered what you guys think about this. Dmitry Kat's who is supposedly an epidemiologist/PHD was recently gaining a lot of attention on twitter promoting his protocol of Niacin and Melatonin to cure Covid and vaccine damage. He's since been banned and is now on telegram. He's kicked me out of...
  7. haidut

    Upregulated serotonin synthesis may be a biomarker for breast cancer

    Once again, the available evidence contradicts the popular myth promoted by public health agencies that serotonin is the "happiness hormone". One only needs to talk to a person on serotonergic (SSRI) drugs for a few minutes to realize just how "happy" those people are as a result of their...
  8. Lokzo

    ?A Melatonin Alternative Drug

  9. Drareg

    10 methoxyharamlan

    @haidut mentioned this in the latest Danny Roddy interview. Just starting this thread to get more info on it, I only found 2 studies on it so far. Its an alkaloid obtained by the cyclodehydration of melatonin. Anybody with experience using it?
  10. V

    Melatonin Supplementation

    I was reading on topical melatonin for hair regrowth, which is based on the fact that hair has a melatonin receptor and a few studies that may or may not prove that some regrowth can be achieved thanks to rubbing that around. Now I’ve done a DUTCH test and melatonin was low. Granted it was last...
  11. S.Seneff

    Evaluation Of The Role Of Melatonin In The Metastasis Of Papillary Thyroid Carcinoma

    Article in Chinese; Abstract available in Chinese from the publisher] Fan L1, Xiong YP1, Liu HT1, Min X1, Tang YQ1, Zhang ZY1. Author information 1 Department of Otolaryngology Head and Neck Surgery,First Affiliated Hospital of Nanchang University,Nanchang,330006,China. Abstract in English...
  12. haidut

    Pineal Gland Chemicals Inhibit Androgen Synthesis

    There is great interest in the blogosophere in writing about and supplementing with the pineal hormone melatonin. Ray has written about the dangers of melatonin, but there is enough contradictory research to confuse people. This study shows that another pineal hormone, which ALWAYS rises...
  13. haidut

    Melatonin Elevates Brain Serotonin

    Ray has repeatedly warned against the exogenous supplementation with melatonin and has said that it is almost as dangerous as serotonin (of which melatonin is a metabolite). One of the main benefits of red light is that it sharply decreases melatonin synthesis, sometimes by as much as 90%. I...
  14. P


    Considering Peat considers melatonin a stress hormone, does he recommend waking up every few hours to turn on a light or leaving a light on while you sleep? It seems to make sense to limit melatonin production, but also seems like it would prevent proper sleep. Strangely enough, since I cleaned...
  15. J


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